Reactome | NCBP1 [cytosol]

NCBP1 [cytosol]

Stable Identifier

R-SCE-162459

Type

Protein [EntityWithAccessionedSequence]

Species

Saccharomyces cerevisiae

Compartment

cytosol

Synonyms

P34160

Locations in the PathwayBrowser

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Metabolism of RNA (Saccharomyces cerevisiae)

- Nonsense-Mediated Decay (NMD) (Saccharomyces cerevisiae)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Saccharomyces cerevisiae)
    - Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex (Saccharomyces cerevisiae)
      - Cap Binding Complex (CBC) [cytosol] (Saccharomyces cerevisiae)
        
        NCBP1 [cytosol] (Saccharomyces cerevisiae)
      - mRNA Cleaved by SMG6 [cytosol] (Saccharomyces cerevisiae)
        
        Cap Binding Complex (CBC) [cytosol] (Saccharomyces cerevisiae)
        
        NCBP1 [cytosol] (Saccharomyces cerevisiae)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Saccharomyces cerevisiae)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Saccharomyces cerevisiae)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        Cap Binding Complex (CBC) [cytosol] (Saccharomyces cerevisiae)
        
        NCBP1 [cytosol] (Saccharomyces cerevisiae)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Saccharomyces cerevisiae)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        Cap Binding Complex (CBC) [cytosol] (Saccharomyces cerevisiae)
        
        NCBP1 [cytosol] (Saccharomyces cerevisiae)
    - SMG6 hydrolyzes mRNA with premature termination codon (Saccharomyces cerevisiae)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Saccharomyces cerevisiae)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        Cap Binding Complex (CBC) [cytosol] (Saccharomyces cerevisiae)
        
        NCBP1 [cytosol] (Saccharomyces cerevisiae)
      - mRNA Cleaved by SMG6 [cytosol] (Saccharomyces cerevisiae)
        
        Cap Binding Complex (CBC) [cytosol] (Saccharomyces cerevisiae)
        
        NCBP1 [cytosol] (Saccharomyces cerevisiae)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Saccharomyces cerevisiae)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Saccharomyces cerevisiae)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        mRNA Complex with a Premature Termination Codon Not Preceding an Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        Cap Binding Complex (CBC) [cytosol] (Saccharomyces cerevisiae)
        
        NCBP1 [cytosol] (Saccharomyces cerevisiae)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Saccharomyces cerevisiae)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        mRNA Complex with a Premature Termination Codon Not Preceding an Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        Cap Binding Complex (CBC) [cytosol] (Saccharomyces cerevisiae)
        
        NCBP1 [cytosol] (Saccharomyces cerevisiae)

External Reference Information

External Reference

UniProt:P34160

Reference Genes

BioGPS Gene:855155

dbSNP Gene:855155

ENSEMBL:YMR125W

KEGG Gene (Saccharomyces cerevisiae (strain RM11-1a)):YMR125W

Monarch:855155

NCBI Gene:855155

SGD:YMR125W

Reference Transcript

RefSeq:NM_001182626.1

Other Identifiers

1771887_at

3UKY

4932.YMR125W

9524_at

BAA01076.1

CAA88550.1

CAA89274.1

DAA10022.1

EntrezGene:855155

EntrezGene:STO1

GO:0000184

GO:0000243

GO:0000339

GO:0000398

GO:0003674

GO:0003723

GO:0003729

GO:0005515

GO:0005575

GO:0005634

GO:0005737

GO:0005844

GO:0005845

GO:0005846

GO:0006370

GO:0006397

GO:0006401

GO:0006406

GO:0006970

GO:0008150

GO:0008380

GO:0015931

GO:0016070

GO:0031053

GO:0045292

GO:0048471

GO:0051028

GO:0051169

IPR003890

IPR015172

IPR015174

IPR016021

IPR016024

IPR027159

L07650

L27744

NM_001182626.1

NP_013844.2

PF02854

PF09088

PF09090

SM00543

UPI000012B2FE

YMR125W

YMR125W_mRNA

Participant Of

hasComponent

Cap Binding Complex (CBC) [cytosol]

Other forms of this molecule

NCBP1 [nucleoplasm]

Inferred From

NCBP1 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_013844.2

PRO

P34160

PDB

3UKY

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q08920	2	NCBP2 [nucleoplasm] (R-SCE-51463) NCBP2 [cytosol] (R-SCE-162458)	0.818	25
UniProt:Q02821	2	KPNA2 [cytosol] (R-SCE-205976) KPNA1 [cytosol] (R-SCE-180612)	0.69	12
UniProt:P36036 YRA2			0.564	6
UniProt:Q05900 RU1C			0.564	5
UniProt:P10592	23	HSPA6 [ficolin-1-rich granule lumen] (R-SCE-6801512-3) HSPA8 [cytosol] (R-SCE-264476-3) HSPA1A [ficolin-1-rich granule lumen] (R-SCE-6801496-3) HSPA8 [ficolin-1-rich granule lumen] (R-SCE-6801494-3) HSPA1A [extracellular region] (R-SCE-6805872-3) HSPA6 [extracellular region] (R-SCE-6806500-3) HSPA8 [extracellular region] (R-SCE-6805936-3) HSPA8 [secretory granule lumen] (R-SCE-6801530-3) HSPA6 [secretory granule lumen] (R-SCE-6801472-3) HSPA8 [nucleoplasm] (R-SCE-5082380-3) HSPA2 [nucleoplasm] (R-SCE-912480-3) HSPA1L [nucleoplasm] (R-SCE-5082367-3) HSPA1A [nucleoplasm] (R-SCE-6792605-3) HSPA6 [nucleoplasm] (R-SCE-5252088-3) HSPA13 [nucleoplasm] (R-SCE-5252009-3) HSPA7 [nucleoplasm] (R-SCE-5252047-3) HSPA1L [cytosol] (R-SCE-3371410-3) HSPA2 [cytosol] (R-SCE-3371408-3) HSPA13 [cytosol] (R-SCE-5251981-3) HSPA6 [cytosol] (R-SCE-3371521-3) HSPA7 [cytosol] (R-SCE-5251954-3) HSPA1A [cytosol] (R-SCE-6792602-3) Me3K561-HSPA8 [nucleoplasm] (R-SCE-8932217-3)	0.527	2
UniProt:P53617	2	SFPQ [nucleoplasm] (R-SCE-3900138) phospho-p-Y-SFPQ [nucleoplasm] (R-SCE-8849461)	0.527	3
UniProt:P07260	1	EIF4E [cytosol] (R-SCE-72578)	0.527	2