Reactome | Dlg2 [plasma membrane]

Dlg2 [plasma membrane]

Stable Identifier

R-RNO-9610662

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

plasma membrane

Synonyms

DLG2, Q63622

Locations in the PathwayBrowser

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Neuronal System (Rattus norvegicus)

- Transmission across Chemical Synapses (Rattus norvegicus)
  - Neurotransmitter receptors and postsynaptic signal transmission (Rattus norvegicus)
    - Activation of NMDA receptors and postsynaptic events (Rattus norvegicus)
      - Unblocking of NMDA receptors, glutamate binding and activation (Rattus norvegicus)
        
        Ca2+ influx into the post-synaptic cell (Rattus norvegicus)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2 NMDA receptors [plasma membrane] (Rattus norvegicus)
        
        GRIN1:GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Rattus norvegicus)
        
        GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane] (Rattus norvegicus)
        
        GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL [plasma membrane] (Rattus norvegicus)
        
        GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Rattus norvegicus)
        
        DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Rattus norvegicus)
        
        Dlg2 [plasma membrane] (Rattus norvegicus)
        
        Membrane depolarization upon activation of Ca impermeable AMPA receptors (Rattus norvegicus)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors:p-T286-CaMKII dodecamer:CALM1:4xCa2+ [plasma membrane] (Rattus norvegicus)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors [plasma membrane] (Rattus norvegicus)
        
        GRIN1:GRIN2B NMDA receptors:PSD proteins [plasma membrane] (Rattus norvegicus)
        
        GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane] (Rattus norvegicus)
        
        GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL [plasma membrane] (Rattus norvegicus)
        
        GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Rattus norvegicus)
        
        DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Rattus norvegicus)
        
        Dlg2 [plasma membrane] (Rattus norvegicus)

Signal Transduction (Rattus norvegicus)

- MAPK family signaling cascades (Rattus norvegicus)
  - MAPK1/MAPK3 signaling (Rattus norvegicus)
    - RAF/MAP kinase cascade (Rattus norvegicus)
      - RAS GEFs promote RAS nucleotide exchange (Rattus norvegicus)
        
        RAS GEFs [plasma membrane] (Rattus norvegicus)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptor:RASGRF1 oligomer:CALM1:4xCa2+ [plasma membrane] (Rattus norvegicus)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors [plasma membrane] (Rattus norvegicus)
        
        GRIN1:GRIN2B NMDA receptors:PSD proteins [plasma membrane] (Rattus norvegicus)
        
        GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane] (Rattus norvegicus)
        
        GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL [plasma membrane] (Rattus norvegicus)
        
        GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Rattus norvegicus)
        
        DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Rattus norvegicus)
        
        Dlg2 [plasma membrane] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:Q63622

Gene Names

Dlg2

Reference Genes

BioGPS Gene:64053 Dlg2

ENSEMBL:ENSRNOG00000022635

ENSEMBL:ENSRNOG00000022635.8 Dlg2

KEGG Gene (Rattus norvegicus):64053 Dlg2

Monarch:64053 Dlg2

NCBI Gene:64053 Dlg2

UCSC:Q63622 Dlg2

Reference Transcript

RefSeq:NM_022282.1 Dlg2

Other Identifiers

10708618

1398276_at

17618236

5621919

5644700

5663264

5681407

5850260

5853811

5880249

6010638

6072982

6107829

6174698

6214699

6251614

6252468

6264636

6290319

6302520

6326220

6352103

64053

6425806

6474602

6534324

6549252

6555344

6602857

6688706

6737726

A_44_P193904

A_64_P071446

GO:0005515

GO:0007268

GO:0019900

GO:0023052

GO:0031594

GO:0043005

U49049_at

U50717_s_at

Participates

as a member of

DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Rattus norvegicus)

Other forms of this molecule

Dlg2 [cytosol]

Inferred From

DLG2 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_071618.1

Ensembl

ENSRNOG00000022635, ENSRNOP00000092409, ENSRNOT00000108774, ENSRNOP00000097641, ENSRNOT00000110277

PRO

Q63622

RGD

619895

PDB

4H11

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P97836 Dlgap1	2	Gkap1 [plasma membrane] (R-RNO-6794237) Dlgap1 [plasma membrane] (R-RNO-6794239)	0.547	2

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