Calm1:4xCa2+ binds GluN1:GluN2 (Grin1:Grin2) NMDA receptors and displaces Actn2

Stable Identifier
R-RNO-9617322
Type
Reaction [transition]
Species
Rattus norvegicus
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
General
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PNG
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Calm1:4xCa2+ binds GluN1:GluN2 (Grin1:Grin2) NMDA receptors and displaces Actn2
Based on studies in rat neurons, calmodulin (Calm1), activated by binding to calcium ions (Ca2+), after influx of calcium through the pore of activated GluN1:GluN2 (Grin1:Grin2) NMDA receptors, binds to the GluN1 (Grin1, Nr1) subunit of the NMDA receptors (Ehlers et al. 1995). Binding of calcium-calmodulin complex (Calm1:4xCa2+) competes with binding of alpha-actinin-2 (Actn2) to GluN1, leading to dissociation of NMDA receptors from Actn2 (Wyszynski et al. 1997).
Literature References
PubMed ID Title Journal Year
9009191 Competitive binding of alpha-actinin and calmodulin to the NMDA receptor

Wyszynski, M, Lin, J, Rao, A, Nigh, E, Beggs, AH, Craig, AM, Sheng, M

Nature 1997
8625412 Inactivation of NMDA receptors by direct interaction of calmodulin with the NR1 subunit

Ehlers, MD, Zhang, S, Bernhadt, JP, Huganir, RL

Cell 1996
Participants
Input
Output
Orthologous Events
CALM1:4xCa2+ binds GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors and displaces ACTN2 (Homo sapiens)
Authored
Orlic-Milacic, M  (2018-10-10)
Reviewed
Yi, F  (2018-11-02)
Hansen, KB  (2018-11-02)
Created
Orlic-Milacic, M  (2018-08-22)
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