Reactome | HTB2 [nucleoplasm]

HTB2 [nucleoplasm]

Stable Identifier

R-SCE-181916-2

Type

Protein [EntityWithAccessionedSequence]

Species

Saccharomyces cerevisiae

Compartment

nucleoplasm

Synonyms

HIST1H2BA, P02294

Locations in the PathwayBrowser

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Cell Cycle (Saccharomyces cerevisiae)

- Cell Cycle, Mitotic (Saccharomyces cerevisiae)
  - M Phase (Saccharomyces cerevisiae)
    - Mitotic Prophase (Saccharomyces cerevisiae)
      - Condensation of Prophase Chromosomes (Saccharomyces cerevisiae)
        
        PHF8 demethylates histone H4K20me1 (Saccharomyces cerevisiae)
        
        PHF8:Nucleosome with H3K4me2/3 [nucleoplasm] (Saccharomyces cerevisiae)
        
        Nucleosome with H3K4me2/3 [nucleoplasm] (Saccharomyces cerevisiae)
        
        Histone H2B [nucleoplasm] (Saccharomyces cerevisiae)
        
        Homologues of HIST1H2BA [nucleoplasm] (Saccharomyces cerevisiae)
        
        HTB2 [nucleoplasm] (Saccharomyces cerevisiae)
        
        PHF8:Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Saccharomyces cerevisiae)
        
        Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Saccharomyces cerevisiae)
        
        Histone H2B [nucleoplasm] (Saccharomyces cerevisiae)
        
        Homologues of HIST1H2BA [nucleoplasm] (Saccharomyces cerevisiae)
        
        HTB2 [nucleoplasm] (Saccharomyces cerevisiae)

Cellular responses to external stimuli (Saccharomyces cerevisiae)

- Cellular responses to stress (Saccharomyces cerevisiae)
  - Cellular Senescence (Saccharomyces cerevisiae)
    - Oxidative Stress Induced Senescence (Saccharomyces cerevisiae)
      - KDM6B demethylates H3K27me3 on p16INK4A promoter (Saccharomyces cerevisiae)
        
        CDKN2A Gene:H3K27Me3-Nucleosome [nucleoplasm] (Saccharomyces cerevisiae)
        
        Nucleosome with H3K27me3 [nucleoplasm] (Saccharomyces cerevisiae)
        
        Histone H2B [nucleoplasm] (Saccharomyces cerevisiae)
        
        Homologues of HIST1H2BA [nucleoplasm] (Saccharomyces cerevisiae)
        
        HTB2 [nucleoplasm] (Saccharomyces cerevisiae)
        
        CDKN2A Gene:Nucleosome [nucleoplasm] (Saccharomyces cerevisiae)
        
        Nucleosome [nucleoplasm] (Saccharomyces cerevisiae)
        
        Histone H2B [nucleoplasm] (Saccharomyces cerevisiae)
        
        Homologues of HIST1H2BA [nucleoplasm] (Saccharomyces cerevisiae)
        
        HTB2 [nucleoplasm] (Saccharomyces cerevisiae)

Metabolism of proteins (Saccharomyces cerevisiae)

- Post-translational protein modification (Saccharomyces cerevisiae)
  - Deubiquitination (Saccharomyces cerevisiae)
    - Ub-specific processing proteases (Saccharomyces cerevisiae)
      - USP3,SAGA deubiquitinate Histone H2A,H2B (Saccharomyces cerevisiae)
        
        USP3,SAGA:Histone H2A,Histone H2B [nucleoplasm] (Saccharomyces cerevisiae)
        
        Histone H2B [nucleoplasm] (Saccharomyces cerevisiae)
        
        Histone HIST1H2B [nucleoplasm] (Saccharomyces cerevisiae)
        
        Homologues of HIST1H2BA [nucleoplasm] (Saccharomyces cerevisiae)
        
        HTB2 [nucleoplasm] (Saccharomyces cerevisiae)

Signal Transduction (Saccharomyces cerevisiae)

- Signaling by Nuclear Receptors (Saccharomyces cerevisiae)
  - ESR-mediated signaling (Saccharomyces cerevisiae)
    - Estrogen-dependent gene expression (Saccharomyces cerevisiae)
      - FOXA1 and GATA3 bind to CCND1 promoter (Saccharomyces cerevisiae)
        
        CCND1 gene:H3K4me2 nucleosome:FOXA1:GATA3 [nucleoplasm] (Saccharomyces cerevisiae)
        
        Nucleosome with H3K4me2 [nucleoplasm] (Saccharomyces cerevisiae)
        
        Histone H2B [nucleoplasm] (Saccharomyces cerevisiae)
        
        Homologues of HIST1H2BA [nucleoplasm] (Saccharomyces cerevisiae)
        
        HTB2 [nucleoplasm] (Saccharomyces cerevisiae)
        
        CCND1 gene:H3K4me2 nucleosome:YY1:HDAC1 [nucleoplasm] (Saccharomyces cerevisiae)
        
        Nucleosome with H3K4me2 [nucleoplasm] (Saccharomyces cerevisiae)
        
        Histone H2B [nucleoplasm] (Saccharomyces cerevisiae)
        
        Homologues of HIST1H2BA [nucleoplasm] (Saccharomyces cerevisiae)
        
        HTB2 [nucleoplasm] (Saccharomyces cerevisiae)

External Reference Information

External Reference

UniProt:P02294

Gene Names

HTB2

Reference Genes

BioGPS Gene:852284 HTB2

ENSEMBL:YBL002W

KEGG Gene (Saccharomyces cerevisiae (strain RM11-1a)):YBL002W HTB2

Monarch:852284 HTB2

NCBI Gene:852284 HTB2

SGD:YBL002W

Reference Transcript

RefSeq:NM_001178242.1 HTB2

Other Identifiers

1777846_at

7359_at

852284

GO:0000786

GO:0000788

GO:0003674

GO:0003677

GO:0005575

GO:0005634

GO:0005694

GO:0006325

GO:0006333

GO:0008150

GO:0031298

GO:0046982

Participates

as a member of

Homologues of HIST1H2BA [nucleoplasm] (Saccharomyces cerevisiae)

Other forms of this molecule

HTB2 [nucleoplasm]

Inferred From

HIST1H2BA [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_009553.1

PRO

P02294

PDB

2FSB, 6QLD, 4JJN, 1ID3

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P02309	14	HHF2 [nucleoplasm] (R-SCE-212078) HHF2 [nucleoplasm] (R-SCE-4570518) HHF2 [nucleoplasm] (R-SCE-4568744) HHF2 [nucleoplasm] (R-SCE-4568748) HHF2 [nucleoplasm] (R-SCE-427469) HHF2 [nucleoplasm] (R-SCE-4568758) HHF2 [nucleoplasm] (R-SCE-5229015) HHF2 [nucleoplasm] (R-SCE-4754243) HHF2 [nucleoplasm] (R-SCE-4754240) HHF2 [nucleoplasm] (R-SCE-5651656) HHF2 [nucleoplasm] (R-SCE-3451124) HHF2 [nucleoplasm] (R-SCE-2172676) HHF2 [nucleoplasm] (R-SCE-181902) HHF2 [nucleoplasm] (R-SCE-5651652)	0.564	8
UniProt:P32558	1	SPT16 [nucleoplasm] (R-SCE-112415)	0.564	14
UniProt:Q01477	2	UBP3 [nucleoplasm] (R-SCE-3222218) UBP3 [cytosol] (R-SCE-6782974)	0.527	2
UniProt:P10592	6	SSA2 [secretory granule lumen] (R-SCE-6801530) SSA2 [cytosol] (R-SCE-264476) SSA2 [extracellular region] (R-SCE-6805936) SSA2 [ficolin-1-rich granule lumen] (R-SCE-6801494) SSA2 [nucleoplasm] (R-SCE-5082380) SSA2 [nucleoplasm] (R-SCE-8932217)	0.527	2