CaMKII autophosphorylates

Stable Identifier
R-RNO-9618616
Type
Reaction [transition]
Species
Rattus norvegicus
Compartment
cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
CaMKII autophosphorylates
Binding of rat calmodulin, activated by calcium binding, to rat CaMKII leads to catalytic activation of CaMKII and autophosphorylation of CaMKII (Schworer et al. 1986, Meyer et al. 1992).
Literature References
PubMed ID Title Journal Year
3722161 Reversible generation of a Ca2+-independent form of Ca2+(calmodulin)-dependent protein kinase II by an autophosphorylation mechanism

Schworer, CM, Colbran, RJ, Soderling, TR

J. Biol. Chem. 1986
1317063 Calmodulin trapping by calcium-calmodulin-dependent protein kinase

Meyer, T, Hanson, PI, Stryer, L, Schulman, H

Science 1992
Participants
Input
Output
Catalyst Activity

protein serine/threonine kinase activity of CaMKII dodecamer:Calm1:4xCa2+ [cytosol]

Physical Entity
CaMKII dodecamer:Calm1:4xCa2+ [cytosol] (Rattus norvegicus)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
CaMKII autophosphorylates (Homo sapiens)
Authored
Orlic-Milacic, M  (2018-10-10)
Reviewed
Yi, F  (2018-11-02)
Hansen, KB  (2018-11-02)
Created
Orlic-Milacic, M  (2018-09-10)
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