Reactome | Upf3a [cytosol]

Upf3a [cytosol]

Stable Identifier

R-RNO-927801

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

cytosol

Synonyms

UPF3A, F7F115

Locations in the PathwayBrowser

Expand all

Metabolism of RNA (Rattus norvegicus)

- Nonsense-Mediated Decay (NMD) (Rattus norvegicus)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Rattus norvegicus)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Rattus norvegicus)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Rattus norvegicus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Rattus norvegicus)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Rattus norvegicus)
        
        UPF3 [cytosol] (Rattus norvegicus)
        
        Upf3a [cytosol] (Rattus norvegicus)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Rattus norvegicus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Rattus norvegicus)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Rattus norvegicus)
        
        UPF3 [cytosol] (Rattus norvegicus)
        
        Upf3a [cytosol] (Rattus norvegicus)
    - SMG6 hydrolyzes mRNA with premature termination codon (Rattus norvegicus)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Rattus norvegicus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Rattus norvegicus)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Rattus norvegicus)
        
        UPF3 [cytosol] (Rattus norvegicus)
        
        Upf3a [cytosol] (Rattus norvegicus)
        
        Upf3a [cytosol] (Rattus norvegicus)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Rattus norvegicus)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Rattus norvegicus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Rattus norvegicus)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Rattus norvegicus)
        
        UPF3 [cytosol] (Rattus norvegicus)
        
        Upf3a [cytosol] (Rattus norvegicus)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Rattus norvegicus)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Rattus norvegicus)
        
        UPF3 [cytosol] (Rattus norvegicus)
        
        Upf3a [cytosol] (Rattus norvegicus)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Rattus norvegicus)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Rattus norvegicus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Rattus norvegicus)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Rattus norvegicus)
        
        UPF3 [cytosol] (Rattus norvegicus)
        
        Upf3a [cytosol] (Rattus norvegicus)
        
        Upf3a [cytosol] (Rattus norvegicus)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Rattus norvegicus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Rattus norvegicus)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Rattus norvegicus)
        
        UPF3 [cytosol] (Rattus norvegicus)
        
        Upf3a [cytosol] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:F7F115

Gene Names

Upf3a

Reference Genes

ENSEMBL:ENSRNOG00000017397

ENSEMBL:ENSRNOG00000017397.8 Upf3a

Other Identifiers

10792702

1378275_at

17712874

361176

5645546

5784095

5955324

5975359

6042084

6068695

6084000

6120617

6181484

6378672

6439457

6544556

6569236

A_44_P281328

GE1201498

GO:0000184

GO:0001701

GO:0003676

GO:0003677

GO:0003723

GO:0003729

GO:0005634

GO:0005654

GO:0005829

GO:0007283

GO:0016071

GO:0022414

GO:0035145

GO:0042162

GO:0043005

GO:0043226

GO:0043231

GO:0045727

GO:0048856

GO:1905746

GO:2000623

ILMN_1376244

PH_rn_0007221

Participates

as a component of

Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Rattus norvegicus)

as a member of

UPF3 [cytosol] (Rattus norvegicus)

Inferred From

UPF3AS-2 [cytosol] (Homo sapiens)

UPF3A [cytosol] (Homo sapiens)

Cross References

Ensembl

ENSRNOP00000060194, ENSRNOG00000017397, ENSRNOT00000066521

RGD

1308778