TIM9:TIM10 binds hydrophobic proteins

Stable Identifier
R-SCE-1252259
Type
Reaction [binding]
Species
Saccharomyces cerevisiae
Compartment
mitochondrial intermembrane space
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
TIM9:TIM10 binds hydrophobic proteins
The TIM9:TIM10 complex chaperones hydrophobic membrane proteins in the intermembrane space until their insertion into the inner or outer membrane (Koehler et al. 1998, Leuenberger et al. 1999, Luciano et al. 2001, Truscott et al. 2002, Vasiljev et al. 2004, Wiedemann et al. 2004, Davis et al. 2007, Baker et al. 2009, Hasson et al. 2010). Substrates of the TIM9:TIM10 complex include AAC (Koehler et al. 1998, Leuenberger et al. 1999, Luciano et al. 2001, Truscott et al. 2002, Vasiljev et al. 2004, Baker et al. 2009, Hasson et al. 2010), TIM17 (Leuenberger et al. 1999), TOM40 (Wiedemann et al. 2004), TIM23 (Davis et al. 2007), TIM22 (Hasson et al. 2010), and Tafazzin (Hasson et al. 2010).
Literature References
PubMed ID Title Journal Year
20457929 Substrate specificity of the TIM22 mitochondrial import pathway revealed with small molecule inhibitor of protein translocation

Dabir, DV, Hasson, SA, Walker, SS, Koehler, CM, Glavin, JD, Damoiseaux, R

Proc Natl Acad Sci U S A 2010
14978039 Biogenesis of the protein import channel Tom40 of the mitochondrial outer membrane: intermembrane space components are involved in an early stage of the assembly pathway

Pfanner, N, Wiedemann, N, Guiard, B, Pfannschmidt, S, Meisinger, C, Truscott, KN

J Biol Chem 2004
14668492 Reconstituted TOM core complex and Tim9/Tim10 complex of mitochondria are sufficient for translocation of the ADP/ATP carrier across membranes

Panneels, V, Ahting, U, Go, NE, Neupert, W, Habib, SJ, Rapaport, D, Nussberger, S, Kozany, C, Prokisch, H, Nargang, FE, Vasiljev, A, Sinning, I

Mol Biol Cell 2004
12391147 Mitochondrial import of the ADP/ATP carrier: the essential TIM complex of the intermembrane space is required for precursor release from the TOM complex

Pfanner, N, Müller, H, Rehling, P, Wiedemann, N, Guiard, B, Meisinger, C, Truscott, KN

Mol Cell Biol 2002
17122363 The Tim9p/10p and Tim8p/13p complexes bind to specific sites on Tim23p during mitochondrial protein import

Davis, AJ, Jensen, RE, Johnson, AE, Alder, NN

Mol Biol Cell 2007
10469659 Different import pathways through the mitochondrial intermembrane space for inner membrane proteins

Schatz, G, Leuenberger, D, Bally, NA, Koehler, CM

EMBO J 1999
9822593 Tim9p, an essential partner subunit of Tim10p for the import of mitochondrial carrier proteins

Schatz, G, Tokatlidis, K, Jarosch, E, Dolfini, L, Oppliger, W, Junne, T, Koehler, CM, Merchant, S, Schmid, K

EMBO J 1998
19037098 Structural and functional requirements for activity of the Tim9-Tim10 complex in mitochondrial protein import

Palmer, CS, Gulbis, JM, Baker, MJ, Ryan, MT, Frazier, AE, Guiard, B, Stroud, DA, Webb, CT, Chacinska, A

Mol Biol Cell 2009
11483513 Functional reconstitution of the import of the yeast ADP/ATP carrier mediated by the TIM10 complex

Dyall, SD, Luciano, P, Tokatlidis, K, Vergnolle, MA, Robinson, DR, Vial, S

EMBO J 2001
Participants
Input
Output
Orthologous Events
TIMM9:TIMM10 binds hydrophobic proteins (Homo sapiens)
Authored
May, B  (2011-04-22)
Reviewed
Endo, T  (2012-02-12)
D'Eustachio, P  (2011-11-02)
Created
May, B  (2011-04-27)
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