Reactome | STO1 [cytosol]

STO1 [cytosol]

Stable Identifier

R-SCE-162459

Type

Protein [EntityWithAccessionedSequence]

Species

Saccharomyces cerevisiae

Compartment

cytosol

Synonyms

NCBP1, P34160

Locations in the PathwayBrowser

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Metabolism of RNA (Saccharomyces cerevisiae)

- Nonsense-Mediated Decay (NMD) (Saccharomyces cerevisiae)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Saccharomyces cerevisiae)
    - Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex (Saccharomyces cerevisiae)
      - Cap Binding Complex (CBC) [cytosol] (Saccharomyces cerevisiae)
        
        STO1 [cytosol] (Saccharomyces cerevisiae)
      - mRNA Cleaved by SMG6 [cytosol] (Saccharomyces cerevisiae)
        
        Cap Binding Complex (CBC) [cytosol] (Saccharomyces cerevisiae)
        
        STO1 [cytosol] (Saccharomyces cerevisiae)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Saccharomyces cerevisiae)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Saccharomyces cerevisiae)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        Cap Binding Complex (CBC) [cytosol] (Saccharomyces cerevisiae)
        
        STO1 [cytosol] (Saccharomyces cerevisiae)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Saccharomyces cerevisiae)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        Cap Binding Complex (CBC) [cytosol] (Saccharomyces cerevisiae)
        
        STO1 [cytosol] (Saccharomyces cerevisiae)
    - SMG6 hydrolyzes mRNA with premature termination codon (Saccharomyces cerevisiae)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Saccharomyces cerevisiae)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        Cap Binding Complex (CBC) [cytosol] (Saccharomyces cerevisiae)
        
        STO1 [cytosol] (Saccharomyces cerevisiae)
      - mRNA Cleaved by SMG6 [cytosol] (Saccharomyces cerevisiae)
        
        Cap Binding Complex (CBC) [cytosol] (Saccharomyces cerevisiae)
        
        STO1 [cytosol] (Saccharomyces cerevisiae)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Saccharomyces cerevisiae)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Saccharomyces cerevisiae)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        mRNA Complex with a Premature Termination Codon Not Preceding an Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        Cap Binding Complex (CBC) [cytosol] (Saccharomyces cerevisiae)
        
        STO1 [cytosol] (Saccharomyces cerevisiae)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Saccharomyces cerevisiae)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        mRNA Complex with a Premature Termination Codon Not Preceding an Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        Cap Binding Complex (CBC) [cytosol] (Saccharomyces cerevisiae)
        
        STO1 [cytosol] (Saccharomyces cerevisiae)

External Reference Information

External Reference

UniProt:P34160

Gene Names

STO1

Reference Genes

BioGPS Gene:855155 STO1

ENSEMBL:YMR125W

KEGG Gene (Saccharomyces cerevisiae (strain YJM789)):YMR125W STO1

Monarch:855155 STO1

NCBI Gene:855155 STO1

SGD:YMR125W

Reference Transcript

RefSeq:NM_001182626.1 STO1

Other Identifiers

1771887_at

855155

9524_at

GO:0000184

GO:0000243

GO:0000339

GO:0000398

GO:0000956

GO:0003674

GO:0003723

GO:0003729

GO:0005515

GO:0005575

GO:0005634

GO:0005737

GO:0005844

GO:0005845

GO:0005846

GO:0006366

GO:0006370

GO:0006397

GO:0006401

GO:0006406

GO:0006970

GO:0008150

GO:0008380

GO:0015931

GO:0016070

GO:0031053

GO:0031124

GO:0042789

GO:0045292

GO:0048471

GO:0051028

GO:0051169

Participates

as a component of

Cap Binding Complex (CBC) [cytosol] (Saccharomyces cerevisiae)

Other forms of this molecule

STO1 [nucleoplasm]

Inferred From

NCBP1 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_013844.2

PRO

P34160

PDB

3UKY, 6N7P

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q08920	2	CBC2 [cytosol] (R-SCE-162458) CBC2 [nucleoplasm] (R-SCE-51463)	0.818	25
UniProt:Q02821	2	SRP1 [cytosol] (R-SCE-180612) SRP1 [cytosol] (R-SCE-9734672)	0.69	12
UniProt:P36036 YRA2			0.564	6
UniProt:Q05900 RU1C			0.564	5
UniProt:P10592	8	SSA2 [cytosol] (R-SCE-264476) SSA2 [nucleoplasm] (R-SCE-5082380) SSA2 [ficolin-1-rich granule lumen] (R-SCE-6801494) SSA2 [extracellular region] (R-SCE-6805936) SSA2 [secretory granule lumen] (R-SCE-6801530) SSA2 [nucleoplasm] (R-SCE-912480-3) SSA2 [cytosol] (R-SCE-3371408-3) SSA2 [nucleoplasm] (R-SCE-8932217)	0.527	2
UniProt:P53617	3	NRD1 [cytosol] (R-SCE-9715142) phospho-NRD1 [nucleoplasm] (R-SCE-8849461) NRD1 [nucleoplasm] (R-SCE-3900138)	0.527	3
UniProt:P07260	1	CDC33 [cytosol] (R-SCE-72578)	0.527	2