Reactome | Dlg4 [plasma membrane]

Dlg4 [plasma membrane]

Stable Identifier

R-RNO-9612601

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

plasma membrane

Synonyms

Psd-95

Locations in the PathwayBrowser

Expand all

Immune System (Rattus norvegicus)

- Cytokine Signaling in Immune system (Rattus norvegicus)
  - FLT3 Signaling (Rattus norvegicus)
    - RAF/MAP kinase cascade (Rattus norvegicus)
      - RAS GEFs promote RAS nucleotide exchange (Rattus norvegicus)
        
        RAS GEFs [plasma membrane] (Rattus norvegicus)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptor:RASGRF1 oligomer:CALM1:4xCa2+ [plasma membrane] (Rattus norvegicus)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors [plasma membrane] (Rattus norvegicus)
        
        GRIN1:GRIN2B NMDA receptors:PSD proteins [plasma membrane] (Rattus norvegicus)
        
        GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane] (Rattus norvegicus)
        
        GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL [plasma membrane] (Rattus norvegicus)
        
        GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Rattus norvegicus)
        
        DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Rattus norvegicus)
        
        Dlg4 [plasma membrane] (Rattus norvegicus)
        
        Dlg4 [plasma membrane] (Rattus norvegicus)

Signal Transduction (Rattus norvegicus)

- MAPK family signaling cascades (Rattus norvegicus)
  - MAPK1/MAPK3 signaling (Rattus norvegicus)
    - RAF/MAP kinase cascade (Rattus norvegicus)
      - RAS GEFs promote RAS nucleotide exchange (Rattus norvegicus)
        
        RAS GEFs [plasma membrane] (Rattus norvegicus)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptor:RASGRF1 oligomer:CALM1:4xCa2+ [plasma membrane] (Rattus norvegicus)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors [plasma membrane] (Rattus norvegicus)
        
        GRIN1:GRIN2B NMDA receptors:PSD proteins [plasma membrane] (Rattus norvegicus)
        
        GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane] (Rattus norvegicus)
        
        GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL [plasma membrane] (Rattus norvegicus)
        
        GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Rattus norvegicus)
        
        DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Rattus norvegicus)
        
        Dlg4 [plasma membrane] (Rattus norvegicus)
        
        Dlg4 [plasma membrane] (Rattus norvegicus)
- Signaling by Rho GTPases (Rattus norvegicus)
  - RHO GTPase Effectors (Rattus norvegicus)
    - RHO GTPases activate CIT (Rattus norvegicus)
      - CIT-3 binds DLG4 (Rattus norvegicus)
        
        Dlg4 [plasma membrane] (Rattus norvegicus)
        
        RHOA,RHOB,RHOC,RAC1:GTP:CIT-3:DLG4 [plasma membrane] (Rattus norvegicus)
        
        Dlg4 [plasma membrane] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:P31016 Dlg4

Gene Names

Dlg4, Dlgh4, Psd95

Chain

chain:1-724

Reference Genes

BioGPS Gene:29495 Dlg4

ENSEMBL:ENSRNOG00000018526 Dlg4

KEGG Gene (Rattus norvegicus):29495 Dlg4

Monarch:29495 Dlg4

NCBI Gene:29495 Dlg4

UCSC:P31016 Dlg4

Reference Transcript

RefSeq:NM_019621.1 Dlg4

Other Identifiers

00230+2.7.4.8

10735135

1371183_a_at

1387210_at

17647672

1BE9

1BFE

1IU0

1IU2

1JXM

1JXO

1KJW

1QLC

1RGR

1TP3

1TP5

1TQ3

29495

2KA9

2MHO

2XKX

3GSL

3WP0

3WP1

5654463

5657760

5705078

5748730

5753691

5788932

5869203

5B64

5D13

5GNV

5HDY

5HEB

5HED

5HET

5HEY

5HF1

5HF4

5HFB

5HFC

5HFD

5HFE

5HFF

5MZ7

5W72

5YPO

5YPR

6026595

6085126

6175568

6176681

6199575

6210332

6302931

6363930

6378769

6500607

6521647

6594794

6635340

6694969

68424

A0A0G2K7F5

A_44_P238312

AAA41971

AAB38270

CAA47103

Dlg4

Dlg4-201

ENSRNOG00000018526

ENSRNOP00000059045

ENSRNOT00000068493

EntrezGene:29495

EntrezGene:Dlg4

GE1108863

GE22051

GO:0000902

GO:0002091

GO:0003674

GO:0005102

GO:0005109

GO:0005198

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005737

GO:0005783

GO:0005829

GO:0005886

GO:0005911

GO:0006464

GO:0006810

GO:0007155

GO:0007165

GO:0007204

GO:0007267

GO:0007268

GO:0008021

GO:0008022

GO:0008076

GO:0008092

GO:0008150

GO:0008328

GO:0014069

GO:0016020

GO:0016188

GO:0016192

GO:0019865

GO:0019894

GO:0019899

GO:0019901

GO:0019903

GO:0021700

GO:0022607

GO:0030054

GO:0030154

GO:0030165

GO:0030424

GO:0030425

GO:0031234

GO:0031410

GO:0031594

GO:0031697

GO:0031698

GO:0031748

GO:0031812

GO:0032281

GO:0032839

GO:0032991

GO:0033130

GO:0035176

GO:0035254

GO:0035255

GO:0035418

GO:0035641

GO:0042592

GO:0042995

GO:0043005

GO:0043113

GO:0043197

GO:0043226

GO:0044224

GO:0044306

GO:0044309

GO:0044877

GO:0045161

GO:0045184

GO:0045202

GO:0045211

GO:0048169

GO:0048856

GO:0050806

GO:0050877

GO:0050885

GO:0055085

GO:0060076

GO:0060997

GO:0061024

GO:0061098

GO:0065003

GO:0071625

GO:0097061

GO:0097109

GO:0097110

GO:0097113

GO:0097120

GO:0098609

GO:0098839

GO:0098919

GO:0098970

GO:0098978

GO:0099031

GO:0099562

GO:0150012

GO:2000310

GO:2000463

GO:2000821

ILMN_1650748

IPR001452

IPR001478

IPR008144

IPR008145

IPR016313

IPR019583

IPR019590

IPR020590

IPR027417

IPR036028

IPR036034

M96853

M96853_at

NM_019621

NP_062567

PF00018

PF00595

PF00625

PF10600

PF10608

PH_rn_0011964

SM00072

SM00228

SM00326

SM01277

U77090

UPI0000129480

X66474

XM_006246680

XM_006246681

XM_006246682

XM_006246683

XM_006246684

XM_006246685

XM_006246686

XM_006246687

XM_006246688

XM_006246689

XM_006246691

XM_008767809

XM_008767810

XP_006246746

XP_006246749

XP_008766031

XR_357666

Participant Of

hasComponent

input

hasMember

Other forms of this molecule

DLG4 [endocytic vesicle membrane]

Dlg4 [cytosol]

Inferred From

DLG4 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_062567.1

PRO

P31016

PDB

1TP5, 1RGR, 5D13, 1BE9, 1QLC, 3WP0, 5HED, 5HEB, 5YPR, 5YPO, 2KA9, 1BFE, 5HFD, 2XKX, 5HFE, 3GSL, 5HFB, 5HFC, 1JXM, 1IU0, 5HFF, 1JXO, 5HDY, 1IU2, 1TP3, 2MHO, 5W72, 5HEY, 5HF4, 5GNV, 3WP1, 1KJW, 5HF1, 5B64, 5HET, 1TQ3, 5MZ7

Interactors (41)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q00960 Grin2b	7	Grin2b [plasma membrane] (R-RNO-6794241) GRIN2B [plasma membrane] (R-RNO-419558) p-Y-Grin2b [plasma membrane] (R-RNO-9628248) GRIN2B [endoplasmic reticulum membrane] (R-RNO-9609765) Grin2b [endoplasmic reticulum membrane] (R-RNO-9609846) p-Y1472-Grin2b [plasma membrane] (R-RNO-9032617) phospho-p-Y1252,Y1336,Y1474-GRIN2B [plasma membrane] (R-RNO-3928477)	0.915	11
UniProt:P97836 Dlgap1	2	DLGAP1 [plasma membrane] (R-RNO-6794239) Gkap1 [plasma membrane] (R-RNO-6794237)	0.843	9
UniProt:Q00959 Grin2a	3	p-Y-Grin2a [plasma membrane] (R-RNO-9628245) Grin2a [endoplasmic reticulum membrane] (R-RNO-9609845) Grin2a [plasma membrane] (R-RNO-6794271)	0.791	8
UniProt:P34926 MAP1A			0.784	16
UniProt:P35439 Grin1	2	Grin1 [plasma membrane] (R-RNO-9610826) Grin1 [endoplasmic reticulum membrane] (R-RNO-9609841)	0.708	4
UniProt:P22459 KCNA4	1	KCNA4 [plasma membrane] (R-HSA-977474)	0.676	3
UniProt:P05480 Src	12	phospho-p-Y419-SRC [cytosol] (R-MMU-377592) SRC-2 [cytosol] (R-MMU-191648) phospho-MyrG-p-Y419-SRC [plasma membrane] (R-MMU-1810408) SRC-1 [plasma membrane] (R-MMU-65043) phospho-MyrG,p-Y530-SRC [plasma membrane] (R-MMU-377598) Src [cytosol] (R-MMU-418782) phospho-p-Y419-SRC-1 [plasma membrane] (R-MMU-112331) MyrG-SRC [plasma membrane] (R-MMU-8876922) MyrG-p-Y424-Src [plasma membrane] (R-MMU-9011258) Activated Src [nucleoplasm] (R-MMU-8937700) phospho-p-Y416-SRC [cytosol] (R-MMU-8964276) SRC [cytosol] (R-MMU-9628701)	0.645	9
UniProt:P08588 ADRB1	1	ADRB1 [plasma membrane] (R-HSA-390653)	0.623	2
UniProt:O54857	14	PTEN [nucleoplasm] (R-RNO-5690148) K48polyUb-PTEN [cytosol] (R-RNO-8874327) PolyUb-PTEN [nucleoplasm] (R-RNO-6782515) phospho-p-Y336-PTEN [cytosol] (R-RNO-8847980) phospho-PolyUb-K324,K344,K349-RibC-E40,E150,D326-PTEN [cytosol] (R-RNO-8948841) phospho-RibC-E40,E150,D326-PTEN [cytosol] (R-RNO-8948798) phospho-p-3S,2T-PTEN [cytosol] (R-RNO-8850936) K27polyUb-PTEN [cytosol] (R-RNO-8851009) PolyUb-PTEN [cytosol] (R-RNO-6807280) K48polyUb-K289-PTEN [cytosol] (R-RNO-8948777) MonoUb-K13,K289-PTEN [cytosol] (R-RNO-6807247) MonoUb-K13,K289-PTEN [nucleoplasm] (R-RNO-6807264) PTEN [nucleoplasm] (R-RNO-6807273) PTEN [cytosol] (R-RNO-199420)	0.612	5
UniProt:Q9WVI4 Gucy1a2	1	Guanylate cyclase soluble subunit alpha-2 [cytosol] (R-RNO-427260)	0.602	7
UniProt:P28572-2 SLC6A9			0.602	4
UniProt:Q810C5 Q810C5			0.599	5
UniProt:Q9Z252 Lin7b	1	Lin7b [plasma membrane] (R-RNO-6794272)	0.599	6
UniProt:Q12959-2 DLG1			0.591	9
UniProt:Q91ZD4 Vangl2	2	Vangl2 [plasma membrane] (R-MMU-4551496) pS5,S82,S84-Vangl2 [plasma membrane] (R-MMU-4551502)	0.591	6
UniProt:O08560	1	DGKZ [plasma membrane] (R-RNO-426060)	0.59	6
UniProt:Q71RJ2	2	CACNG2 [endocytic vesicle membrane] (R-RNO-416846) CACNG2 [plasma membrane] (R-RNO-210375)	0.589	2
UniProt:Q9WV48 Shank1	2	SHANK1 [cytosol] (R-RNO-6794274) Shank1 [cytosol] (R-RNO-6794229)	0.564	3
UniProt:Q12879 GRIN2A	3	p-Y-GRIN2A [plasma membrane] (R-HSA-9612190) GRIN2A [plasma membrane] (R-HSA-419556) GRIN2A [endoplasmic reticulum membrane] (R-HSA-9609760)	0.558	2
UniProt:Q14957 GRIN2C	3	p-Y-GRIN2C [plasma membrane] (R-HSA-9612189) GRIN2C [endoplasmic reticulum membrane] (R-HSA-9609761) GRIN2C [plasma membrane] (R-HSA-419560)	0.558	2
UniProt:Q9P021 CRIPT			0.558	2
IntAct:EBI-16035555 CRIPT-1			0.558	2
UniProt:Q13224 GRIN2B	6	GRIN2B [plasma membrane] (R-HSA-419558) p-Y1252,Y1336,Y1474-GRIN2B [plasma membrane] (R-HSA-3928477) p-Y-GRIN2B [plasma membrane] (R-HSA-9612185) GRIN2B [endoplasmic reticulum membrane] (R-HSA-9609765) GRIN2B [transport vesicle membrane] (R-HSA-9610568) p-Y1474-GRIN2B [plasma membrane] (R-HSA-9032602)	0.558	2
UniProt:P30937	1	SSTR4 [plasma membrane] (R-RNO-374745)	0.556	3
UniProt:P70587 Lrrc7	4	LRRC7 [specific granule lumen] (R-RNO-6799616) LRRC7 [extracellular region] (R-RNO-6799681) Lrrc7 [cytosol] (R-RNO-9611392) LRRC7 [cytosol] (R-RNO-9611351)	0.556	5
UniProt:Q9Z1T4	1	CNKSR2 [cytosol] (R-RNO-5672632)	0.556	4
UniProt:Q6IN36	1	WIPF1 [cytosol] (R-RNO-201874)	0.556	5
UniProt:Q00961 Grin2c	5	GRIN2C [endoplasmic reticulum membrane] (R-RNO-9609761) Grin2c [endoplasmic reticulum membrane] (R-RNO-9610096) p-Y-Grin2c [plasma membrane] (R-RNO-9628252) Grin2c [plasma membrane] (R-RNO-9614232) GRIN2C [plasma membrane] (R-RNO-419560)	0.553	2
UniProt:Q80Z96 VANG1			0.544	4
UniProt:P70478	6	APC(778-2843) [cytosol] (R-RNO-2976013) APC(1-777) [cytosol] (R-RNO-2976014) APC [cytosol] (R-RNO-2976015) phospho-p-ub-APC [cytosol] (R-RNO-3009421) K63polyUb-APC [cytosol] (R-RNO-5246690) APC [nucleoplasm] (R-RNO-3361755)	0.544	2
UniProt:Q62765-1 NLGN1			0.527	2
UniProt:P97837	1	DLGAP2 [plasma membrane] (R-RNO-6794266)	0.527	2
UniProt:Q8R4T5 GRASP			0.524	3
UniProt:P28572	1	SLC6A9 [plasma membrane] (R-RNO-444127)	0.524	2
UniProt:P20595 Gucy1b1	1	Guanylate cyclase soluble subunit beta-1 [cytosol] (R-RNO-427265)	0.524	2
UniProt:P10608	5	ADRB2 [endosome membrane] (R-RNO-6783036) phospho-pS-ADRB2 [clathrin-coated endocytic vesicle membrane] (R-RNO-8869143) PolyUb-ADRB2 [endosome membrane] (R-RNO-6783066) phospho-pS-ADRB2 [plasma membrane] (R-RNO-8852158) ADRB2 [plasma membrane] (R-RNO-390647)	0.499	2
UniProt:Q460M5	1	SALM1 [plasma membrane] (R-RNO-197665)	0.463	3
UniProt:Q9JJ40 NHRF3			0.463	2
UniProt:Q9EQL9 Sharpin	1	Sharpin [cytosol] (R-RNO-6794270)	0.463	2
UniProt:Q8VHW5	2	CACNG8 [endocytic vesicle membrane] (R-RNO-416848) CACNG8 [plasma membrane] (R-RNO-210486)	0.463	2
UniProt:P19490 Gria1	7	GRIA1 [endoplasmic reticulum membrane] (R-RNO-5689460) GRIA1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-RNO-5689811) GRIA1 [ER to Golgi transport vesicle membrane] (R-RNO-5689810) GRIA1 [endocytic vesicle membrane] (R-RNO-3004479) p-S849-Gria1 [plasma membrane] (R-RNO-9620442) Gria1 [plasma membrane] (R-RNO-9620440) GRIA1 [plasma membrane] (R-RNO-3004495)	0.462	3