Reactome | Alkal2 [extracellular region]

Alkal2 [extracellular region]

Stable Identifier

R-RNO-9842575

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

extracellular region

Synonyms

HC-ALKAL2, B2RZ42

Locations in the PathwayBrowser

Expand all

Signal Transduction (Rattus norvegicus)

- Signaling by Receptor Tyrosine Kinases (Rattus norvegicus)
  - Signaling by ALK (Rattus norvegicus)
    - ALK autophosphorylation (Rattus norvegicus)
      - ALK dimer:ligand:type I ALK binding TKI [plasma membrane] (Rattus norvegicus)
        
        ligand-bound ALK dimer [plasma membrane] (Rattus norvegicus)
        
        ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Rattus norvegicus)
        
        ALKAL2:(ALKAL1) [extracellular region] (Rattus norvegicus)
        
        ALKAL2 dimer [extracellular region] (Rattus norvegicus)
        
        Alkal2 [extracellular region] (Rattus norvegicus)
      - Active ALK dimer [plasma membrane] (Rattus norvegicus)
        
        p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Rattus norvegicus)
        
        ALKAL2:(ALKAL1) [extracellular region] (Rattus norvegicus)
        
        ALKAL2 dimer [extracellular region] (Rattus norvegicus)
        
        Alkal2 [extracellular region] (Rattus norvegicus)
      - ligand-bound ALK dimer [plasma membrane] (Rattus norvegicus)
        
        ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Rattus norvegicus)
        
        ALKAL2:(ALKAL1) [extracellular region] (Rattus norvegicus)
        
        ALKAL2 dimer [extracellular region] (Rattus norvegicus)
        
        Alkal2 [extracellular region] (Rattus norvegicus)
    - ALK binds ALKAL ligand (Rattus norvegicus)
      - ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Rattus norvegicus)
        
        ALKAL2:(ALKAL1) [extracellular region] (Rattus norvegicus)
        
        ALKAL2 dimer [extracellular region] (Rattus norvegicus)
        
        Alkal2 [extracellular region] (Rattus norvegicus)
      - ALKAL2:(ALKAL1) [extracellular region] (Rattus norvegicus)
        
        ALKAL2 dimer [extracellular region] (Rattus norvegicus)
        
        Alkal2 [extracellular region] (Rattus norvegicus)
    - Active ALK binds JAK3 (Rattus norvegicus)
      - Active ALK dimer [plasma membrane] (Rattus norvegicus)
        
        p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Rattus norvegicus)
        
        ALKAL2:(ALKAL1) [extracellular region] (Rattus norvegicus)
        
        ALKAL2 dimer [extracellular region] (Rattus norvegicus)
        
        Alkal2 [extracellular region] (Rattus norvegicus)
      - Active ALK:JAK3 [plasma membrane] (Rattus norvegicus)
        
        Active ALK dimer [plasma membrane] (Rattus norvegicus)
        
        p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Rattus norvegicus)
        
        ALKAL2:(ALKAL1) [extracellular region] (Rattus norvegicus)
        
        ALKAL2 dimer [extracellular region] (Rattus norvegicus)
        
        Alkal2 [extracellular region] (Rattus norvegicus)
    - Active ALK binds PLCG1 (Rattus norvegicus)
      - Active ALK dimer [plasma membrane] (Rattus norvegicus)
        
        p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Rattus norvegicus)
        
        ALKAL2:(ALKAL1) [extracellular region] (Rattus norvegicus)
        
        ALKAL2 dimer [extracellular region] (Rattus norvegicus)
        
        Alkal2 [extracellular region] (Rattus norvegicus)
      - Active ALK:PLCG1 [plasma membrane] (Rattus norvegicus)
        
        Active ALK dimer [plasma membrane] (Rattus norvegicus)
        
        p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Rattus norvegicus)
        
        ALKAL2:(ALKAL1) [extracellular region] (Rattus norvegicus)
        
        ALKAL2 dimer [extracellular region] (Rattus norvegicus)
        
        Alkal2 [extracellular region] (Rattus norvegicus)
    - Active ALK binds SHC1 (Rattus norvegicus)
      - Active ALK dimer [plasma membrane] (Rattus norvegicus)
        
        p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Rattus norvegicus)
        
        ALKAL2:(ALKAL1) [extracellular region] (Rattus norvegicus)
        
        ALKAL2 dimer [extracellular region] (Rattus norvegicus)
        
        Alkal2 [extracellular region] (Rattus norvegicus)
      - Active ALK:SHC1 [plasma membrane] (Rattus norvegicus)
        
        Active ALK dimer [plasma membrane] (Rattus norvegicus)
        
        p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Rattus norvegicus)
        
        ALKAL2:(ALKAL1) [extracellular region] (Rattus norvegicus)
        
        ALKAL2 dimer [extracellular region] (Rattus norvegicus)
        
        Alkal2 [extracellular region] (Rattus norvegicus)
    - Active ALK dimer binds IRS1 (Rattus norvegicus)
      - Active ALK dimer [plasma membrane] (Rattus norvegicus)
        
        p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Rattus norvegicus)
        
        ALKAL2:(ALKAL1) [extracellular region] (Rattus norvegicus)
        
        ALKAL2 dimer [extracellular region] (Rattus norvegicus)
        
        Alkal2 [extracellular region] (Rattus norvegicus)
      - Active ALK:IRS1 [plasma membrane] (Rattus norvegicus)
        
        Active ALK dimer [plasma membrane] (Rattus norvegicus)
        
        p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Rattus norvegicus)
        
        ALKAL2:(ALKAL1) [extracellular region] (Rattus norvegicus)
        
        ALKAL2 dimer [extracellular region] (Rattus norvegicus)
        
        Alkal2 [extracellular region] (Rattus norvegicus)
    - Active ALK phosphorylates IRS1 (Rattus norvegicus)
      - Active ALK:IRS1 [plasma membrane] (Rattus norvegicus)
        
        Active ALK dimer [plasma membrane] (Rattus norvegicus)
        
        p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Rattus norvegicus)
        
        ALKAL2:(ALKAL1) [extracellular region] (Rattus norvegicus)
        
        ALKAL2 dimer [extracellular region] (Rattus norvegicus)
        
        Alkal2 [extracellular region] (Rattus norvegicus)
      - Active ALK:pY-IRS1 [plasma membrane] (Rattus norvegicus)
        
        Active ALK dimer [plasma membrane] (Rattus norvegicus)
        
        p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Rattus norvegicus)
        
        ALKAL2:(ALKAL1) [extracellular region] (Rattus norvegicus)
        
        ALKAL2 dimer [extracellular region] (Rattus norvegicus)
        
        Alkal2 [extracellular region] (Rattus norvegicus)
    - Active ALK phosphorylates JAK3 (Rattus norvegicus)
      - Active ALK:JAK3 [plasma membrane] (Rattus norvegicus)
        
        Active ALK dimer [plasma membrane] (Rattus norvegicus)
        
        p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Rattus norvegicus)
        
        ALKAL2:(ALKAL1) [extracellular region] (Rattus norvegicus)
        
        ALKAL2 dimer [extracellular region] (Rattus norvegicus)
        
        Alkal2 [extracellular region] (Rattus norvegicus)
      - Active ALK:p-Y980 JAK3 [plasma membrane] (Rattus norvegicus)
        
        Active ALK dimer [plasma membrane] (Rattus norvegicus)
        
        p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Rattus norvegicus)
        
        ALKAL2:(ALKAL1) [extracellular region] (Rattus norvegicus)
        
        ALKAL2 dimer [extracellular region] (Rattus norvegicus)
        
        Alkal2 [extracellular region] (Rattus norvegicus)
    - Active ALK phosphorylates PLCG1 (Rattus norvegicus)
      - Active ALK:PLCG1 [plasma membrane] (Rattus norvegicus)
        
        Active ALK dimer [plasma membrane] (Rattus norvegicus)
        
        p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Rattus norvegicus)
        
        ALKAL2:(ALKAL1) [extracellular region] (Rattus norvegicus)
        
        ALKAL2 dimer [extracellular region] (Rattus norvegicus)
        
        Alkal2 [extracellular region] (Rattus norvegicus)
      - Active ALK:p-4Y PLCG1 [plasma membrane] (Rattus norvegicus)
        
        Active ALK dimer [plasma membrane] (Rattus norvegicus)
        
        p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Rattus norvegicus)
        
        ALKAL2:(ALKAL1) [extracellular region] (Rattus norvegicus)
        
        ALKAL2 dimer [extracellular region] (Rattus norvegicus)
        
        Alkal2 [extracellular region] (Rattus norvegicus)
    - Active ALK phosphorylates SHC1 (Rattus norvegicus)
      - Active ALK:SHC1 [plasma membrane] (Rattus norvegicus)
        
        Active ALK dimer [plasma membrane] (Rattus norvegicus)
        
        p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Rattus norvegicus)
        
        ALKAL2:(ALKAL1) [extracellular region] (Rattus norvegicus)
        
        ALKAL2 dimer [extracellular region] (Rattus norvegicus)
        
        Alkal2 [extracellular region] (Rattus norvegicus)
      - Active ALK:p-3Y SHC1 [plasma membrane] (Rattus norvegicus)
        
        Active ALK dimer [plasma membrane] (Rattus norvegicus)
        
        p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Rattus norvegicus)
        
        ALKAL2:(ALKAL1) [extracellular region] (Rattus norvegicus)
        
        ALKAL2 dimer [extracellular region] (Rattus norvegicus)
        
        Alkal2 [extracellular region] (Rattus norvegicus)
    - Active ALK recruits PI3K (Rattus norvegicus)
      - Active ALK dimer [plasma membrane] (Rattus norvegicus)
        
        p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Rattus norvegicus)
        
        ALKAL2:(ALKAL1) [extracellular region] (Rattus norvegicus)
        
        ALKAL2 dimer [extracellular region] (Rattus norvegicus)
        
        Alkal2 [extracellular region] (Rattus norvegicus)
      - Active ALK:PI3K [plasma membrane] (Rattus norvegicus)
        
        Active ALK dimer [plasma membrane] (Rattus norvegicus)
        
        p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Rattus norvegicus)
        
        ALKAL2:(ALKAL1) [extracellular region] (Rattus norvegicus)
        
        ALKAL2 dimer [extracellular region] (Rattus norvegicus)
        
        Alkal2 [extracellular region] (Rattus norvegicus)
    - Liganded-ALK dimer binds type I ALK-binding TKIs (Rattus norvegicus)
      - ALK dimer:ligand:type I ALK binding TKI [plasma membrane] (Rattus norvegicus)
        
        ligand-bound ALK dimer [plasma membrane] (Rattus norvegicus)
        
        ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Rattus norvegicus)
        
        ALKAL2:(ALKAL1) [extracellular region] (Rattus norvegicus)
        
        ALKAL2 dimer [extracellular region] (Rattus norvegicus)
        
        Alkal2 [extracellular region] (Rattus norvegicus)
      - ligand-bound ALK dimer [plasma membrane] (Rattus norvegicus)
        
        ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Rattus norvegicus)
        
        ALKAL2:(ALKAL1) [extracellular region] (Rattus norvegicus)
        
        ALKAL2 dimer [extracellular region] (Rattus norvegicus)
        
        Alkal2 [extracellular region] (Rattus norvegicus)
    - PI3K synthesizes PIP3 downstream of ALK (Rattus norvegicus)
      - Active ALK:PI3K [plasma membrane] (Rattus norvegicus)
        
        Active ALK dimer [plasma membrane] (Rattus norvegicus)
        
        p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Rattus norvegicus)
        
        ALKAL2:(ALKAL1) [extracellular region] (Rattus norvegicus)
        
        ALKAL2 dimer [extracellular region] (Rattus norvegicus)
        
        Alkal2 [extracellular region] (Rattus norvegicus)
    - PTPN6 dephosphorylates JAK3 (Rattus norvegicus)
      - Active ALK:JAK3 [plasma membrane] (Rattus norvegicus)
        
        Active ALK dimer [plasma membrane] (Rattus norvegicus)
        
        p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Rattus norvegicus)
        
        ALKAL2:(ALKAL1) [extracellular region] (Rattus norvegicus)
        
        ALKAL2 dimer [extracellular region] (Rattus norvegicus)
        
        Alkal2 [extracellular region] (Rattus norvegicus)
      - Active ALK:p-Y980 JAK3 [plasma membrane] (Rattus norvegicus)
        
        Active ALK dimer [plasma membrane] (Rattus norvegicus)
        
        p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Rattus norvegicus)
        
        ALKAL2:(ALKAL1) [extracellular region] (Rattus norvegicus)
        
        ALKAL2 dimer [extracellular region] (Rattus norvegicus)
        
        Alkal2 [extracellular region] (Rattus norvegicus)
    - STAT3 is phosphorylated downstream of active ALK (Rattus norvegicus)
      - Active ALK dimer [plasma membrane] (Rattus norvegicus)
        
        p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Rattus norvegicus)
        
        ALKAL2:(ALKAL1) [extracellular region] (Rattus norvegicus)
        
        ALKAL2 dimer [extracellular region] (Rattus norvegicus)
        
        Alkal2 [extracellular region] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:B2RZ42

Gene Names

Alkal2

Reference Genes

BioGPS Gene:679566 Alkal2

ENSEMBL:ENSRNOG00000005154

ENSEMBL:ENSRNOG00055005868

ENSEMBL:ENSRNOG00060008036

ENSEMBL:ENSRNOG00065010779

Monarch:679566 Alkal2

NCBI Gene:679566 Alkal2

UCSC:B2RZ42 Alkal2

Reference Transcript

RefSeq:NM_001109372.1 Alkal2

Other Identifiers

10884056

17815253

5710441

5774139

5996070

6198273

6733104

679566

A_64_P048055

A_64_P119680

GO:0005125

GO:0005576

GO:0005615

GO:0007169

GO:0010976

GO:0023052

GO:0030154

GO:0030297

GO:0030298

GO:0030971

GO:0048018

GO:0048856

GO:0070374

GO:0070378

GO:0098772

PH_rn_0013026

Participates

as a component of

ALKAL2 dimer [extracellular region] (Rattus norvegicus)

Other forms of this molecule

Alkal2 [extracellular region]

Inferred From

HC-ALKAL2 [extracellular region] (Homo sapiens)

Modified Residues

Name

Inter-chain Crosslink via L-cystine (cross-link) at 66 and 66 (in Homo sapiens)

Coordinate

PsiMod Name

L-cystine (cross-link)

PsiMod Definition

A protein modification that effectively cross-links two L-cysteine residues to form L-cystine.

Cross References

ENSEMBL

ENSRNOP00000006921, ENSRNOT00000006921

PRO

B2RZ42

RGD

1587117

Cite Us!