Chrna9:Chrna10:AcCho transports calcium ions from the extracellular region to the cytosol

Stable Identifier
R-RNO-9667850
Type
Reaction [transition]
Species
Rattus norvegicus
Compartment
ReviewStatus
5/5
General
SVG |   | PPTX  | SBGN
Chrna9:Chrna10:AcCho transports calcium ions from the extracellular region to the cytosol
In response to binding acetylcholine (AcCho), the Chrna9:Chrna10 receptor transports calcium ions from the extracellular region to the cytosol (Elgoyhen et al. 1994, Verbitsky et al. 2000, Elgoyhen et al. 2001, Weisstaub et al. 2002, Gomez-Casati et al. 2005). Chrna9:Chrna10 receptors are clustered at cholinergic synapses in the basal region of outer hair cells (OHCs). The influx of calcium causes opening of SK2 channels (Kcnn2) and BK channels (Kcnma1:Kcnmb1), efflux of potassium ions, hyperpolarization, and inhibition of contraction of the OHCs.
Literature References
PubMed ID Title Journal Year
12117536 The alpha9alpha10 nicotinic acetylcholine receptor is permeable to and is modulated by divalent cations

Vetter, DE, Elgoyhen, AB, Weisstaub, N, Katz, E

Hear. Res. 2002
7954834 Alpha 9: an acetylcholine receptor with novel pharmacological properties expressed in rat cochlear hair cells

Elgoyhen, AB, Vetter, DE, Heinemann, S, Johnson, DS, Boulter, J

Cell 1994
15860528 Biophysical and pharmacological characterization of nicotinic cholinergic receptors in rat cochlear inner hair cells

Elgoyhen, AB, Fuchs, PA, Gómez-Casati, ME, Katz, E

J. Physiol. (Lond.) 2005
11044723 Mixed nicotinic-muscarinic properties of the alpha9 nicotinic cholinergic receptor

Elgoyhen, AB, Rothlin, CV, Verbitsky, M, Katz, E

Neuropharmacology 2000
11248107 alpha10: a determinant of nicotinic cholinergic receptor function in mammalian vestibular and cochlear mechanosensory hair cells

Elgoyhen, AB, Heinemann, SF, Vetter, DE, Rothlin, CV, Boulter, J, Katz, E

Proc. Natl. Acad. Sci. U.S.A. 2001
Participants
Catalyst Activity

calcium channel activity of Chrna9:Chrna10:AcCho [plasma membrane]

Orthologous Events
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