Reactome | MPP hydrolyzes presequence of matrix precursors

MPP hydrolyzes presequence of matrix precursors

Stable Identifier

R-SCE-1268017

Type

Reaction [transition]

Species

Saccharomyces cerevisiae

Compartment

mitochondrial matrix, mitochondrial inner membrane

ReviewStatus

5/5

General

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SVG | | PPTX | SBGN

MPP hydrolyzes presequence of matrix precursors

The alpha subunit (MAS2, Alpha-MPP) of the mitochondrial processing peptidase (MPP) binds presequences of mitochondrial precursors and the beta subunit (MAS1, Beta-MPP) cleaves the presequence (Yang et al. 1991, Geli 1993, Luciano et al. 1997, Luciano et al. 1998, Taylor et al. 2001, Dvorakova-Hola et al. 2010). After cleavage, proteins destined for the matrix are drawn into the matrix by ATP-dependent interaction with mtHSP70 (SSC1) of the PAM complex.

Literature References

PubMed ID	Title	Journal	Year
2007593	The MAS-encoded processing protease of yeast mitochondria. Interaction of the purified enzyme with signal peptides and a purified precursor protein Schatz, G, James, P, Oppliger, W, Geli, V, Yang, MJ, Suda, K	J Biol Chem	1991
11470436	Crystal structures of mitochondrial processing peptidase reveal the mode for specific cleavage of import signal sequences Deisenhofer, J, Otwinowski, Z, Kitada, S, Taylor, AB, Ito, A, Miyaura, H, Kojima, K, Smith, BS	Structure	2001
8327505	Functional reconstitution in Escherichia coli of the yeast mitochondrial matrix peptidase from its two inactive subunits Géli, V	Proc Natl Acad Sci U S A	1993
9654444	The mitochondrial processing peptidase behaves as a zinc-metallopeptidase Géli, V, Luciano, P, Tokatlidis, K, Germanique, JC, Chambre, I	J Mol Biol	1998
20053354	Glycine-rich loop of mitochondrial processing peptidase alpha-subunit is responsible for substrate recognition by a mechanism analogous to mitochondrial receptor Tom20 Janata, J, Kubala, M, Vecer, J, Otyepka, M, Parkhomenko, N, Kucera, T, Dvoráková-Holá, K, Herman, P, Matusková, A, Kutejova, E	J Mol Biol	2010
9299349	Functional cooperation of the mitochondrial processing peptidase subunits Géli, V, Luciano, P, Geoffroy, S, Hernandez, JF, Brandt, A	J Mol Biol	1997
11344168	Modular structure of the TIM23 preprotein translocase of mitochondria Moro, F, Neupert, W, Milisav, I, Brunner, M	J Biol Chem	2001