The alpha subunit (MAS2, Alpha-MPP) of the mitochondrial processing peptidase (MPP) binds presequences of mitochondrial precursors and the beta subunit (MAS1, Beta-MPP) cleaves the presequence (Yang et al. 1991, Geli 1993, Luciano et al. 1997, Luciano et al. 1998, Taylor et al. 2001, Dvorakova-Hola et al. 2010). After cleavage, proteins destined for the matrix are drawn into the matrix by ATP-dependent interaction with mtHSP70 (SSC1) of the PAM complex.
Taylor, AB, Smith, BS, Kitada, S, Kojima, K, Miyaura, H, Otwinowski, Z, Ito, A, Deisenhofer, J
Yang, MJ, Geli, V, Oppliger, W, Suda, K, James, P, Schatz, G
Géli, V
Luciano, P, Tokatlidis, K, Chambre, I, Germanique, JC, Géli, V
Dvoráková-Holá, K, Matusková, A, Kubala, M, Otyepka, M, Kucera, T, Vecer, J, Herman, P, Parkhomenko, N, Kutejova, E, Janata, J
Luciano, P, Geoffroy, S, Brandt, A, Hernandez, JF, Géli, V
Milisav, I, Moro, F, Neupert, W, Brunner, M
© 2021 Reactome