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Dlg4 [plasma membrane]
Stable Identifier
R-RNO-9612601
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
plasma membrane
Synonyms
Psd-95
Locations in the PathwayBrowser
Expand all
Developmental Biology (Rattus norvegicus)
LGI-ADAM interactions (Rattus norvegicus)
LGI1 binds ADAM22 and ADAM23 (Rattus norvegicus)
ADAM22:LGI1 dimer:ADAM23 [plasma membrane] (Rattus norvegicus)
ADAM22:PSD-95:stargazin [plasma membrane] (Rattus norvegicus)
Dlg4 [plasma membrane] (Rattus norvegicus)
ADAM22:PSD-95:stargazin [plasma membrane] (Rattus norvegicus)
Dlg4 [plasma membrane] (Rattus norvegicus)
Neuronal System (Rattus norvegicus)
Protein-protein interactions at synapses (Rattus norvegicus)
Synaptic adhesion-like molecules (Rattus norvegicus)
PSD-95 binds NMDA receptor (Rattus norvegicus)
Dlg4 [plasma membrane] (Rattus norvegicus)
NMDAR:PSD-95 [plasma membrane] (Rattus norvegicus)
Dlg4 [plasma membrane] (Rattus norvegicus)
SALM1 binds NMDA receptor (Rattus norvegicus)
NMDAR:PSD-95 [plasma membrane] (Rattus norvegicus)
Dlg4 [plasma membrane] (Rattus norvegicus)
SALM1:NMDAR:PSD-95 [plasma membrane] (Rattus norvegicus)
NMDAR:PSD-95 [plasma membrane] (Rattus norvegicus)
Dlg4 [plasma membrane] (Rattus norvegicus)
SALMs 1-3 bind to PSD-95 family members (Rattus norvegicus)
PSD-95 family [plasma membrane] (Rattus norvegicus)
Dlg4 [plasma membrane] (Rattus norvegicus)
SALMs 1-3:PSD-95 family [plasma membrane] (Rattus norvegicus)
PSD-95 family [plasma membrane] (Rattus norvegicus)
Dlg4 [plasma membrane] (Rattus norvegicus)
Transmission across Chemical Synapses (Rattus norvegicus)
Neurotransmitter receptors and postsynaptic signal transmission (Rattus norvegicus)
Activation of NMDA receptors and postsynaptic events (Rattus norvegicus)
Unblocking of NMDA receptors, glutamate binding and activation (Rattus norvegicus)
Ca2+ influx into the post-synaptic cell (Rattus norvegicus)
Gly,D-Ser:L-Glu:GRIN1:GRIN2 NMDA receptors [plasma membrane] (Rattus norvegicus)
GRIN1:GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Rattus norvegicus)
GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane] (Rattus norvegicus)
GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL [plasma membrane] (Rattus norvegicus)
GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Rattus norvegicus)
DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Rattus norvegicus)
Dlg4 [plasma membrane] (Rattus norvegicus)
Dlg4 [plasma membrane] (Rattus norvegicus)
Membrane depolarization upon activation of Ca impermeable AMPA receptors (Rattus norvegicus)
Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors:p-T286-CaMKII dodecamer:CALM1:4xCa2+ [plasma membrane] (Rattus norvegicus)
Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors [plasma membrane] (Rattus norvegicus)
GRIN1:GRIN2B NMDA receptors:PSD proteins [plasma membrane] (Rattus norvegicus)
GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane] (Rattus norvegicus)
GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL [plasma membrane] (Rattus norvegicus)
GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Rattus norvegicus)
DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Rattus norvegicus)
Dlg4 [plasma membrane] (Rattus norvegicus)
Dlg4 [plasma membrane] (Rattus norvegicus)
Activation of kainate receptors upon glutamate binding (Rattus norvegicus)
Ionotropic activity of kainate receptors (Rattus norvegicus)
Activation of Ca-permeable Kainate Receptor (Rattus norvegicus)
Activation of Ca-permeable Kainate receptors (Rattus norvegicus)
Kainate receptor-glutamate complex [plasma membrane] (Rattus norvegicus)
Kainate Receptors [plasma membrane] (Rattus norvegicus)
GRIK 2 homomer [plasma membrane] (Rattus norvegicus)
GRIK2 interacting proteins [plasma membrane] (Rattus norvegicus)
Dlg4 [plasma membrane] (Rattus norvegicus)
GRIK4 heteromer with GRIK1/2/3 [plasma membrane] (Rattus norvegicus)
GRIK4 interacting proteins [plasma membrane] (Rattus norvegicus)
Dlg4 [plasma membrane] (Rattus norvegicus)
kainate receptor binds glutamate (Rattus norvegicus)
Kainate Receptors [plasma membrane] (Rattus norvegicus)
GRIK 2 homomer [plasma membrane] (Rattus norvegicus)
GRIK2 interacting proteins [plasma membrane] (Rattus norvegicus)
Dlg4 [plasma membrane] (Rattus norvegicus)
GRIK4 heteromer with GRIK1/2/3 [plasma membrane] (Rattus norvegicus)
GRIK4 interacting proteins [plasma membrane] (Rattus norvegicus)
Dlg4 [plasma membrane] (Rattus norvegicus)
Kainate receptor-glutamate complex [plasma membrane] (Rattus norvegicus)
Kainate Receptors [plasma membrane] (Rattus norvegicus)
GRIK 2 homomer [plasma membrane] (Rattus norvegicus)
GRIK2 interacting proteins [plasma membrane] (Rattus norvegicus)
Dlg4 [plasma membrane] (Rattus norvegicus)
GRIK4 heteromer with GRIK1/2/3 [plasma membrane] (Rattus norvegicus)
GRIK4 interacting proteins [plasma membrane] (Rattus norvegicus)
Dlg4 [plasma membrane] (Rattus norvegicus)
Glutamate binding, activation of AMPA receptors and synaptic plasticity (Rattus norvegicus)
Trafficking of AMPA receptors (Rattus norvegicus)
Trafficking of GluR1-containing AMPA receptors (Rattus norvegicus)
TARP-PSD95-Mdm2 [plasma membrane] (Rattus norvegicus)
Dlg4 [plasma membrane] (Rattus norvegicus)
Signal Transduction (Rattus norvegicus)
MAPK family signaling cascades (Rattus norvegicus)
MAPK1/MAPK3 signaling (Rattus norvegicus)
RAF/MAP kinase cascade (Rattus norvegicus)
RAS GEFs promote RAS nucleotide exchange (Rattus norvegicus)
RAS GEFs [plasma membrane] (Rattus norvegicus)
Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptor:RASGRF1 oligomer:CALM1:4xCa2+ [plasma membrane] (Rattus norvegicus)
Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors [plasma membrane] (Rattus norvegicus)
GRIN1:GRIN2B NMDA receptors:PSD proteins [plasma membrane] (Rattus norvegicus)
GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane] (Rattus norvegicus)
GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL [plasma membrane] (Rattus norvegicus)
GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Rattus norvegicus)
DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Rattus norvegicus)
Dlg4 [plasma membrane] (Rattus norvegicus)
Dlg4 [plasma membrane] (Rattus norvegicus)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Rattus norvegicus)
Signaling by Rho GTPases (Rattus norvegicus)
RHO GTPase Effectors (Rattus norvegicus)
RHO GTPases activate CIT (Rattus norvegicus)
CIT-3 binds DLG4 (Rattus norvegicus)
Dlg4 [plasma membrane] (Rattus norvegicus)
RHOA,RHOB,RHOC,RAC1:GTP:CIT-3:DLG4 [plasma membrane] (Rattus norvegicus)
Dlg4 [plasma membrane] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:P31016 Dlg4
Gene Names
Dlg4, Dlgh4, Psd95
Chain
chain:1-724
Reference Genes
BioGPS Gene:29495 Dlg4
KEGG Gene (Rattus norvegicus):29495 Dlg4
Monarch:29495 Dlg4
NCBI Gene:29495 Dlg4
UCSC:P31016 Dlg4
Reference Transcript
RefSeq:NM_019621.1 Dlg4
Participates
as a component of
ADAM22:PSD-95:stargazin [plasma membrane] (Rattus norvegicus)
Erbb4:Dlg4 [plasma membrane] (Rattus norvegicus)
NMDAR:PSD-95 [plasma membrane] (Rattus norvegicus)
RHOA,RHOB,RHOC,RAC1:GTP:CIT-3:DLG4 [plasma membrane] (Rattus norvegicus)
GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Rattus norvegicus)
GRIK2 interacting proteins [plasma membrane] (Rattus norvegicus)
GRIK4 interacting proteins [plasma membrane] (Rattus norvegicus)
TARP-PSD95-Mdm2 [plasma membrane] (Rattus norvegicus)
GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Rattus norvegicus)
as an input of
Erbb4 binds Dlg4 (Rattus norvegicus)
PSD-95 binds NMDA receptor (Rattus norvegicus)
CIT-3 binds DLG4 (Rattus norvegicus)
as a member of
PSD-95 family [plasma membrane] (Rattus norvegicus)
DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Rattus norvegicus)
Other forms of this molecule
Dlg4 [cytosol]
Dlg4 [endocytic vesicle membrane]
Inferred From
DLG4 [plasma membrane]
(Homo sapiens)
Cross References
RefSeq
NP_062567.1
PRO
P31016
RGD
68424
PDB
2MHO
,
5HFD
,
5GNV
,
1BFE
,
2XKX
,
1TP5
,
5HFC
,
1KJW
,
1QLC
,
3GSL
,
5HFB
,
5B64
,
7CQF
,
5HED
,
7F7I
,
1RGR
,
5HEB
,
1TP3
,
5YPR
,
5W72
,
5HFF
,
1BE9
,
1JXM
,
1IU2
,
3WP0
,
1TQ3
,
1JXO
,
5YPO
,
3WP1
,
5D13
,
5HFE
,
7F7G
,
5HDY
,
1IU0
,
5HF4
,
5MZ7
,
5HF1
,
5HEY
,
5HET
,
2KA9
Interactors (43)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q00960 Grin2b
7
phospho-p-Y1252,Y1336,Y1474-GRIN2B [plasma membrane]
(R-RNO-3928477)
p-Y1472-Grin2b [plasma membrane]
(R-RNO-9032617)
p-Y-Grin2b [plasma membrane]
(R-RNO-9628248)
Grin2b [endoplasmic reticulum membrane]
(R-RNO-9609846)
GRIN2B [endoplasmic reticulum membrane]
(R-RNO-9609765)
Grin2b [plasma membrane]
(R-RNO-6794241)
GRIN2B [plasma membrane]
(R-RNO-419558)
0.915
11
UniProt:P97836 Dlgap1
2
Gkap1 [plasma membrane]
(R-RNO-6794237)
Dlgap1 [plasma membrane]
(R-RNO-6794239)
0.843
9
UniProt:Q00959 Grin2a
3
p-Y-Grin2a [plasma membrane]
(R-RNO-9628245)
Grin2a [plasma membrane]
(R-RNO-6794271)
Grin2a [endoplasmic reticulum membrane]
(R-RNO-9609845)
0.791
8
UniProt:P34926 MAP1A
0.784
16
UniProt:P35439 Grin1
2
Grin1 [endoplasmic reticulum membrane]
(R-RNO-9609841)
Grin1 [plasma membrane]
(R-RNO-9610826)
0.708
4
UniProt:P22459 KCNA4
1
KCNA4 [plasma membrane]
(R-HSA-977474)
0.676
3
UniProt:P19490 Gria1
7
GRIA1 [endocytic vesicle membrane]
(R-RNO-3004479)
GRIA1 [plasma membrane]
(R-RNO-3004495)
Gria1 [plasma membrane]
(R-RNO-9620440)
p-S849-Gria1 [plasma membrane]
(R-RNO-9620442)
GRIA1 [endoplasmic reticulum membrane]
(R-RNO-5689460)
GRIA1 [ER to Golgi transport vesicle membrane]
(R-RNO-5689810)
GRIA1 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-RNO-5689811)
0.649
5
UniProt:P05480 Src
13
SRC-2 [cytosol]
(R-MMU-191648)
phospho-MyrG-p-Y419-SRC [plasma membrane]
(R-MMU-1810408)
phospho-MyrG,p-Y530-SRC [plasma membrane]
(R-MMU-377598)
phospho-p-Y419-SRC [cytosol]
(R-MMU-377592)
SRC-1 [plasma membrane]
(R-MMU-65043)
Src [cytosol]
(R-MMU-418782)
phospho-p-Y419-SRC-1 [plasma membrane]
(R-MMU-112331)
MyrG-SRC [plasma membrane]
(R-MMU-8876922)
Activated Src [nucleoplasm]
(R-MMU-8937700)
SRC [cytosol]
(R-MMU-9628701)
phospho-p-Y419-SRC [cytosol]
(R-MMU-8964276)
MyrG-p-Y424-Src [plasma membrane]
(R-MMU-9011258)
p-Y416-Src [cytosol]
(R-MMU-8964306)
0.645
9
UniProt:P08588 ADRB1
1
ADRB1 [plasma membrane]
(R-HSA-390653)
0.623
2
UniProt:O54857 PTEN
0.612
5
UniProt:Q9WVI4 Gucy1a2
2
Guanylate cyclase soluble subunit alpha-2 [cytosol]
(R-RNO-427260)
Gucy1a2 [cytosol]
(R-RNO-391996)
0.602
7
UniProt:P28572-2 SLC6A9
0.602
4
UniProt:Q9Z252 Lin7b
1
Lin7b [plasma membrane]
(R-RNO-6794272)
0.599
6
UniProt:Q12959-2 DLG1
0.591
9
UniProt:Q91ZD4 Vangl2
2
pS5,S82,S84-Vangl2 [plasma membrane]
(R-MMU-4551502)
Vangl2 [plasma membrane]
(R-MMU-4551496)
0.591
6
UniProt:O08560
1
Dgkz [plasma membrane]
(R-RNO-426060)
0.59
6
UniProt:Q71RJ2
2
Cacng2 [plasma membrane]
(R-RNO-210375)
Cacng2 [endocytic vesicle membrane]
(R-RNO-416846)
0.589
2
UniProt:Q9WV48 Shank1
2
Shank1 [cytosol]
(R-RNO-6794229)
Shank1 [cytosol]
(R-RNO-6794274)
0.564
3
UniProt:Q62696 Dlg1
4
Dlg1 [plasma membrane]
(R-RNO-9617427)
Dlg1 [endoplasmic reticulum membrane]
(R-RNO-9610616)
Dlg1 [cytosol]
(R-RNO-416332)
Dlg1 [plasma membrane]
(R-RNO-375977)
0.564
3
UniProt:Q9P021 CRIPT
0.558
2
IntAct:EBI-16035555 CRIPT-1
0.558
2
UniProt:Q14957 GRIN2C
3
GRIN2C [endoplasmic reticulum membrane]
(R-HSA-9609761)
GRIN2C [plasma membrane]
(R-HSA-419560)
p-Y-GRIN2C [plasma membrane]
(R-HSA-9612189)
0.558
2
UniProt:Q12879 GRIN2A
3
p-Y-GRIN2A [plasma membrane]
(R-HSA-9612190)
GRIN2A [plasma membrane]
(R-HSA-419556)
GRIN2A [endoplasmic reticulum membrane]
(R-HSA-9609760)
0.558
2
UniProt:Q13224 GRIN2B
6
p-Y1252,Y1336,Y1474-GRIN2B [plasma membrane]
(R-HSA-3928477)
p-Y1474-GRIN2B [plasma membrane]
(R-HSA-9032602)
p-Y-GRIN2B [plasma membrane]
(R-HSA-9612185)
GRIN2B [transport vesicle membrane]
(R-HSA-9610568)
GRIN2B [endoplasmic reticulum membrane]
(R-HSA-9609765)
GRIN2B [plasma membrane]
(R-HSA-419558)
0.558
2
UniProt:P30937
1
Sstr4 [plasma membrane]
(R-RNO-374745)
0.556
3
UniProt:F1MAB7
1
Dgki [plasma membrane]
(R-RNO-426064)
0.556
4
UniProt:P70587 Lrrc7
4
Lrrc7 [extracellular region]
(R-RNO-6799681)
Lrrc7 [specific granule lumen]
(R-RNO-6799616)
Lrrc7 [cytosol]
(R-RNO-9611392)
Lrrc7 [cytosol]
(R-RNO-9611351)
0.556
5
UniProt:Q9Z1T4
1
Cnksr2 [cytosol]
(R-RNO-5672632)
0.556
4
UniProt:Q6IN36
1
Wipf1 [cytosol]
(R-RNO-201874)
0.556
5
UniProt:Q00961 Grin2c
5
p-Y-Grin2c [plasma membrane]
(R-RNO-9628252)
Grin2c [plasma membrane]
(R-RNO-9614232)
Grin2c [endoplasmic reticulum membrane]
(R-RNO-9610096)
GRIN2C [plasma membrane]
(R-RNO-419560)
GRIN2C [endoplasmic reticulum membrane]
(R-RNO-9609761)
0.553
2
UniProt:Q80Z96
1
Vangl1 [plasma membrane]
(R-MMU-9714275)
0.544
4
UniProt:P70478
6
phospho-Apc [cytosol]
(R-RNO-3009421)
Apc [cytosol]
(R-RNO-5246690)
Apc [nucleoplasm]
(R-RNO-3361755)
Apc [cytosol]
(R-RNO-2976014)
Apc [cytosol]
(R-RNO-2976013)
Apc [cytosol]
(R-RNO-2976015)
0.544
2
UniProt:Q62765-1 NLGN1
0.527
2
UniProt:P97837
1
Dlgap2 [plasma membrane]
(R-RNO-6794266)
0.527
2
UniProt:Q8R4T5 GRASP
0.524
3
UniProt:P28572
1
Slc6a9 [plasma membrane]
(R-RNO-444127)
0.524
2
UniProt:P20595 Gucy1b3
1
Guanylate cyclase soluble subunit beta-1 [cytosol]
(R-RNO-427265)
0.524
2
UniProt:Q5XIE8 ITM2B
0.499
5
UniProt:P10608
5
phospho-Adrb2 [clathrin-coated endocytic vesicle membrane]
(R-RNO-8869143)
Adrb2 [endosome membrane]
(R-RNO-6783036)
Adrb2 [endosome membrane]
(R-RNO-6783066)
phospho-Adrb2 [plasma membrane]
(R-RNO-8852158)
Adrb2 [plasma membrane]
(R-RNO-390647)
0.499
2
UniProt:Q9JJ40 NHRF3
0.463
2
UniProt:Q8VHW5
2
Cacng8 [plasma membrane]
(R-RNO-210486)
Cacng8 [endocytic vesicle membrane]
(R-RNO-416848)
0.463
2
UniProt:Q460M5
1
Lrfn2 [plasma membrane]
(R-RNO-197665)
0.463
3
UniProt:Q9EQL9 Sharpin
1
Sharpin [cytosol]
(R-RNO-6794270)
0.463
2
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