Reactome | phospho-SCH9 [cytosol]

phospho-SCH9 [cytosol]

Stable Identifier

R-SCE-166800

Type

Protein [EntityWithAccessionedSequence]

Species

Saccharomyces cerevisiae

Compartment

cytosol

Synonyms

p-T309,S474-AKT2, P11792

Locations in the PathwayBrowser

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Signal Transduction (Saccharomyces cerevisiae)

- Intracellular signaling by second messengers (Saccharomyces cerevisiae)
  - PIP3 activates AKT signaling (Saccharomyces cerevisiae)
    - PDPK1 phosphorylates AKT at T308 (Saccharomyces cerevisiae)
      - p-T,p-S-AKT [cytosol] (Saccharomyces cerevisiae)
        
        Homologues of p-T309,S474-AKT2 [cytosol] (Saccharomyces cerevisiae)
        
        phospho-SCH9 [cytosol] (Saccharomyces cerevisiae)
- Signaling by Receptor Tyrosine Kinases (Saccharomyces cerevisiae)
  - Signaling by ERBB2 (Saccharomyces cerevisiae)
    - Downregulation of ERBB2 signaling (Saccharomyces cerevisiae)
      - Downregulation of ERBB2:ERBB3 signaling (Saccharomyces cerevisiae)
        
        Phosphorylation of USP8 by P-AKT (Saccharomyces cerevisiae)
        
        p-T,p-S-AKT [cytosol] (Saccharomyces cerevisiae)
        
        Homologues of p-T309,S474-AKT2 [cytosol] (Saccharomyces cerevisiae)
        
        phospho-SCH9 [cytosol] (Saccharomyces cerevisiae)
  - Signaling by Insulin receptor (Saccharomyces cerevisiae)
    - Insulin receptor signalling cascade (Saccharomyces cerevisiae)
      - IRS-mediated signalling (Saccharomyces cerevisiae)
        
        PI3K Cascade (Saccharomyces cerevisiae)
        
        Activation of AKT2 (Saccharomyces cerevisiae)
        
        PDPK1 phosphorylates AKT2 (Saccharomyces cerevisiae)
        
        p-T309,S474-AKT2:PIP3 [plasma membrane] (Saccharomyces cerevisiae)
        
        Homologues of p-T309,S474-AKT2 [cytosol] (Saccharomyces cerevisiae)
        
        phospho-SCH9 [cytosol] (Saccharomyces cerevisiae)
  - Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Saccharomyces cerevisiae)
    - IGF1R signaling cascade (Saccharomyces cerevisiae)
      - IRS-related events triggered by IGF1R (Saccharomyces cerevisiae)
        
        IRS-mediated signalling (Saccharomyces cerevisiae)
        
        PI3K Cascade (Saccharomyces cerevisiae)
        
        Activation of AKT2 (Saccharomyces cerevisiae)
        
        PDPK1 phosphorylates AKT2 (Saccharomyces cerevisiae)
        
        p-T309,S474-AKT2:PIP3 [plasma membrane] (Saccharomyces cerevisiae)
        
        Homologues of p-T309,S474-AKT2 [cytosol] (Saccharomyces cerevisiae)
        
        phospho-SCH9 [cytosol] (Saccharomyces cerevisiae)
  - Signaling by VEGF (Saccharomyces cerevisiae)
    - VEGFA-VEGFR2 Pathway (Saccharomyces cerevisiae)
      - VEGFR2 mediated vascular permeability (Saccharomyces cerevisiae)
        
        PDPK1 phosphorylates AKT at T308 (Saccharomyces cerevisiae)
        
        p-T,p-S-AKT [cytosol] (Saccharomyces cerevisiae)
        
        Homologues of p-T309,S474-AKT2 [cytosol] (Saccharomyces cerevisiae)
        
        phospho-SCH9 [cytosol] (Saccharomyces cerevisiae)

External Reference Information

External Reference

UniProt:P11792

Gene Names

SCH9

Reference Genes

BioGPS Gene:856612 SCH9

ENSEMBL:YHR205W

KEGG Gene (Saccharomyces cerevisiae):YHR205W SCH9

Monarch:856612 SCH9

NCBI Gene:856612 SCH9

SGD:YHR205W

Reference Transcript

RefSeq:NM_001179336.1 SCH9

Other Identifiers

1776699_at

4318_at

856612

GO:0000329

GO:0001302

GO:0001324

GO:0003674

GO:0004672

GO:0004674

GO:0005524

GO:0005575

GO:0005634

GO:0005737

GO:0005773

GO:0006360

GO:0006366

GO:0006383

GO:0006468

GO:0006629

GO:0006970

GO:0006979

GO:0008150

GO:0016020

GO:0016301

GO:0016740

GO:0018105

GO:0018193

GO:0023052

GO:0032880

GO:0035556

GO:0042221

GO:0043167

GO:0043619

GO:0045943

GO:0045945

GO:0047484

GO:0060963

GO:0090153

Participant Of

hasMember

Homologues of p-T309,S474-AKT2 [cytosol]

Other forms of this molecule

phospho-SCH9 [nucleoplasm]

phospho-SCH9 [plasma membrane]

phospho-SCH9 [cytosol]

SCH9 [cytosol]

phospho-SCH9 [cytosol]

SCH9 [cytosol]

phospho-SCH9 [cytosol]

phospho-SCH9 [plasma membrane]

SCH9 [plasma membrane]

SCH9 [cytosol]

phospho-SCH9 [nucleoplasm]

Inferred From

p-T309,S474-AKT2 [cytosol] (Homo sapiens)

Modified Residues

Name

O-phospho-L-threonine at 309 (in Homo sapiens)

Coordinate

309

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Name

O-phospho-L-serine at 474 (in Homo sapiens)

Coordinate

474

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

NP_012075.1

IntEnz

2.7.11.1

PRO

P11792

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