Reactome | CAMK2B [cytosol]

CAMK2B [cytosol]

Stable Identifier

R-RNO-9611360

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

cytosol

Synonyms

P08413

Locations in the PathwayBrowser

Expand all

Neuronal System (Rattus norvegicus)

- Transmission across Chemical Synapses (Rattus norvegicus)
  - Neurotransmitter receptors and postsynaptic signal transmission (Rattus norvegicus)
    - Activation of NMDA receptors and postsynaptic events (Rattus norvegicus)
      - Unblocking of NMDA receptors, glutamate binding and activation (Rattus norvegicus)
        
        Ca2+ influx into the post-synaptic cell (Rattus norvegicus)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2 NMDA receptors [plasma membrane] (Rattus norvegicus)
        
        GRIN1:GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Rattus norvegicus)
        
        CaMKII dodecamer [cytosol] (Rattus norvegicus)
        
        CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Rattus norvegicus)
        
        CAMK2B [cytosol] (Rattus norvegicus)
        
        Membrane depolarization upon activation of Ca impermeable AMPA receptors (Rattus norvegicus)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors:p-T286-CaMKII dodecamer:CALM1:4xCa2+ [plasma membrane] (Rattus norvegicus)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors [plasma membrane] (Rattus norvegicus)
        
        GRIN1:GRIN2B NMDA receptors:PSD proteins [plasma membrane] (Rattus norvegicus)
        
        CaMKII dodecamer [cytosol] (Rattus norvegicus)
        
        CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Rattus norvegicus)
        
        CAMK2B [cytosol] (Rattus norvegicus)

Signal Transduction (Rattus norvegicus)

- MAPK family signaling cascades (Rattus norvegicus)
  - MAPK1/MAPK3 signaling (Rattus norvegicus)
    - RAF/MAP kinase cascade (Rattus norvegicus)
      - RAS GEFs promote RAS nucleotide exchange (Rattus norvegicus)
        
        RAS GEFs [plasma membrane] (Rattus norvegicus)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptor:RASGRF1 oligomer:CALM1:4xCa2+ [plasma membrane] (Rattus norvegicus)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors [plasma membrane] (Rattus norvegicus)
        
        GRIN1:GRIN2B NMDA receptors:PSD proteins [plasma membrane] (Rattus norvegicus)
        
        CaMKII dodecamer [cytosol] (Rattus norvegicus)
        
        CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Rattus norvegicus)
        
        CAMK2B [cytosol] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:P08413 Camk2b

Gene Names

Camk2b

Chain

chain:1-542

Reference Genes

BioGPS Gene:24245 Camk2b

KEGG Gene (Rattus norvegicus):24245 Camk2b

Monarch:24245 Camk2b

NCBI Gene:24245 Camk2b

UCSC:P08413 Camk2b

Reference Transcript

Participates

as a member of

CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Rattus norvegicus)

Other forms of this molecule

phospho-p-T287-CAMK2B [plasma membrane]

phospho-p-T287-CAMK2B [nucleoplasm]

phospho-p-T287-CAMK2B [endocytic vesicle membrane]

p-T287-Camk2b [cytosol]

Camk2b [cytosol]

phospho-p-T287-CAMK2B [cytosol]

Inferred From

CAMK2B [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001035815.1, NP_068507.2

IntEnz

2.7.11.17

PRO

P08413

RGD

2262

PDB

6HCS

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q63053 Arc	1	Arc [cytosol] (R-RNO-9619854)	0.634	6
UniProt:P60709 ACTB	5	Unfolded ACTB [cytosol] (R-HSA-390462) ACTB(1-375) [nucleoplasm] (R-HSA-3321990) ACTB(1-375) [cytosol] (R-HSA-201861) ACTB(1-375) [lysosomal membrane] (R-HSA-196160) ACTB(1-375) [plasma membrane] (R-HSA-196016)	0.615	4