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phospho-K63polyUb-hp-IRAK1 [endosome membrane]
Stable Identifier
R-RNO-975112
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
endosome membrane
Synonyms
A0A0G2JYX9
Locations in the PathwayBrowser
Expand all
Immune System (Rattus norvegicus)
Innate Immune System (Rattus norvegicus)
Toll-like Receptor Cascades (Rattus norvegicus)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Rattus norvegicus)
MyD88 dependent cascade initiated on endosome (Rattus norvegicus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Rattus norvegicus)
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation (Rattus norvegicus)
NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9. (Rattus norvegicus)
K63-linked poly-Ub-p-3S,3T-IRAK1:TRAF6 [endosome membrane] (Rattus norvegicus)
phospho-K63polyUb-hp-IRAK1 [endosome membrane] (Rattus norvegicus)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [endosome membrane] (Rattus norvegicus)
K63-linked poly-Ub-p-3S,3T-IRAK1:TRAF6 [endosome membrane] (Rattus norvegicus)
phospho-K63polyUb-hp-IRAK1 [endosome membrane] (Rattus norvegicus)
Toll Like Receptor 9 (TLR9) Cascade (Rattus norvegicus)
MyD88 dependent cascade initiated on endosome (Rattus norvegicus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Rattus norvegicus)
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation (Rattus norvegicus)
NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9. (Rattus norvegicus)
K63-linked poly-Ub-p-3S,3T-IRAK1:TRAF6 [endosome membrane] (Rattus norvegicus)
phospho-K63polyUb-hp-IRAK1 [endosome membrane] (Rattus norvegicus)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [endosome membrane] (Rattus norvegicus)
K63-linked poly-Ub-p-3S,3T-IRAK1:TRAF6 [endosome membrane] (Rattus norvegicus)
phospho-K63polyUb-hp-IRAK1 [endosome membrane] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:A0A0G2JYX9
Reference Genes
BioGPS Gene:363520
ENSEMBL:ENSRNOG00000060869
ENSEMBL:ENSRNOG00000060869.2
Monarch:363520
NCBI Gene:363520
Reference Transcript
RefSeq:XM_006229598.2
Other Identifiers
10940296
1373379_at
1394991_at
17879951
363520
5628739
5632056
5676323
5801606
5811142
5826030
5831432
5877501
5884977
5965069
5984965
6067909
6094720
6131089
6203680
6278092
6298705
6318316
6352563
6434505
6463199
6597037
A_44_P532352
GE18534
GO:0001959
GO:0002376
GO:0003824
GO:0004672
GO:0004674
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005829
GO:0006468
GO:0007155
GO:0007165
GO:0007249
GO:0009986
GO:0016301
GO:0016740
GO:0019901
GO:0023052
GO:0031663
GO:0032481
GO:0032496
GO:0032991
GO:0034134
GO:0036211
GO:0038172
GO:0042802
GO:0042803
GO:0043123
GO:0043226
GO:0046982
GO:0060337
GO:0070498
GO:0070555
GO:0098542
GO:0140096
GO:1904996
ILMN_1651046
PH_rn_0001813
rc_AA848895_at
rc_AI136692_at
Participates
as a component of
K63-linked poly-Ub-p-3S,3T-IRAK1:TRAF6 [endosome membrane] (Rattus norvegicus)
Other forms of this molecule
phospho-p-S376,T387-IRAK1 [cytosol]
phospho-p-S,T-IRAK1 [cytosol]
phospho-K63polyUb-hp-IRAK1 [cytosol]
phospho-p-2S,S376,T,T209,T387-IRAK1 [endosome membrane]
phospho-p-2S,S376,T,T209,T387-IRAK1 [plasma membrane]
phospho-p-2S,S376,T,T209,T387-IRAK1 [cytosol]
IRAK1 [cytosol]
Inferred From
K63polyUb-hp-IRAK1 [endosome membrane]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-threonine at 209 (in Homo sapiens)
Coordinate
209
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-serine at 376 (in Homo sapiens)
Coordinate
376
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-threonine at 387 (in Homo sapiens)
Coordinate
387
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-threonine at unknown position
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-serine at unknown position
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at unknown position
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
ubiquitinylated lysine (K63polyUb [endosome membrane]) at 134 (in Homo sapiens)
Coordinate
134
Modification
K63polyUb [endosome membrane]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Name
ubiquitinylated lysine (K63polyUb [endosome membrane]) at 180 (in Homo sapiens)
Coordinate
180
Modification
K63polyUb [endosome membrane]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
RefSeq
XP_006229660.1
Ensembl
ENSRNOT00000092207
,
ENSRNOP00000070832
,
ENSRNOG00000060869
RGD
1563841
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