MET channel transports cations from the extracellular region into the cytosol of stereocilia

Stable Identifier
R-RNO-9665067
Type
Reaction [transition]
Species
Rattus norvegicus
Compartment
plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
MET channel transports cations from the extracellular region into the cytosol of stereocilia
Deflection of the stereocilia by sound causes increased tension on Cdh23:Pcdh15, resulting in an increased probability of the open state of the MET channel (Beurg et al. 2006). The MET channel is relatively non-specific for cations and allows calcium ions and potassium ions to pass from the extracellular scala media to the cytosol of the inner hair cell (Beurg et al. 2006).
Literature References
PubMed ID Title Journal Year
17065441 A large-conductance calcium-selective mechanotransducer channel in mammalian cochlear hair cells

Hackney, CM, Evans, MG, Beurg, M, Fettiplace, R

J. Neurosci. 2006
Participants
Input
Output
Catalyst Activity

cation channel activity of MET channel [plasma membrane]

Physical Entity
MET channel [plasma membrane] (Rattus norvegicus)
Activity
cation channel activity (GO:0005261)
Orthologous Events
Mechanoelectrical transduction (MET) channel transports cations from the extracellular region into the cytosol of stereocilia of inner hair cell (Homo sapiens)
Authored
May, B  (2019-10-27)
Reviewed
Furness, DN  (2020-09-14)
Created
May, B  (2019-10-29)
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