Erbb4 binds Dlg4

Stable Identifier
R-RNO-9612569
Type
Reaction [binding]
Species
Rattus norvegicus
Compartment
Synonyms
Erbb4 binds Psd95
General
SVG |   | PPTX  | SBGN
Erbb4 binds Dlg4

In rat brain neurons, Erbb4 binds to the postsynaptic density (PSD) protein Dlg4 (PSD-95). One molecule of Dlg4 can bind two molecules of Erbb4, which may facilitate Erbb4 dimerization upon ligand binding (Huang et al. 2000, Garcia et al. 2000, Mitchell et al. 2013).

Literature References
PubMed ID Title Journal Year
24218551 ErbB4 reduces synaptic GABAA currents independent of its receptor tyrosine kinase activity

Mitchell, RM, Janssen, MJ, Karavanova, I, Vullhorst, D, Furth, K, Makusky, A, Markey, SP, Buonanno, A

Proc. Natl. Acad. Sci. U.S.A. 2013
10725395 The neuregulin receptor ErbB-4 interacts with PDZ-containing proteins at neuronal synapses

Garcia, RA, Vasudevan, K, Buonanno, A

Proc. Natl. Acad. Sci. U.S.A. 2000
10839362 Regulation of neuregulin signaling by PSD-95 interacting with ErbB4 at CNS synapses

Huang, YZ, Won, S, Ali, DW, Wang, Q, Tanowitz, M, Du, QS, Pelkey, KA, Yang, DJ, Xiong, WC, Salter, MW, Mei, L

Neuron 2000
Participants
Orthologous Events
Authored
Created
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