Reactome | phospho-STE7 [cytosol]

phospho-STE7 [cytosol]

Stable Identifier

R-SCE-206255

Type

Protein [EntityWithAccessionedSequence]

Species

Saccharomyces cerevisiae

Compartment

cytosol

Synonyms

p-S207,T211-MAP2K6, P06784

Locations in the PathwayBrowser

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Immune System (Saccharomyces cerevisiae)

- Cytokine Signaling in Immune system (Saccharomyces cerevisiae)
  - Signaling by Interleukins (Saccharomyces cerevisiae)
    - Interleukin-17 signaling (Saccharomyces cerevisiae)
      - MAP kinase activation (Saccharomyces cerevisiae)
        
        activated TAK1 mediates p38 MAPK activation (Saccharomyces cerevisiae)
        
        Phosphorylated MKK3/MKK6 migrates to nucleus (Saccharomyces cerevisiae)
        
        p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [cytosol] (Saccharomyces cerevisiae)
        
        Homologues of p-S207,T211-MAP2K6 [cytosol] (Saccharomyces cerevisiae)
        
        phospho-STE7 [cytosol] (Saccharomyces cerevisiae)
- Innate Immune System (Saccharomyces cerevisiae)
  - Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways (Saccharomyces cerevisiae)
    - NOD1/2 Signaling Pathway (Saccharomyces cerevisiae)
      - Activation of p38 MAPK (Saccharomyces cerevisiae)
        
        Homologues of p-S207,T211-MAP2K6 [cytosol] (Saccharomyces cerevisiae)
        
        phospho-STE7 [cytosol] (Saccharomyces cerevisiae)
  - Toll-like Receptor Cascades (Saccharomyces cerevisiae)
    - Toll Like Receptor 10 (TLR10) Cascade (Saccharomyces cerevisiae)
      - MyD88 cascade initiated on plasma membrane (Saccharomyces cerevisiae)
        
        MAP kinase activation (Saccharomyces cerevisiae)
        
        activated TAK1 mediates p38 MAPK activation (Saccharomyces cerevisiae)
        
        Phosphorylated MKK3/MKK6 migrates to nucleus (Saccharomyces cerevisiae)
        
        p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [cytosol] (Saccharomyces cerevisiae)
        
        Homologues of p-S207,T211-MAP2K6 [cytosol] (Saccharomyces cerevisiae)
        
        phospho-STE7 [cytosol] (Saccharomyces cerevisiae)
    - Toll Like Receptor 2 (TLR2) Cascade (Saccharomyces cerevisiae)
      - Toll Like Receptor TLR1:TLR2 Cascade (Saccharomyces cerevisiae)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Saccharomyces cerevisiae)
        
        MAP kinase activation (Saccharomyces cerevisiae)
        
        activated TAK1 mediates p38 MAPK activation (Saccharomyces cerevisiae)
        
        Phosphorylated MKK3/MKK6 migrates to nucleus (Saccharomyces cerevisiae)
        
        p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [cytosol] (Saccharomyces cerevisiae)
        
        Homologues of p-S207,T211-MAP2K6 [cytosol] (Saccharomyces cerevisiae)
        
        phospho-STE7 [cytosol] (Saccharomyces cerevisiae)
      - Toll Like Receptor TLR6:TLR2 Cascade (Saccharomyces cerevisiae)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Saccharomyces cerevisiae)
        
        MAP kinase activation (Saccharomyces cerevisiae)
        
        activated TAK1 mediates p38 MAPK activation (Saccharomyces cerevisiae)
        
        Phosphorylated MKK3/MKK6 migrates to nucleus (Saccharomyces cerevisiae)
        
        p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [cytosol] (Saccharomyces cerevisiae)
        
        Homologues of p-S207,T211-MAP2K6 [cytosol] (Saccharomyces cerevisiae)
        
        phospho-STE7 [cytosol] (Saccharomyces cerevisiae)
    - Toll Like Receptor 3 (TLR3) Cascade (Saccharomyces cerevisiae)
      - MAP kinase activation (Saccharomyces cerevisiae)
        
        activated TAK1 mediates p38 MAPK activation (Saccharomyces cerevisiae)
        
        Phosphorylated MKK3/MKK6 migrates to nucleus (Saccharomyces cerevisiae)
        
        p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [cytosol] (Saccharomyces cerevisiae)
        
        Homologues of p-S207,T211-MAP2K6 [cytosol] (Saccharomyces cerevisiae)
        
        phospho-STE7 [cytosol] (Saccharomyces cerevisiae)
    - Toll Like Receptor 4 (TLR4) Cascade (Saccharomyces cerevisiae)
      - MyD88-independent TLR4 cascade (Saccharomyces cerevisiae)
        
        TRIF(TICAM1)-mediated TLR4 signaling (Saccharomyces cerevisiae)
        
        MAP kinase activation (Saccharomyces cerevisiae)
        
        activated TAK1 mediates p38 MAPK activation (Saccharomyces cerevisiae)
        
        Phosphorylated MKK3/MKK6 migrates to nucleus (Saccharomyces cerevisiae)
        
        p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [cytosol] (Saccharomyces cerevisiae)
        
        Homologues of p-S207,T211-MAP2K6 [cytosol] (Saccharomyces cerevisiae)
        
        phospho-STE7 [cytosol] (Saccharomyces cerevisiae)
      - MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Saccharomyces cerevisiae)
        
        MAP kinase activation (Saccharomyces cerevisiae)
        
        activated TAK1 mediates p38 MAPK activation (Saccharomyces cerevisiae)
        
        Phosphorylated MKK3/MKK6 migrates to nucleus (Saccharomyces cerevisiae)
        
        p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [cytosol] (Saccharomyces cerevisiae)
        
        Homologues of p-S207,T211-MAP2K6 [cytosol] (Saccharomyces cerevisiae)
        
        phospho-STE7 [cytosol] (Saccharomyces cerevisiae)
    - Toll Like Receptor 5 (TLR5) Cascade (Saccharomyces cerevisiae)
      - MyD88 cascade initiated on plasma membrane (Saccharomyces cerevisiae)
        
        MAP kinase activation (Saccharomyces cerevisiae)
        
        activated TAK1 mediates p38 MAPK activation (Saccharomyces cerevisiae)
        
        Phosphorylated MKK3/MKK6 migrates to nucleus (Saccharomyces cerevisiae)
        
        p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [cytosol] (Saccharomyces cerevisiae)
        
        Homologues of p-S207,T211-MAP2K6 [cytosol] (Saccharomyces cerevisiae)
        
        phospho-STE7 [cytosol] (Saccharomyces cerevisiae)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Saccharomyces cerevisiae)
      - MyD88 dependent cascade initiated on endosome (Saccharomyces cerevisiae)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Saccharomyces cerevisiae)
        
        MAP kinase activation (Saccharomyces cerevisiae)
        
        activated TAK1 mediates p38 MAPK activation (Saccharomyces cerevisiae)
        
        Phosphorylated MKK3/MKK6 migrates to nucleus (Saccharomyces cerevisiae)
        
        p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [cytosol] (Saccharomyces cerevisiae)
        
        Homologues of p-S207,T211-MAP2K6 [cytosol] (Saccharomyces cerevisiae)
        
        phospho-STE7 [cytosol] (Saccharomyces cerevisiae)
    - Toll Like Receptor 9 (TLR9) Cascade (Saccharomyces cerevisiae)
      - MyD88 dependent cascade initiated on endosome (Saccharomyces cerevisiae)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Saccharomyces cerevisiae)
        
        MAP kinase activation (Saccharomyces cerevisiae)
        
        activated TAK1 mediates p38 MAPK activation (Saccharomyces cerevisiae)
        
        Phosphorylated MKK3/MKK6 migrates to nucleus (Saccharomyces cerevisiae)
        
        p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [cytosol] (Saccharomyces cerevisiae)
        
        Homologues of p-S207,T211-MAP2K6 [cytosol] (Saccharomyces cerevisiae)
        
        phospho-STE7 [cytosol] (Saccharomyces cerevisiae)

External Reference Information

External Reference

UniProt:P06784

Gene Names

STE7

Reference Genes

BioGPS Gene:851396 STE7

ENSEMBL:YDL159W

KEGG Gene (Saccharomyces cerevisiae (strain RM11-1a)):YDL159W STE7

Monarch:851396 STE7

NCBI Gene:851396 STE7

SGD:YDL159W

Reference Transcript

RefSeq:NM_001180219.1 STE7

Other Identifiers

1769361_at

6661_at

851396

GO:0000165

GO:0000187

GO:0000196

GO:0000278

GO:0001402

GO:0001403

GO:0003674

GO:0004672

GO:0004674

GO:0004708

GO:0005524

GO:0005575

GO:0005737

GO:0006468

GO:0007124

GO:0007346

GO:0008150

GO:0010525

GO:0016301

GO:0016740

GO:0019236

GO:0023052

GO:0030427

GO:0031098

GO:0031399

GO:0032196

GO:0042221

GO:0042981

GO:0043167

GO:0043332

GO:0051726

GO:0071554

Participant Of

hasMember

Homologues of p-S207,T211-MAP2K6 [cytosol]

Other forms of this molecule

phospho-STE7 [cytosol]

STE7 [cytosol]

phospho-STE7 [cytosol]

STE7 [cytosol]

phospho-STE7 [cytosol]

phospho-STE7 [nucleoplasm]

phospho-STE7 [cytosol]

STE7 [cytosol]

phospho-STE7 [cytosol]

Inferred From

p-S207,T211-MAP2K6 [cytosol] (Homo sapiens)

Modified Residues

Name

O-phospho-L-serine at 207 (in Homo sapiens)

Coordinate

207

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-threonine at 211 (in Homo sapiens)

Coordinate

211

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Cross References

RefSeq

NP_010122.1

PRO

P06784

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P16892	11	FUS3 [extracellular region] (R-SCE-6806250) FUS3 [azurophil granule lumen] (R-SCE-6799225) FUS3 [ficolin-1-rich granule lumen] (R-SCE-6800964) FUS3 [nucleoplasm] (R-SCE-199960) FUS3 [nucleoplasm] (R-SCE-73724-2) FUS3 [cytosol] (R-SCE-59284-2) phospho-FUS3 [cytosol] (R-SCE-109842-2) phospho-FUS3 [cytosol] (R-SCE-109853) FUS3 [cytosol] (R-SCE-59282) phospho-FUS3 [nucleoplasm] (R-SCE-112359-2) phospho-FUS3 [nucleoplasm] (R-SCE-112354)	0.932	15
UniProt:Q00684	3	CDC14 [nucleoplasm] (R-SCE-5692694) CDC14 [cytosol] (R-SCE-174094) CDC14 [nucleoplasm] (R-SCE-3214897)	0.499	2

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