p-Creb, Ascl1, Tcf12, p300 bind the vgf promoter

Stable Identifier
R-RNO-9620716
Type
Reaction [binding]
Species
Rattus norvegicus
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
p-Creb, Ascl1, Tcf12, p300 bind the vgf promoter
Vgf expression in rat PC12 cells is governed in part by the binding of p-S133 Creb, Ascl1 (also known as Mash1) and Tcf12 (also known as Heb) to cognate binding sites in the proximal promoter. Tcf1, which acts as a Vgf repressor in non-neuronal tissue, binds to the E box and may heterodimerize with Ascl to weakly transactivate expression (Di Rocco et al, 1997; Mandolesi et al, 2002). p-Creb binding to a CRE site upstream of the transcriptional start site is required for NGF-responsive transcription, and may be aided by binding of an unidentified factor to an adjacent CCAAT site (D'Arcangelo et al, 1996; Mandolesi et al, 2002). The CRE- -binding complexes is also associated with p300 (Mandolesi et al, 2002).
Literature References
PubMed ID Title Journal Year
9032251 Interplay of the E box, the cyclic AMP response element, and HTF4/HEB in transcriptional regulation of the neurospecific, neurotrophin-inducible vgf gene

Di Rocco, G, Pennuto, M, Illi, B, Nasi, S, Trani, E, Mandolesi, G, Sirinian, MI, Levi, A, Filocamo, G, Jucker, R, Possenti, R, Canu, N, Rinaldi, AM

Mol. Cell. Biol. 1997
11755530 NGF-dependent and tissue-specific transcription of vgf is regulated by a CREB-p300 and bHLH factor interaction

Mandolesi, G, Gargano, S, Molfetta, R, Pennuto, M, Illi, B, Nasi, S, Levi, A, Jucker, R, Mosca, L, Soucek, L

FEBS Lett. 2002
8756618 Activation of codependent transcription factors is required for transcriptional induction of the vgf gene by nerve growth factor and Ras

D'Arcangelo, G, Salton, SR, Halegoua, S, Habas, R, Wang, S

Mol. Cell. Biol. 1996
Participants
Input
Output
Orthologous Events
p-CREB, ASCL1, TCF12, ATFs and p300 bind the VGF promoter (Homo sapiens)
Authored
Rothfels, K  (2019-08-16)
Reviewed
Aletta, J M  (2020-01-17)
Created
Rothfels, K  (2018-09-25)
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