Reactome | phospho-p-S1108,S1148,S1192-EIF4G1 [cytosol]

phospho-p-S1108,S1148,S1192-EIF4G1 [cytosol]

Stable Identifier

R-SCE-165762

Type

Protein [EntityWithAccessionedSequence]

Species

Saccharomyces cerevisiae

Compartment

cytosol

Synonyms

P39935

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P39935

Reference Genes

BioGPS Gene:853071

ENSEMBL:YGR162W

KEGG Gene (Saccharomyces cerevisiae (strain RM11-1a)):YGR162W

Monarch:853071

NCBI Gene:853071

SGD:YGR162W

Reference Transcript

RefSeq:NM_001181291.3

Other Identifiers

1RF8

2VSO

2VSX

4932.YGR162W

AAA02757.1

AAT92992.1

CAA97184.1

DAA08257.1

EntrezGene:853071

GO:0000932

GO:0003674

GO:0003723

GO:0003743

GO:0005515

GO:0005575

GO:0005737

GO:0006413

GO:0006417

GO:0008135

GO:0008150

GO:0010494

GO:0010942

GO:0016281

GO:0023052

GO:0032268

GO:0034063

GO:0042221

GO:0042273

GO:0070925

GO:1900103

IPR003890

IPR016021

IPR016024

IPR022745

IPR036211

NM_001181291.3

NP_011678.3

PF02854

PF12152

SM00543

UPI0000052E5B

YGR162W

YGR162W_mRNA

Participant Of

output

Phosphorylation and activation of eIF4G by activated S6K1

Other forms of this molecule

EIF4G1 [cytosol]

Inferred From

p-S1108,S1148,S1192-EIF4G1 [cytosol] (Homo sapiens)

Modified Residues

Name

O-phospho-L-serine at 1108 (in Homo sapiens)

Coordinate

1108

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 1148 (in Homo sapiens)

Coordinate

1148

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 1192 (in Homo sapiens)

Coordinate

1192

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

NP_011678.3

PRO

P39935

PDB

2VSX, 1RF8, 2VSO

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P07260	1	EIF4E [cytosol] (R-SCE-72578)	0.957	29
UniProt:P10081	2	EIF4A1 [cytosol] (R-SCE-72573) EIF4A2 [cytosol] (R-SCE-72575)	0.929	18
UniProt:P04147	1	PABPC1 [cytosol] (R-SCE-156803)	0.872	19
UniProt:P33322	1	DKC1 [nucleoplasm] (R-SCE-163102)	0.592	4
UniProt:P40561	1	PABPN1 [nucleoplasm] (R-SCE-72008-2)	0.592	3
UniProt:P39935	2	EIF4G1 [cytosol] (R-SCE-72584) phospho-p-S1108,S1148,S1192-EIF4G1 [cytosol] (R-SCE-165762)	0.573	2
UniProt:P06634	3	DDX3X [extracellular region] (R-SCE-6806507) DDX3X [secretory granule lumen] (R-SCE-6801275) DDX3X [ficolin-1-rich granule lumen] (R-SCE-6801273)	0.564	2
UniProt:P38788	2	HSPA14 [nucleoplasm] (R-SCE-5252082) HSPA14 [cytosol] (R-SCE-5251948)	0.527	2
UniProt:P10591	23	HSPA8 [nucleoplasm] (R-SCE-5082380-2) HSPA8 [cytosol] (R-SCE-264476-2) HSPA6 [ficolin-1-rich granule lumen] (R-SCE-6801512-2) HSPA1A [ficolin-1-rich granule lumen] (R-SCE-6801496-2) HSPA8 [ficolin-1-rich granule lumen] (R-SCE-6801494-2) HSPA1A [extracellular region] (R-SCE-6805872-2) HSPA6 [extracellular region] (R-SCE-6806500-2) HSPA8 [extracellular region] (R-SCE-6805936-2) HSPA8 [secretory granule lumen] (R-SCE-6801530-2) HSPA6 [secretory granule lumen] (R-SCE-6801472-2) HSPA2 [nucleoplasm] (R-SCE-912480-2) HSPA1L [nucleoplasm] (R-SCE-5082367-2) HSPA1A [nucleoplasm] (R-SCE-6792605-2) HSPA6 [nucleoplasm] (R-SCE-5252088-2) HSPA13 [nucleoplasm] (R-SCE-5252009-2) HSPA7 [nucleoplasm] (R-SCE-5252047-2) HSPA1L [cytosol] (R-SCE-3371410-2) HSPA2 [cytosol] (R-SCE-3371408-2) HSPA13 [cytosol] (R-SCE-5251981-2) HSPA6 [cytosol] (R-SCE-3371521-2) HSPA7 [cytosol] (R-SCE-5251954-2) HSPA1A [cytosol] (R-SCE-6792602-2) Me3K561-HSPA8 [nucleoplasm] (R-SCE-8932217-2)	0.527	2
UniProt:P10592	23	HSPA8 [nucleoplasm] (R-SCE-5082380-3) HSPA8 [cytosol] (R-SCE-264476-3) HSPA6 [ficolin-1-rich granule lumen] (R-SCE-6801512-3) HSPA1A [ficolin-1-rich granule lumen] (R-SCE-6801496-3) HSPA8 [ficolin-1-rich granule lumen] (R-SCE-6801494-3) HSPA1A [extracellular region] (R-SCE-6805872-3) HSPA6 [extracellular region] (R-SCE-6806500-3) HSPA8 [extracellular region] (R-SCE-6805936-3) HSPA8 [secretory granule lumen] (R-SCE-6801530-3) HSPA6 [secretory granule lumen] (R-SCE-6801472-3) HSPA2 [nucleoplasm] (R-SCE-912480-3) HSPA1L [nucleoplasm] (R-SCE-5082367-3) HSPA1A [nucleoplasm] (R-SCE-6792605-3) HSPA6 [nucleoplasm] (R-SCE-5252088-3) HSPA13 [nucleoplasm] (R-SCE-5252009-3) HSPA7 [nucleoplasm] (R-SCE-5252047-3) HSPA1L [cytosol] (R-SCE-3371410-3) HSPA2 [cytosol] (R-SCE-3371408-3) HSPA13 [cytosol] (R-SCE-5251981-3) HSPA6 [cytosol] (R-SCE-3371521-3) HSPA7 [cytosol] (R-SCE-5251954-3) HSPA1A [cytosol] (R-SCE-6792602-3) Me3K561-HSPA8 [nucleoplasm] (R-SCE-8932217-3)	0.527	2
UniProt:P11484	23	HSPA8 [nucleoplasm] (R-SCE-5082380-4) HSPA8 [cytosol] (R-SCE-264476-4) HSPA6 [ficolin-1-rich granule lumen] (R-SCE-6801512-4) HSPA1A [ficolin-1-rich granule lumen] (R-SCE-6801496-4) HSPA8 [ficolin-1-rich granule lumen] (R-SCE-6801494-4) HSPA1A [extracellular region] (R-SCE-6805872-4) HSPA6 [extracellular region] (R-SCE-6806500-4) HSPA8 [extracellular region] (R-SCE-6805936-4) HSPA8 [secretory granule lumen] (R-SCE-6801530-4) HSPA6 [secretory granule lumen] (R-SCE-6801472-4) HSPA2 [nucleoplasm] (R-SCE-912480-4) HSPA1L [nucleoplasm] (R-SCE-5082367-4) HSPA1A [nucleoplasm] (R-SCE-6792605-4) HSPA6 [nucleoplasm] (R-SCE-5252088-4) HSPA13 [nucleoplasm] (R-SCE-5252009-4) HSPA7 [nucleoplasm] (R-SCE-5252047-4) HSPA1L [cytosol] (R-SCE-3371410-4) HSPA2 [cytosol] (R-SCE-3371408-4) HSPA13 [cytosol] (R-SCE-5251981-4) HSPA6 [cytosol] (R-SCE-3371521-4) HSPA7 [cytosol] (R-SCE-5251954-4) HSPA1A [cytosol] (R-SCE-6792602-4) Me3K561-HSPA8 [nucleoplasm] (R-SCE-8932217-4)	0.527	2