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EGF-like ligands:p-6Y EGFR dimer [plasma membrane]
Stable Identifier
R-RNO-9624425
Type
Complex
Species
Rattus norvegicus
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Signal Transduction (Rattus norvegicus)
Intracellular signaling by second messengers (Rattus norvegicus)
PIP3 activates AKT signaling (Rattus norvegicus)
Negative regulation of the PI3K/AKT network (Rattus norvegicus)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Rattus norvegicus)
PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
Activator:PI3K [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Rattus norvegicus)
PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
Activator:PI3K [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Rattus norvegicus)
MAPK family signaling cascades (Rattus norvegicus)
MAPK1/MAPK3 signaling (Rattus norvegicus)
RAF/MAP kinase cascade (Rattus norvegicus)
RAS GEFs promote RAS nucleotide exchange (Rattus norvegicus)
RAS GEFs [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:GRB2:SOS1 [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1 [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Rattus norvegicus)
Signaling by Nuclear Receptors (Rattus norvegicus)
ESR-mediated signaling (Rattus norvegicus)
Extra-nuclear estrogen signaling (Rattus norvegicus)
PTK2 autophosphorylates downstream of EGFR (Rattus norvegicus)
EGF-like ligands:p-6Y EGFR dimer:p-Y397 PTK2 [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y EGFR:PTK2 [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Rattus norvegicus)
PTK2 binds activated EGFR (Rattus norvegicus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y EGFR:PTK2 [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Rattus norvegicus)
Signaling by Receptor Tyrosine Kinases (Rattus norvegicus)
Signaling by EGFR (Rattus norvegicus)
EGFR autophosphorylation (Rattus norvegicus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Rattus norvegicus)
EGFR downregulation (Rattus norvegicus)
Binding of CBL to EGFR (Rattus norvegicus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Rattus norvegicus)
CBL binds and ubiquitinates phosphorylated Sprouty (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:CBL:Ub-p-Y53/55-SPRY1/2 [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Rattus norvegicus)
CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Rattus norvegicus)
CBL ubiquitinates Sprouty (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:CBL:Ub-p-Y53/55-SPRY1/2 [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:CBL:p-Y53/55-SPRY1/2 [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Rattus norvegicus)
Localization of CBL:GRB2 to the membrane (Rattus norvegicus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Rattus norvegicus)
Phosphorylation of CBL (EGFR:CBL) (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Rattus norvegicus)
Phosphorylation of CBL (EGFR:GRB2:CBL) (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Rattus norvegicus)
EGFR interacts with phospholipase C-gamma (Rattus norvegicus)
Active PLC-gamma1 dissociates from EGFR (Rattus norvegicus)
EGF-like ligand:p-6Y-EGFR:p-Y472,771,783,1254-PLCG1 [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Rattus norvegicus)
EGFR activates PLC-gamma1 by phosphorylation (Rattus norvegicus)
EGF-like ligand:p-6Y-EGFR:p-Y472,771,783,1254-PLCG1 [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:PLCG1 [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Rattus norvegicus)
Phospholipase C-gamma1 binds to the activated EGF receptor (Rattus norvegicus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:PLCG1 [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Rattus norvegicus)
GAB1 signalosome (Rattus norvegicus)
Activation of SHP2 through the binding to phospho-Gab1 (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Rattus norvegicus)
Dephosphorylation of Gab1 by SHP2 (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-Y627,659-GAB1:SHP2 [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Rattus norvegicus)
Dephosphorylation of PAG by SHP2 (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Rattus norvegicus)
GAB1 phosphorylation by EGFR kinase (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:GRB2:GAB1 [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Rattus norvegicus)
GRB2:GAB1 binds to phosphorylated EGFR (Rattus norvegicus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:GRB2:GAB1 [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Rattus norvegicus)
PI3K binds to EGF:EGFR:GRB2:GAB1 (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Rattus norvegicus)
PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Rattus norvegicus)
SHP2 dephosphorylates Tyr 992 on EGFR (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Rattus norvegicus)
Sustained activation of SRC kinase by SHP2 (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Rattus norvegicus)
GRB2 events in EGFR signaling (Rattus norvegicus)
GRB2:SOS1 complex binds to EGF:EGFR complex (Rattus norvegicus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:GRB2:SOS1 [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Rattus norvegicus)
SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:GRB2:SOS1 [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Rattus norvegicus)
Phosphorylation of EGFR by SRC kinase (Rattus norvegicus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Rattus norvegicus)
SHC1 events in EGFR signaling (Rattus norvegicus)
GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1 [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1 [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Rattus norvegicus)
SHC1 binds to the phosphorylated EGF receptor:ligand complex (Rattus norvegicus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y EGFR:SHC1 [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Rattus norvegicus)
SHC1 phosphorylation by phosphorylated EGFR (Rattus norvegicus)
EGF-like ligands:p-6Y EGFR:SHC1 [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1 [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Rattus norvegicus)
SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1 [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Rattus norvegicus)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
x 2
EGF-like ligands [extracellular region]
(Rattus norvegicus)
x 2
phospho-p-6Y-EGFR [plasma membrane]
(Rattus norvegicus)
Participates
as an input of
PTK2 binds activated EGFR (Rattus norvegicus)
Binding of CBL to EGFR (Rattus norvegicus)
Localization of CBL:GRB2 to the membrane (Rattus norvegicus)
GRB2:SOS1 complex binds to EGF:EGFR complex (Rattus norvegicus)
SHC1 binds to the phosphorylated EGF receptor:ligand complex (Rattus norvegicus)
Phospholipase C-gamma1 binds to the activated EGF receptor (Rattus norvegicus)
GRB2:GAB1 binds to phosphorylated EGFR (Rattus norvegicus)
as a component of
EGF-like ligands:p-6Y EGFR:PTK2 [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y EGFR dimer:p-Y397 PTK2 [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-Y627,659-GAB1:SHP2 [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y EGFR:SHC1 [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:GRB2:SOS1 [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1 [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:PLCG1 [plasma membrane] (Rattus norvegicus)
EGF-like ligand:p-6Y-EGFR:p-Y472,771,783,1254-PLCG1 [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:GRB2:GAB1 [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Rattus norvegicus)
as an output of
Active PLC-gamma1 dissociates from EGFR (Rattus norvegicus)
EGFR autophosphorylation (Rattus norvegicus)
Phosphorylation of EGFR by SRC kinase (Rattus norvegicus)
Inferred From
EGF-like ligands:p-6Y EGFR dimer [plasma membrane]
(Homo sapiens)
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