Reactome | SEC23A [ER to Golgi transport vesicle membrane]

SEC23A [ER to Golgi transport vesicle membrane]

Stable Identifier

R-SCE-204024

Type

Protein [EntityWithAccessionedSequence]

Species

Saccharomyces cerevisiae

Compartment

ER to Golgi transport vesicle membrane

Synonyms

P15303

Locations in the PathwayBrowser

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Metabolism of proteins (Saccharomyces cerevisiae)

- Post-translational protein modification (Saccharomyces cerevisiae)
  - Asparagine N-linked glycosylation (Saccharomyces cerevisiae)
    - Transport to the Golgi and subsequent modification (Saccharomyces cerevisiae)
      - ER to Golgi Anterograde Transport (Saccharomyces cerevisiae)
        
        COPII-mediated vesicle transport (Saccharomyces cerevisiae)
        
        COPII coat binds TRAPPCII and RAB1:GDP (Saccharomyces cerevisiae)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Saccharomyces cerevisiae)
        
        SEC23:SEC24 [ER to Golgi transport vesicle membrane] (Saccharomyces cerevisiae)
        
        SEC23A [ER to Golgi transport vesicle membrane] (Saccharomyces cerevisiae)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Saccharomyces cerevisiae)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Saccharomyces cerevisiae)
        
        SEC23:SEC24 [ER to Golgi transport vesicle membrane] (Saccharomyces cerevisiae)
        
        SEC23A [ER to Golgi transport vesicle membrane] (Saccharomyces cerevisiae)
        
        CSNK1D phosphorylates SEC23 (Saccharomyces cerevisiae)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Saccharomyces cerevisiae)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Saccharomyces cerevisiae)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Saccharomyces cerevisiae)
        
        SEC23:SEC24 [ER to Golgi transport vesicle membrane] (Saccharomyces cerevisiae)
        
        SEC23A [ER to Golgi transport vesicle membrane] (Saccharomyces cerevisiae)
        
        Nucleotide exchange on RAB1 (Saccharomyces cerevisiae)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Saccharomyces cerevisiae)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Saccharomyces cerevisiae)
        
        SEC23:SEC24 [ER to Golgi transport vesicle membrane] (Saccharomyces cerevisiae)
        
        SEC23A [ER to Golgi transport vesicle membrane] (Saccharomyces cerevisiae)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Saccharomyces cerevisiae)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Saccharomyces cerevisiae)
        
        SEC23:SEC24 [ER to Golgi transport vesicle membrane] (Saccharomyces cerevisiae)
        
        SEC23A [ER to Golgi transport vesicle membrane] (Saccharomyces cerevisiae)

Vesicle-mediated transport (Saccharomyces cerevisiae)

- Membrane Trafficking (Saccharomyces cerevisiae)
  - ER to Golgi Anterograde Transport (Saccharomyces cerevisiae)
    - COPII-mediated vesicle transport (Saccharomyces cerevisiae)
      - COPII coat binds TRAPPCII and RAB1:GDP (Saccharomyces cerevisiae)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Saccharomyces cerevisiae)
        
        SEC23:SEC24 [ER to Golgi transport vesicle membrane] (Saccharomyces cerevisiae)
        
        SEC23A [ER to Golgi transport vesicle membrane] (Saccharomyces cerevisiae)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Saccharomyces cerevisiae)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Saccharomyces cerevisiae)
        
        SEC23:SEC24 [ER to Golgi transport vesicle membrane] (Saccharomyces cerevisiae)
        
        SEC23A [ER to Golgi transport vesicle membrane] (Saccharomyces cerevisiae)
      - CSNK1D phosphorylates SEC23 (Saccharomyces cerevisiae)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Saccharomyces cerevisiae)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Saccharomyces cerevisiae)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Saccharomyces cerevisiae)
        
        SEC23:SEC24 [ER to Golgi transport vesicle membrane] (Saccharomyces cerevisiae)
        
        SEC23A [ER to Golgi transport vesicle membrane] (Saccharomyces cerevisiae)
      - Nucleotide exchange on RAB1 (Saccharomyces cerevisiae)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Saccharomyces cerevisiae)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Saccharomyces cerevisiae)
        
        SEC23:SEC24 [ER to Golgi transport vesicle membrane] (Saccharomyces cerevisiae)
        
        SEC23A [ER to Golgi transport vesicle membrane] (Saccharomyces cerevisiae)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Saccharomyces cerevisiae)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Saccharomyces cerevisiae)
        
        SEC23:SEC24 [ER to Golgi transport vesicle membrane] (Saccharomyces cerevisiae)
        
        SEC23A [ER to Golgi transport vesicle membrane] (Saccharomyces cerevisiae)

External Reference Information

External Reference

UniProt:P15303

Reference Genes

BioGPS Gene:856311

ENSEMBL:YPR181C

KEGG Gene (Saccharomyces cerevisiae (strain RM11-1a)):YPR181C

Monarch:856311

NCBI Gene:856311

SGD:YPR181C

Reference Transcript

RefSeq:NM_001184278.1

Other Identifiers

1M2O

1M2V

2QTV

4932.YPR181C

4BZI

AAB68114.1

CAA33501.1

DAA11597.1

EntrezGene:856311

GO:0000139

GO:0003400

GO:0003674

GO:0005096

GO:0005575

GO:0005737

GO:0005783

GO:0005789

GO:0005794

GO:0006886

GO:0006888

GO:0008150

GO:0008270

GO:0012505

GO:0015031

GO:0016020

GO:0016050

GO:0016236

GO:0030127

GO:0030234

GO:0031410

GO:0033043

GO:0043167

GO:0043547

GO:0048193

GO:0051049

GO:0090114

IPR006895

IPR006896

IPR006900

IPR007123

IPR012990

IPR029006

IPR036174

IPR036175

IPR036180

IPR036465

IPR037364

IPR037550

NM_001184278.1

NP_015507.1

PF00626

PF04810

PF04811

PF04815

PF08033

UPI0000052F89

YPR181C

YPR181C_mRNA

Participant Of

hasComponent

SEC23:SEC24 [ER to Golgi transport vesicle membrane]

Other forms of this molecule

phospho-p-S742,T747 SEC23A [cytosol]

SEC23A [endoplasmic reticulum membrane]

SEC23A [cytosol]

Inferred From

SEC23A [ER to Golgi transport vesicle membrane] (Homo sapiens)

Cross References

RefSeq

NP_015507.1

PRO

P15303

PDB

2QTV, 4BZI, 6GNI, 1M2V, 1M2O

Interactors (16)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q04410	3	phospho-p-S189,T216,S274,S373-GORASP1 [Golgi membrane] (R-SCE-2314415) GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-SCE-162984) phospho-p-T216,S274,S373-GORASP1 [Golgi membrane] (R-SCE-2172182)	0.784	6
UniProt:P40482	8	phospho-p-SEC24B [cytosol] (R-SCE-5685746) phospho-p-SEC24A [cytosol] (R-SCE-5685743) SEC24A [cytosol] (R-SCE-203978) SEC24B [cytosol] (R-SCE-204001) SEC24B [endoplasmic reticulum membrane] (R-SCE-203982) SEC24A [endoplasmic reticulum membrane] (R-SCE-203992) SEC24B [ER to Golgi transport vesicle membrane] (R-SCE-204021) SEC24A [ER to Golgi transport vesicle membrane] (R-SCE-204022)	0.78	5
UniProt:P29295	3	CSNK1D [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-SCE-5685717) CSNK1D [nucleoplasm] (R-SCE-421305) CSNK1D [cytosol] (R-SCE-380315)	0.697	5
UniProt:P15108	6	HSP90AA1 [extracellular region] (R-SCE-3221946-2) HSP90AA1 [secretory granule lumen] (R-SCE-6801515-2) HSP90AA1 [ficolin-1-rich granule lumen] (R-SCE-6801470-2) HSP90AA1 [plasma membrane] (R-SCE-534996-2) HSP90AA1 [nucleoplasm] (R-SCE-5082401-2) HSP90AA1 [cytosol] (R-SCE-192864-2)	0.688	5
UniProt:P53953	4	SEC24A [cytosol] (R-SCE-203978-2) phospho-p-SEC24A [cytosol] (R-SCE-5685743-2) SEC24A [endoplasmic reticulum membrane] (R-SCE-203992-2) SEC24A [ER to Golgi transport vesicle membrane] (R-SCE-204022-2)	0.678	8
UniProt:P20606	2	SAR1B [endoplasmic reticulum membrane] (R-SCE-203995) SAR1B [cytosol] (R-SCE-174678)	0.667	3
UniProt:P38968	2	SEC31A [ER to Golgi transport vesicle membrane] (R-SCE-204010) SEC31A [cytosol] (R-SCE-203983)	0.632	3
UniProt:P48415	2	SEC16B [cytosol] (R-SCE-5685731) SEC16A [cytosol] (R-SCE-5685728)	0.632	5
UniProt:O75477 ERLIN1	1	ERLIN1 [endoplasmic reticulum membrane] (R-HSA-8866518)	0.556	3
UniProt:Q9BSE2 TMM79			0.556	3
UniProt:Q8IYX7 SAXO1			0.556	3
UniProt:P38810	8	phospho-p-SEC24C [cytosol] (R-SCE-5694551) phospho-p-SEC24D [cytosol] (R-SCE-5694554) SEC24D [endoplasmic reticulum membrane] (R-SCE-204004) SEC24C [endoplasmic reticulum membrane] (R-SCE-203987) SEC24C [cytosol] (R-SCE-203988) SEC24D [cytosol] (R-SCE-203990) SEC24C [ER to Golgi transport vesicle membrane] (R-SCE-204026) SEC24D [ER to Golgi transport vesicle membrane] (R-SCE-204020)	0.547	2
UniProt:P10591	23	HSPA8 [nucleoplasm] (R-SCE-5082380-2) HSPA8 [cytosol] (R-SCE-264476-2) HSPA6 [ficolin-1-rich granule lumen] (R-SCE-6801512-2) HSPA1A [ficolin-1-rich granule lumen] (R-SCE-6801496-2) HSPA8 [ficolin-1-rich granule lumen] (R-SCE-6801494-2) HSPA1A [extracellular region] (R-SCE-6805872-2) HSPA6 [extracellular region] (R-SCE-6806500-2) HSPA8 [extracellular region] (R-SCE-6805936-2) HSPA8 [secretory granule lumen] (R-SCE-6801530-2) HSPA6 [secretory granule lumen] (R-SCE-6801472-2) HSPA2 [nucleoplasm] (R-SCE-912480-2) HSPA1L [nucleoplasm] (R-SCE-5082367-2) HSPA1A [nucleoplasm] (R-SCE-6792605-2) HSPA6 [nucleoplasm] (R-SCE-5252088-2) HSPA13 [nucleoplasm] (R-SCE-5252009-2) HSPA7 [nucleoplasm] (R-SCE-5252047-2) HSPA1L [cytosol] (R-SCE-3371410-2) HSPA2 [cytosol] (R-SCE-3371408-2) HSPA13 [cytosol] (R-SCE-5251981-2) HSPA6 [cytosol] (R-SCE-3371521-2) HSPA7 [cytosol] (R-SCE-5251954-2) HSPA1A [cytosol] (R-SCE-6792602-2) Me3K561-HSPA8 [nucleoplasm] (R-SCE-8932217-2)	0.527	2
UniProt:P10592	23	HSPA8 [nucleoplasm] (R-SCE-5082380-3) HSPA8 [cytosol] (R-SCE-264476-3) HSPA6 [ficolin-1-rich granule lumen] (R-SCE-6801512-3) HSPA1A [ficolin-1-rich granule lumen] (R-SCE-6801496-3) HSPA8 [ficolin-1-rich granule lumen] (R-SCE-6801494-3) HSPA1A [extracellular region] (R-SCE-6805872-3) HSPA6 [extracellular region] (R-SCE-6806500-3) HSPA8 [extracellular region] (R-SCE-6805936-3) HSPA8 [secretory granule lumen] (R-SCE-6801530-3) HSPA6 [secretory granule lumen] (R-SCE-6801472-3) HSPA2 [nucleoplasm] (R-SCE-912480-3) HSPA1L [nucleoplasm] (R-SCE-5082367-3) HSPA1A [nucleoplasm] (R-SCE-6792605-3) HSPA6 [nucleoplasm] (R-SCE-5252088-3) HSPA13 [nucleoplasm] (R-SCE-5252009-3) HSPA7 [nucleoplasm] (R-SCE-5252047-3) HSPA1L [cytosol] (R-SCE-3371410-3) HSPA2 [cytosol] (R-SCE-3371408-3) HSPA13 [cytosol] (R-SCE-5251981-3) HSPA6 [cytosol] (R-SCE-3371521-3) HSPA7 [cytosol] (R-SCE-5251954-3) HSPA1A [cytosol] (R-SCE-6792602-3) Me3K561-HSPA8 [nucleoplasm] (R-SCE-8932217-3)	0.527	2
UniProt:P11484	23	HSPA8 [nucleoplasm] (R-SCE-5082380-4) HSPA8 [cytosol] (R-SCE-264476-4) HSPA6 [ficolin-1-rich granule lumen] (R-SCE-6801512-4) HSPA1A [ficolin-1-rich granule lumen] (R-SCE-6801496-4) HSPA8 [ficolin-1-rich granule lumen] (R-SCE-6801494-4) HSPA1A [extracellular region] (R-SCE-6805872-4) HSPA6 [extracellular region] (R-SCE-6806500-4) HSPA8 [extracellular region] (R-SCE-6805936-4) HSPA8 [secretory granule lumen] (R-SCE-6801530-4) HSPA6 [secretory granule lumen] (R-SCE-6801472-4) HSPA2 [nucleoplasm] (R-SCE-912480-4) HSPA1L [nucleoplasm] (R-SCE-5082367-4) HSPA1A [nucleoplasm] (R-SCE-6792605-4) HSPA6 [nucleoplasm] (R-SCE-5252088-4) HSPA13 [nucleoplasm] (R-SCE-5252009-4) HSPA7 [nucleoplasm] (R-SCE-5252047-4) HSPA1L [cytosol] (R-SCE-3371410-4) HSPA2 [cytosol] (R-SCE-3371408-4) HSPA13 [cytosol] (R-SCE-5251981-4) HSPA6 [cytosol] (R-SCE-3371521-4) HSPA7 [cytosol] (R-SCE-5251954-4) HSPA1A [cytosol] (R-SCE-6792602-4) Me3K561-HSPA8 [nucleoplasm] (R-SCE-8932217-4)	0.527	2
UniProt:Q99394	2	TRAPPC6B [cytosol] (R-SCE-5685735) TRAPPC6A [cytosol] (R-SCE-5685733)	0.499	3