Reactome | CaMKII binds activated GluN1:GluN2B (Grin1:Grin2b) NMDA receptor

CaMKII binds activated GluN1:GluN2B (Grin1:Grin2b) NMDA receptor

Stable Identifier

R-RNO-9618659

Type

Reaction [binding]

Species

Rattus norvegicus

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

General

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CaMKII binds activated GluN1:GluN2B (Grin1:Grin2b) NMDA receptor

Autophosphorylated, calmodulin-bound rat CaMKII binds to activated rat NMDA receptors that contain GluN2B (Grin2b) subunit (Strack and Colbran 1998, Shen and Meyer 1999). Rat CaMKII can bind to NMDA receptor-associated postsynaptic density (PSD) proteins irrespective of its phosphorylation status (Robison et al. 2005), but binding to activated calmodulin is needed for translocation of CaMKII from the cytosol to the postsynaptic density (PSD) (Shen and Meyer 1999).

Literature References

PubMed ID	Title	Journal	Year
10102820	Dynamic control of CaMKII translocation and localization in hippocampal neurons by NMDA receptor stimulation Shen, K, Meyer, T	Science	1999
16120608	Multivalent interactions of calcium/calmodulin-dependent protein kinase II with the postsynaptic density proteins NR2B, densin-180, and alpha-actinin-2 Robison, AJ, MacMillan, LB, Jiao, Y, Carmody, LC, Colbran, RJ, Bass, MA, Bartlett, RK	J. Biol. Chem.	2005
9694809	Autophosphorylation-dependent targeting of calcium/ calmodulin-dependent protein kinase II by the NR2B subunit of the N-methyl- D-aspartate receptor Colbran, RJ, Strack, S	J. Biol. Chem.	1998

Participants

Input

Output

Gly:L-Glu:Grin1:Grin2b NMDA receptor:p-T286-CaMKII dodecamer:Calm1:4xCa2+ [plasma membrane] (Rattus norvegicus)

Orthologous Events

CaMKII binds activated NMDA receptor (Homo sapiens)

Authored

Orlic-Milacic, M (2018-10-10)

Reviewed

Hansen, KB (2018-11-02)

Yi, F (2018-11-02)

Created

Orlic-Milacic, M (2018-09-11)

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