Reactome: A Curated Pathway Database

Signalosomes assemble at the activated BCR

Stable Identifier
R-RNO-983704
Type
Reaction [BlackBoxEvent]
Species
Rattus norvegicus
Compartment
Synonyms
Assembly of Signalosomes at the Activated B Cell Receptor
Locations in the PathwayBrowser
Summation

This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.

Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
protein tyrosine kinase activity of Antigen:p-BCR:p-SYK:p-BLNK [plasma membrane] Antigen:p-BCR:p-SYK:p-BLNK [plasma membrane] protein tyrosine kinase activity (0004713)
phosphatidylinositol-4,5-bisphosphate 3-kinase activity of PIK3CD:PIK3R1 [plasma membrane] PIK3CD:PIK3R1 [plasma membrane] phosphatidylinositol-4,5-bisphosphate 3-kinase activity (0046934)
protein tyrosine kinase activity of Homologues of BTK [cytosol] Homologues of BTK [cytosol] protein tyrosine kinase activity (0004713)
Inferred From