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Alkal1 [extracellular region]
Stable Identifier
R-RNO-9842576
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
extracellular region
Synonyms
ALKAL1, M0R9C8
Locations in the PathwayBrowser
Expand all
Signal Transduction (Rattus norvegicus)
Signaling by Receptor Tyrosine Kinases (Rattus norvegicus)
Signaling by ALK (Rattus norvegicus)
ALK autophosphorylation (Rattus norvegicus)
ALK dimer:ligand:type I ALK binding TKI [plasma membrane] (Rattus norvegicus)
ligand-bound ALK dimer [plasma membrane] (Rattus norvegicus)
ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Rattus norvegicus)
ALKAL2:(ALKAL1) [extracellular region] (Rattus norvegicus)
Alkal1 [extracellular region] (Rattus norvegicus)
Active ALK dimer [plasma membrane] (Rattus norvegicus)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Rattus norvegicus)
ALKAL2:(ALKAL1) [extracellular region] (Rattus norvegicus)
Alkal1 [extracellular region] (Rattus norvegicus)
ligand-bound ALK dimer [plasma membrane] (Rattus norvegicus)
ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Rattus norvegicus)
ALKAL2:(ALKAL1) [extracellular region] (Rattus norvegicus)
Alkal1 [extracellular region] (Rattus norvegicus)
ALK binds ALKAL ligand (Rattus norvegicus)
ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Rattus norvegicus)
ALKAL2:(ALKAL1) [extracellular region] (Rattus norvegicus)
Alkal1 [extracellular region] (Rattus norvegicus)
ALKAL2:(ALKAL1) [extracellular region] (Rattus norvegicus)
Alkal1 [extracellular region] (Rattus norvegicus)
Active ALK binds JAK3 (Rattus norvegicus)
Active ALK dimer [plasma membrane] (Rattus norvegicus)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Rattus norvegicus)
ALKAL2:(ALKAL1) [extracellular region] (Rattus norvegicus)
Alkal1 [extracellular region] (Rattus norvegicus)
Active ALK:JAK3 [plasma membrane] (Rattus norvegicus)
Active ALK dimer [plasma membrane] (Rattus norvegicus)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Rattus norvegicus)
ALKAL2:(ALKAL1) [extracellular region] (Rattus norvegicus)
Alkal1 [extracellular region] (Rattus norvegicus)
Active ALK binds PLCG1 (Rattus norvegicus)
Active ALK dimer [plasma membrane] (Rattus norvegicus)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Rattus norvegicus)
ALKAL2:(ALKAL1) [extracellular region] (Rattus norvegicus)
Alkal1 [extracellular region] (Rattus norvegicus)
Active ALK:PLCG1 [plasma membrane] (Rattus norvegicus)
Active ALK dimer [plasma membrane] (Rattus norvegicus)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Rattus norvegicus)
ALKAL2:(ALKAL1) [extracellular region] (Rattus norvegicus)
Alkal1 [extracellular region] (Rattus norvegicus)
Active ALK binds SHC1 (Rattus norvegicus)
Active ALK dimer [plasma membrane] (Rattus norvegicus)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Rattus norvegicus)
ALKAL2:(ALKAL1) [extracellular region] (Rattus norvegicus)
Alkal1 [extracellular region] (Rattus norvegicus)
Active ALK:SHC1 [plasma membrane] (Rattus norvegicus)
Active ALK dimer [plasma membrane] (Rattus norvegicus)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Rattus norvegicus)
ALKAL2:(ALKAL1) [extracellular region] (Rattus norvegicus)
Alkal1 [extracellular region] (Rattus norvegicus)
Active ALK dimer binds IRS1 (Rattus norvegicus)
Active ALK dimer [plasma membrane] (Rattus norvegicus)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Rattus norvegicus)
ALKAL2:(ALKAL1) [extracellular region] (Rattus norvegicus)
Alkal1 [extracellular region] (Rattus norvegicus)
Active ALK:IRS1 [plasma membrane] (Rattus norvegicus)
Active ALK dimer [plasma membrane] (Rattus norvegicus)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Rattus norvegicus)
ALKAL2:(ALKAL1) [extracellular region] (Rattus norvegicus)
Alkal1 [extracellular region] (Rattus norvegicus)
Active ALK phosphorylates IRS1 (Rattus norvegicus)
Active ALK:IRS1 [plasma membrane] (Rattus norvegicus)
Active ALK dimer [plasma membrane] (Rattus norvegicus)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Rattus norvegicus)
ALKAL2:(ALKAL1) [extracellular region] (Rattus norvegicus)
Alkal1 [extracellular region] (Rattus norvegicus)
Active ALK:pY-IRS1 [plasma membrane] (Rattus norvegicus)
Active ALK dimer [plasma membrane] (Rattus norvegicus)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Rattus norvegicus)
ALKAL2:(ALKAL1) [extracellular region] (Rattus norvegicus)
Alkal1 [extracellular region] (Rattus norvegicus)
Active ALK phosphorylates JAK3 (Rattus norvegicus)
Active ALK:JAK3 [plasma membrane] (Rattus norvegicus)
Active ALK dimer [plasma membrane] (Rattus norvegicus)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Rattus norvegicus)
ALKAL2:(ALKAL1) [extracellular region] (Rattus norvegicus)
Alkal1 [extracellular region] (Rattus norvegicus)
Active ALK:p-Y980 JAK3 [plasma membrane] (Rattus norvegicus)
Active ALK dimer [plasma membrane] (Rattus norvegicus)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Rattus norvegicus)
ALKAL2:(ALKAL1) [extracellular region] (Rattus norvegicus)
Alkal1 [extracellular region] (Rattus norvegicus)
Active ALK phosphorylates PLCG1 (Rattus norvegicus)
Active ALK:PLCG1 [plasma membrane] (Rattus norvegicus)
Active ALK dimer [plasma membrane] (Rattus norvegicus)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Rattus norvegicus)
ALKAL2:(ALKAL1) [extracellular region] (Rattus norvegicus)
Alkal1 [extracellular region] (Rattus norvegicus)
Active ALK:p-4Y PLCG1 [plasma membrane] (Rattus norvegicus)
Active ALK dimer [plasma membrane] (Rattus norvegicus)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Rattus norvegicus)
ALKAL2:(ALKAL1) [extracellular region] (Rattus norvegicus)
Alkal1 [extracellular region] (Rattus norvegicus)
Active ALK phosphorylates SHC1 (Rattus norvegicus)
Active ALK:SHC1 [plasma membrane] (Rattus norvegicus)
Active ALK dimer [plasma membrane] (Rattus norvegicus)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Rattus norvegicus)
ALKAL2:(ALKAL1) [extracellular region] (Rattus norvegicus)
Alkal1 [extracellular region] (Rattus norvegicus)
Active ALK:p-3Y SHC1 [plasma membrane] (Rattus norvegicus)
Active ALK dimer [plasma membrane] (Rattus norvegicus)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Rattus norvegicus)
ALKAL2:(ALKAL1) [extracellular region] (Rattus norvegicus)
Alkal1 [extracellular region] (Rattus norvegicus)
Active ALK recruits PI3K (Rattus norvegicus)
Active ALK dimer [plasma membrane] (Rattus norvegicus)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Rattus norvegicus)
ALKAL2:(ALKAL1) [extracellular region] (Rattus norvegicus)
Alkal1 [extracellular region] (Rattus norvegicus)
Active ALK:PI3K [plasma membrane] (Rattus norvegicus)
Active ALK dimer [plasma membrane] (Rattus norvegicus)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Rattus norvegicus)
ALKAL2:(ALKAL1) [extracellular region] (Rattus norvegicus)
Alkal1 [extracellular region] (Rattus norvegicus)
Liganded-ALK dimer binds type I ALK-binding TKIs (Rattus norvegicus)
ALK dimer:ligand:type I ALK binding TKI [plasma membrane] (Rattus norvegicus)
ligand-bound ALK dimer [plasma membrane] (Rattus norvegicus)
ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Rattus norvegicus)
ALKAL2:(ALKAL1) [extracellular region] (Rattus norvegicus)
Alkal1 [extracellular region] (Rattus norvegicus)
ligand-bound ALK dimer [plasma membrane] (Rattus norvegicus)
ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Rattus norvegicus)
ALKAL2:(ALKAL1) [extracellular region] (Rattus norvegicus)
Alkal1 [extracellular region] (Rattus norvegicus)
PI3K synthesizes PIP3 downstream of ALK (Rattus norvegicus)
Active ALK:PI3K [plasma membrane] (Rattus norvegicus)
Active ALK dimer [plasma membrane] (Rattus norvegicus)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Rattus norvegicus)
ALKAL2:(ALKAL1) [extracellular region] (Rattus norvegicus)
Alkal1 [extracellular region] (Rattus norvegicus)
PTPN6 dephosphorylates JAK3 (Rattus norvegicus)
Active ALK:JAK3 [plasma membrane] (Rattus norvegicus)
Active ALK dimer [plasma membrane] (Rattus norvegicus)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Rattus norvegicus)
ALKAL2:(ALKAL1) [extracellular region] (Rattus norvegicus)
Alkal1 [extracellular region] (Rattus norvegicus)
Active ALK:p-Y980 JAK3 [plasma membrane] (Rattus norvegicus)
Active ALK dimer [plasma membrane] (Rattus norvegicus)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Rattus norvegicus)
ALKAL2:(ALKAL1) [extracellular region] (Rattus norvegicus)
Alkal1 [extracellular region] (Rattus norvegicus)
STAT3 is phosphorylated downstream of active ALK (Rattus norvegicus)
Active ALK dimer [plasma membrane] (Rattus norvegicus)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Rattus norvegicus)
ALKAL2:(ALKAL1) [extracellular region] (Rattus norvegicus)
Alkal1 [extracellular region] (Rattus norvegicus)
Signaling by LTK (Rattus norvegicus)
Active LTK binds GRB2:TNK2 (Rattus norvegicus)
Active LTK:GRB2:TNK2 [plasma membrane] (Rattus norvegicus)
p-5Y LTK dimer:ALKAL1,2 [plasma membrane] (Rattus norvegicus)
ALKAL1,2 [extracellular region] (Rattus norvegicus)
Alkal1 [extracellular region] (Rattus norvegicus)
p-5Y LTK dimer:ALKAL1,2 [plasma membrane] (Rattus norvegicus)
ALKAL1,2 [extracellular region] (Rattus norvegicus)
Alkal1 [extracellular region] (Rattus norvegicus)
Active LTK binds IRS1 (Rattus norvegicus)
Active LTK:IRS1 [plasma membrane] (Rattus norvegicus)
p-5Y LTK dimer:ALKAL1,2 [plasma membrane] (Rattus norvegicus)
ALKAL1,2 [extracellular region] (Rattus norvegicus)
Alkal1 [extracellular region] (Rattus norvegicus)
p-5Y LTK dimer:ALKAL1,2 [plasma membrane] (Rattus norvegicus)
ALKAL1,2 [extracellular region] (Rattus norvegicus)
Alkal1 [extracellular region] (Rattus norvegicus)
Active LTK phosphorylates IRS1 (Rattus norvegicus)
Active LTK:IRS1 [plasma membrane] (Rattus norvegicus)
p-5Y LTK dimer:ALKAL1,2 [plasma membrane] (Rattus norvegicus)
ALKAL1,2 [extracellular region] (Rattus norvegicus)
Alkal1 [extracellular region] (Rattus norvegicus)
Active LTK:p-Y IRS1 [plasma membrane] (Rattus norvegicus)
p-5Y LTK dimer:ALKAL1,2 [plasma membrane] (Rattus norvegicus)
ALKAL1,2 [extracellular region] (Rattus norvegicus)
Alkal1 [extracellular region] (Rattus norvegicus)
Active LTK receptor binds PI3K (Rattus norvegicus)
p-5Y LTK dimer:ALKAL1,2 [plasma membrane] (Rattus norvegicus)
ALKAL1,2 [extracellular region] (Rattus norvegicus)
Alkal1 [extracellular region] (Rattus norvegicus)
p-5Y LTK dimer:ALKAL1,2:PI3K [plasma membrane] (Rattus norvegicus)
p-5Y LTK dimer:ALKAL1,2 [plasma membrane] (Rattus norvegicus)
ALKAL1,2 [extracellular region] (Rattus norvegicus)
Alkal1 [extracellular region] (Rattus norvegicus)
Active LTK receptor binds SHC1 (Rattus norvegicus)
Active LTK:SHC1 [plasma membrane] (Rattus norvegicus)
p-5Y LTK dimer:ALKAL1,2 [plasma membrane] (Rattus norvegicus)
ALKAL1,2 [extracellular region] (Rattus norvegicus)
Alkal1 [extracellular region] (Rattus norvegicus)
p-5Y LTK dimer:ALKAL1,2 [plasma membrane] (Rattus norvegicus)
ALKAL1,2 [extracellular region] (Rattus norvegicus)
Alkal1 [extracellular region] (Rattus norvegicus)
Active LTK receptor phosphorylates SHC1 (Rattus norvegicus)
Active LTK:SHC1 [plasma membrane] (Rattus norvegicus)
p-5Y LTK dimer:ALKAL1,2 [plasma membrane] (Rattus norvegicus)
ALKAL1,2 [extracellular region] (Rattus norvegicus)
Alkal1 [extracellular region] (Rattus norvegicus)
Active LTK:p-3Y SHC1 [plasma membrane] (Rattus norvegicus)
p-5Y LTK dimer:ALKAL1,2 [plasma membrane] (Rattus norvegicus)
ALKAL1,2 [extracellular region] (Rattus norvegicus)
Alkal1 [extracellular region] (Rattus norvegicus)
Active LTK recruits GRB2:SOS1 (Rattus norvegicus)
Active LTK:p-3Y SHC1 [plasma membrane] (Rattus norvegicus)
p-5Y LTK dimer:ALKAL1,2 [plasma membrane] (Rattus norvegicus)
ALKAL1,2 [extracellular region] (Rattus norvegicus)
Alkal1 [extracellular region] (Rattus norvegicus)
Active LTK:p-3Y SHC1:GRB2:SOS1 [plasma membrane] (Rattus norvegicus)
p-5Y LTK dimer:ALKAL1,2 [plasma membrane] (Rattus norvegicus)
ALKAL1,2 [extracellular region] (Rattus norvegicus)
Alkal1 [extracellular region] (Rattus norvegicus)
Autophosphorylation of LTK dimer:ALKAL1,2 (Rattus norvegicus)
LTK dimer:ALKAL1,2 [plasma membrane] (Rattus norvegicus)
ALKAL1,2 [extracellular region] (Rattus norvegicus)
Alkal1 [extracellular region] (Rattus norvegicus)
p-5Y LTK dimer:ALKAL1,2 [plasma membrane] (Rattus norvegicus)
ALKAL1,2 [extracellular region] (Rattus norvegicus)
Alkal1 [extracellular region] (Rattus norvegicus)
IRS1 recruits GRB2 to active LTK (Rattus norvegicus)
Active LTK:p-Y IRS1 [plasma membrane] (Rattus norvegicus)
p-5Y LTK dimer:ALKAL1,2 [plasma membrane] (Rattus norvegicus)
ALKAL1,2 [extracellular region] (Rattus norvegicus)
Alkal1 [extracellular region] (Rattus norvegicus)
Active LTK:p-Y IRS1:GRB2 [plasma membrane] (Rattus norvegicus)
p-5Y LTK dimer:ALKAL1,2 [plasma membrane] (Rattus norvegicus)
ALKAL1,2 [extracellular region] (Rattus norvegicus)
Alkal1 [extracellular region] (Rattus norvegicus)
LTK binds ALKAL ligand (Rattus norvegicus)
ALKAL1,2 [extracellular region] (Rattus norvegicus)
Alkal1 [extracellular region] (Rattus norvegicus)
LTK dimer:ALKAL1,2 [plasma membrane] (Rattus norvegicus)
ALKAL1,2 [extracellular region] (Rattus norvegicus)
Alkal1 [extracellular region] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:M0R9C8
Gene Names
Alkal1
Reference Genes
BioGPS Gene:100910984 Alkal1
ENSEMBL:ENSRNOG00000048703
ENSEMBL:ENSRNOG00000048703.2 Alkal1
KEGG Gene (Rattus norvegicus):100910984 Alkal1
Monarch:100910984 Alkal1
NCBI Gene:100910984 Alkal1
Reference Transcript
RefSeq:NM_001302143.1 Alkal1
Other Identifiers
100910984
10875178
5729421
5755795
5947978
6099801
6493185
A_64_P135639
GO:0005125
GO:0005576
GO:0005615
GO:0007169
GO:0010976
GO:0023052
GO:0030154
GO:0030297
GO:0030298
GO:0030971
GO:0048018
GO:0048856
GO:0070374
GO:0070378
GO:0098772
Participates
as a candidate of
ALKAL2:(ALKAL1) [extracellular region] (Rattus norvegicus)
as a member of
ALKAL1,2 [extracellular region] (Rattus norvegicus)
Inferred From
ALKAL1 [extracellular region]
(Homo sapiens)
Cross References
RefSeq
NP_001289072.1
Ensembl
ENSRNOG00000048703
,
ENSRNOP00000066096
,
ENSRNOT00000073694
RGD
1583530
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