Unblocking of Grin1:Grin2 NMDA receptors

Stable Identifier
R-RNO-9614351
Type
Reaction [dissociation]
Species
Rattus norvegicus
Compartment
General
SVG |   | PPTX  | SBGN
Unblocking of Grin1:Grin2 NMDA receptors

Upon depolarization of rat neurons by the influx of Na+, Mg2+ is removed from the pore of GluN1:GluN2 (Grin1:Grin2) NMDA receptors, resulting in activation of ligand-bound receptors (Clarke et al. 2013).

Literature References
PubMed ID Title Journal Year
23447622 Mechanistic and structural determinants of NMDA receptor voltage-dependent gating and slow Mg2+ unblock

Clarke, RJ, Glasgow, NG, Johnson, JW

J. Neurosci. 2013
Participants
This event is regulated
Orthologous Events
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