Erbb4 binds Dlg4

Stable Identifier
R-RNO-9612569
Type
Reaction [binding]
Species
Rattus norvegicus
Compartment
plasma membrane
Synonyms
Erbb4 binds Psd95
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Erbb4 binds Dlg4
In rat brain neurons, Erbb4 binds to the postsynaptic density (PSD) protein Dlg4 (PSD-95). One molecule of Dlg4 can bind two molecules of Erbb4, which may facilitate Erbb4 dimerization upon ligand binding (Huang et al. 2000, Garcia et al. 2000, Mitchell et al. 2013).
Literature References
PubMed ID Title Journal Year
10725395 The neuregulin receptor ErbB-4 interacts with PDZ-containing proteins at neuronal synapses

Buonanno, A, Vasudevan, K, Garcia, RA

Proc. Natl. Acad. Sci. U.S.A. 2000
24218551 ErbB4 reduces synaptic GABAA currents independent of its receptor tyrosine kinase activity

Buonanno, A, Makusky, A, Janssen, MJ, Karavanova, I, Furth, K, Markey, SP, Vullhorst, D, Mitchell, RM

Proc. Natl. Acad. Sci. U.S.A. 2013
10839362 Regulation of neuregulin signaling by PSD-95 interacting with ErbB4 at CNS synapses

Pelkey, KA, Wang, Q, Du, QS, Huang, YZ, Tanowitz, M, Ali, DW, Won, S, Yang, DJ, Mei, L, Xiong, WC, Salter, MW

Neuron 2000
Participants
Input
Output
Orthologous Events
ERBB4 binds DLG4 (Homo sapiens)
Authored
Stern, DF  (2019-02-21)
Orlic-Milacic, M  (2018-06-28)
Created
Orlic-Milacic, M  (2018-06-28)
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