Reactome | HSP90AA1 [extracellular region]

HSP90AA1 [extracellular region]

Stable Identifier

R-SCE-3221946

Type

Protein [EntityWithAccessionedSequence]

Species

Saccharomyces cerevisiae

Compartment

extracellular region

Synonyms

P02829

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P02829

Reference Genes

BioGPS Gene:855836

ENSEMBL:YPL240C

KEGG Gene (Saccharomyces cerevisiae (strain RM11-1a)):YPL240C

KEGG Gene (Saccharomyces cerevisiae):YPL240C

Monarch:855836

NCBI Gene:855836

SGD:YPL240C

Reference Transcript

RefSeq:NM_001184054.1

Other Identifiers

1773612_at

8010_i_at

855836

9457_g_at

GO:0000166

GO:0000492

GO:0003674

GO:0005515

GO:0005524

GO:0005575

GO:0005634

GO:0005737

GO:0005829

GO:0005886

GO:0006457

GO:0006458

GO:0006605

GO:0006626

GO:0006970

GO:0007005

GO:0008150

GO:0009408

GO:0015031

GO:0016020

GO:0016787

GO:0016887

GO:0032200

GO:0032204

GO:0032212

GO:0032991

GO:0033043

GO:0034605

GO:0042026

GO:0042623

GO:0042802

GO:0043167

GO:0043248

GO:0048471

GO:0050821

GO:0051052

GO:0051082

GO:0051604

GO:0070482

GO:0140657

GO:0140662

Participates

as a member of

Homologues of HSP90AA1 [extracellular region] (Saccharomyces cerevisiae)

Other forms of this molecule

HSP90AB1 [secretory granule lumen]

HSP90AA1 [secretory granule lumen]

HSP90AB1 [extracellular region]

HSP90AA1 [ficolin-1-rich granule lumen]

HSP90AB1 [ficolin-1-rich granule lumen]

HSP90AA1 [plasma membrane]

HSP90AB1 [cytosol]

HSP90AA1 [nucleoplasm]

HSP90AB1 [nucleoplasm]

HSP90AA1 [cytosol]

Inferred From

HSP90AA1 [extracellular region] (Homo sapiens)

Cross References

ZINC - Investigational

HSP82_YEAST

RefSeq

NP_015084.1

ZINC - Substances

HSP82_YEAST

ZINC target

P02829

PRO

P02829

ZINC - Predictions - Purchasable

HSP82_YEAST

PDB

2CGF, 2YGE, 2BRE, 1USU, 2YGF, 2BRC, 2CGE, 4ASA, 5MGX, 2WEP, 1ZW9, 2WEQ, 2VW5, 4ASB, 1AM1, 3C0E, 2LSV, 1A4H, 2CG9, 2XX2, 2AKP, 2FXS, 2IWX, 2XX4, 2WER, 1BGQ, 4ASF, 2VWC, 3C11, 1US7, 4ASG, 2XD6, 2IWU, 2XX5, 1AMW, 4CE1, 1AH8, 2IWS, 4CE2, 1AH6, 1HK7, 3FP2, 2YGA, 4AS9, 4CE3, 1USV, 1ZWH

Interactors (111)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P15705	1	STI1 [cytosol] (R-SCE-443857)	0.971	43
UniProt:Q12449 AHA1			0.957	15
UniProt:P02829	11	HSP90AB1 [secretory granule lumen] (R-SCE-6801477) HSP90AA1 [secretory granule lumen] (R-SCE-6801515) HSP90AB1 [extracellular region] (R-SCE-6806463) HSP90AA1 [extracellular region] (R-SCE-3221946) HSP90AA1 [ficolin-1-rich granule lumen] (R-SCE-6801470) HSP90AB1 [ficolin-1-rich granule lumen] (R-SCE-6801491) HSP90AA1 [plasma membrane] (R-SCE-534996) HSP90AB1 [cytosol] (R-SCE-419617) HSP90AA1 [nucleoplasm] (R-SCE-5082401) HSP90AB1 [nucleoplasm] (R-SCE-5082399) HSP90AA1 [cytosol] (R-SCE-192864)	0.943	11
UniProt:P53691	4	CPR6 [secretory granule lumen] (R-SCE-6801369) CPR6 [extracellular region] (R-SCE-6806493) CPR6 [ficolin-1-rich granule lumen] (R-SCE-6801393) CPR6 [nucleoplasm] (R-SCE-6781959)	0.935	27
UniProt:P25638 TAH1			0.922	11
UniProt:P53043	1	PPP5C [nucleoplasm] (R-SCE-5683410)	0.912	13
UniProt:P28707	2	SBA1 [cytosol] (R-SCE-265269) SBA1 [nucleoplasm] (R-SCE-5082403)	0.866	7
UniProt:P33313 CNS1			0.851	7
UniProt:P38768 PIH1			0.815	5
UniProt:P06101	3	CDC37 [extracellular region] (R-SCE-8848918) CDC37 [platelet dense granule lumen] (R-SCE-8848903) CDC37 [cytosol] (R-SCE-1221609)	0.791	6
UniProt:P47103	1	CPR7 [nucleoplasm] (R-SCE-8939168)	0.771	6
UniProt:Q00772	13	phospho-p-T218,Y221-MAPK7 [nucleoplasm] (R-SCE-198738) phospho-p-T218,Y221-MAPK7 [cytosol] (R-SCE-198721) MAPK7 [nucleoplasm] (R-SCE-199961) phospho-p-3S,T MAPK6 [nucleoplasm] (R-SCE-5692665-2) MAPK6 [nucleoplasm] (R-SCE-5692686-2) phospho-p-S189 MAPK6 [nucleoplasm] (R-SCE-5687015-2) phospho-p-S186 MAPK4 [nucleoplasm] (R-SCE-5687022-2) phospho-p-S186 MAPK4 [cytosol] (R-SCE-5687023-2) phospho-p-S189 MAPK6 [cytosol] (R-SCE-5687019-2) MAPK6 [cytosol] (R-SCE-5686979-2) MAPK4 [cytosol] (R-SCE-5686973-2) MAPK4 [nucleoplasm] (R-SCE-5686975-2) ub-MAPK6 [cytosol] (R-SCE-5687000-2)	0.75	5
UniProt:P10591	2	SSA1 [nucleoplasm] (R-SCE-912480-2) SSA1 [cytosol] (R-SCE-3371408-2)	0.744	5
UniProt:P32589 HSP7F			0.721	5
UniProt:P0CS82 HAP1			0.721	4
UniProt:P38828 LSM12			0.688	3
UniProt:P33322	1	CBF5 [nucleoplasm] (R-SCE-163102)	0.688	4
UniProt:Q12407 YD199			0.678	3
UniProt:P15108	6	HSP90AA1 [secretory granule lumen] (R-SCE-6801515-2) HSP90AA1 [extracellular region] (R-SCE-3221946-2) HSP90AA1 [ficolin-1-rich granule lumen] (R-SCE-6801470-2) HSP90AA1 [plasma membrane] (R-SCE-534996-2) HSP90AA1 [nucleoplasm] (R-SCE-5082401-2) HSP90AA1 [cytosol] (R-SCE-192864-2)	0.678	46
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.678	8
UniProt:P10592	8	SSA2 [cytosol] (R-SCE-264476) SSA2 [nucleoplasm] (R-SCE-5082380) SSA2 [ficolin-1-rich granule lumen] (R-SCE-6801494) SSA2 [extracellular region] (R-SCE-6805936) SSA2 [secretory granule lumen] (R-SCE-6801530) SSA2 [cytosol] (R-SCE-3371408-3) SSA2 [nucleoplasm] (R-SCE-912480-3) SSA2 [nucleoplasm] (R-SCE-8932217)	0.669	3
UniProt:P41808	10	ub-MAPK6 [cytosol] (R-SCE-5687000) MAPK4 [nucleoplasm] (R-SCE-5686975) MAPK4 [cytosol] (R-SCE-5686973) MAPK6 [cytosol] (R-SCE-5686979) phospho-p-S189 MAPK6 [cytosol] (R-SCE-5687019) phospho-p-S186 MAPK4 [cytosol] (R-SCE-5687023) phospho-p-S186 MAPK4 [nucleoplasm] (R-SCE-5687022) phospho-p-S189 MAPK6 [nucleoplasm] (R-SCE-5687015) MAPK6 [nucleoplasm] (R-SCE-5692686) phospho-p-3S,T MAPK6 [nucleoplasm] (R-SCE-5692665)	0.659	4
UniProt:Q08446	1	SGT1 [cytosol] (R-SCE-874107)	0.623	2
UniProt:P15442 GCN2	2	GCN2 [cytosol] (R-SCE-9633552) p-T882,887-GCN2 [cytosol] (R-SCE-9633799)	0.621	3
UniProt:P25491	2	DNAJA2 [cytosol] (R-SCE-3371555) DNAJA4 [cytosol] (R-SCE-3371578)	0.621	3
UniProt:P60010	4	ACT1 [cytosol] (R-SCE-390536) ACT1 [extracellular region] (R-SCE-350725) ACT1 [cytosol] (R-SCE-201861) ACT1 [plasma membrane] (R-SCE-196016)	0.61	3
UniProt:P43581 HXT10			0.573	2
UniProt:Q08109 HRD1			0.564	3
UniProt:P25635 PWP2	2	PWP2 [nucleoplasm] (R-SCE-6790632) PWP2 [nucleoplasm] (R-SCE-6790680)	0.564	2
UniProt:P39534 MBB1			0.564	2
UniProt:Q07825	2	cleaved GPI-XPNPEP2 [extracellular region] (R-SCE-8943379) GPI-XPNPEP2 [plasma membrane] (R-SCE-8940794)	0.564	2
UniProt:P53834 HCH1			0.564	2
UniProt:P32832 RSC7			0.564	2
UniProt:P46672 ARC1			0.564	2
UniProt:P38264 PHO88			0.564	2
UniProt:P00359	2	GAPDH [cytosol] (R-SCE-70428) GAPDHS [cytosol] (R-SCE-372873-2)	0.564	2
UniProt:P38788 SSZ1			0.564	3
UniProt:P11484	2	HSPA2 [cytosol] (R-SCE-3371408-4) HSPA2 [nucleoplasm] (R-SCE-912480-4)	0.564	3
UniProt:Q12276 HER1			0.564	2
UniProt:P53743 ESF2			0.564	2
UniProt:P38241 SLT11			0.564	4
UniProt:P41811	3	SEC27 [endoplasmic reticulum membrane] (R-SCE-6810957) SEC27 [transport vesicle] (R-SCE-6808741) SEC27 [cytosol] (R-SCE-199972)	0.564	2
UniProt:P38887 YH02			0.564	2
UniProt:P17883 SKI3	1	SKI3 [cytosol] (R-SCE-8931541)	0.564	2
UniProt:P38764	4	RPN1 [secretory granule lumen] (R-SCE-6800919) RPN1 [cytosol] (R-SCE-68796) RPN1 [ficolin-1-rich granule lumen] (R-SCE-6800435) RPN1 [extracellular region] (R-SCE-6806479)	0.564	2
UniProt:P33759 RT05			0.564	12
UniProt:P53599 SSK2			0.564	2
UniProt:P53874	1	UBP10 [cytosol] (R-SCE-6782780)	0.564	2
UniProt:Q06224	1	CPSF3 [nucleoplasm] (R-SCE-71993)	0.564	2
UniProt:Q01454 CTF4			0.564	2
UniProt:P00830 ATP2	4	ATP2 [mitochondrial inner membrane] (R-SCE-1267966) ATP2 precursor [mitochondrial inner membrane] (R-SCE-1252057) ATP2 precursor [mitochondrial intermembrane space] (R-SCE-1252202) ATP2 precursor [cytosol] (R-SCE-1252203)	0.564	2
UniProt:Q12102	1	CFT2 [nucleoplasm] (R-SCE-71991)	0.564	2
UniProt:P38746 YLF2			0.564	2
UniProt:Q07786	1	SORD [cytosol] (R-SCE-5652193-2)	0.553	2
UniProt:P38272 SHE3			0.553	2
UniProt:P38356 BSD2			0.553	2
UniProt:Q06598 ARR3			0.553	2
UniProt:Q12051	1	GGPS1 [cytosol] (R-SCE-191415)	0.547	2
UniProt:P38555	5	RAB11B [recycling endosome membrane] (R-SCE-8854762) GGC-RAB11B [cytosol] (R-SCE-8873766) GGC-RAB25 [cytosol] (R-SCE-8873780) RAB11B [cytosol] (R-SCE-8873671) RAB25 [cytosol] (R-SCE-8873683)	0.547	2
UniProt:Q06604 BSP1			0.547	2
UniProt:Q08227	7	INP54 [Golgi membrane] (R-SCE-434339) INP54 [cytoplasmic vesicle membrane] (R-SCE-434214) INP54 [plasma membrane] (R-SCE-2023845) INP54 [plasma membrane] (R-SCE-3769049) INP54 [cytosol] (R-SCE-1806196) INP54 [cytosol] (R-SCE-1604590) INP54 [cytosol] (R-SCE-1806175)	0.547	2
UniProt:Q06696	1	VPS36 [cytosol] (R-SCE-917709)	0.547	2
UniProt:Q12329 HSP42			0.547	2
UniProt:P19882 HSP60	6	HSP60 [mitochondrial matrix] (R-SCE-1252181) HSP60 [mitochondrial inner membrane] (R-SCE-1267982) HSP60 precursor [mitochondrial inner membrane] (R-SCE-1267967) HSP60 precursor [mitochondrial intermembrane space] (R-SCE-1252158) HSP60 [cytosol] (R-SCE-1252153) HSP60 [mitochondrial matrix] (R-SCE-8986171)	0.547	2
UniProt:P07248 ADR1			0.547	2
UniProt:P38720	1	PGD [cytosol] (R-SCE-71297)	0.547	2
UniProt:P32468	2	SEPT4 [cytosol] (R-SCE-6805825) SEPT4 [mitochondrial outer membrane] (R-SCE-6805816)	0.547	2
UniProt:P22516 CHL1			0.547	2
UniProt:P46956 PHO86			0.547	2
UniProt:P38429	2	SAP30 [nucleoplasm] (R-SCE-351693) SAP30 [nucleoplasm] (R-SCE-351698)	0.547	2
UniProt:P25644	1	PAT1 [cytosol] (R-SCE-2028617)	0.547	2
UniProt:Q07732 ADY3			0.547	2
UniProt:Q06523 YP148			0.547	2
UniProt:Q08278 MED7			0.547	2
UniProt:Q06892 POS5			0.547	2
UniProt:P22203	2	VMA4 [cytosol] (R-SCE-912579) VMA4 [cytosol] (R-SCE-912606)	0.547	2
UniProt:P04076	1	ASL [cytosol] (R-SCE-70570)	0.547	2
UniProt:P02293 H2B1			0.547	2
UniProt:P33200 PDR3			0.547	2
UniProt:Q06106 MRD1			0.547	2
UniProt:P20967	1	KGD1 [mitochondrial matrix] (R-SCE-69981)	0.547	2
UniProt:P38866 FMO1			0.547	3
UniProt:P32485	14	MAPK12 [nucleoplasm] (R-SCE-448833) MAPK14 [secretory granule lumen] (R-SCE-6803300) MAPK14 [extracellular region] (R-SCE-6806453) MAPK14 [ficolin-1-rich granule lumen] (R-SCE-6803280) phospho-p-T183,Y185-MAPK12 [cytosol] (R-SCE-171021) phospho-p-T180,Y182-MAPK13 [cytosol] (R-SCE-171022) phospho-p-T180,Y182-MAPK11 [cytosol] (R-SCE-171009) MAPK11 [cytosol] (R-SCE-170989) MAPK13 [cytosol] (R-SCE-171012) MAPK12 [cytosol] (R-SCE-171025) MAPK14 [cytosol] (R-SCE-428933) phospho-p-T180,Y182-MAPK14 [cytosol] (R-SCE-428935) phospho-p-T180,Y182-MAPK11 [nucleoplasm] (R-SCE-198741) phospho-p-T180,Y182-MAPK14 [nucleoplasm] (R-SCE-446227)	0.547	2
UniProt:P04802 SYDC			0.547	2
UniProt:Q99190	2	TSC13 [endoplasmic reticulum membrane] (R-SCE-548663) TSC13 [endoplasmic reticulum membrane] (R-SCE-4127427)	0.547	2
UniProt:Q08144	1	TLG2 [trans-Golgi network membrane] (R-SCE-6811002)	0.547	2
UniProt:Q12511 PDP1			0.547	2
UniProt:P06700	1	SIRT1 [nucleoplasm] (R-SCE-427531)	0.547	2
UniProt:P14681	13	MAPK1 [azurophil granule lumen] (R-SCE-6799225) MAPK1 [extracellular region] (R-SCE-6806250) MAPK1 [ficolin-1-rich granule lumen] (R-SCE-6800964) phospho-p-T202-MAPK3 [cytosol] (R-SCE-9635775) phospho-p-T185-MAPK1 [cytosol] (R-SCE-9635773) MAPK1 [nucleoplasm] (R-SCE-199960) MAPK3 [nucleoplasm] (R-SCE-73724) MAPK3 [cytosol] (R-SCE-59284) MAPK1 [cytosol] (R-SCE-59282) phospho-p-T185,Y187-MAPK1 [cytosol] (R-SCE-109853) phospho-p-T202,Y204-MAPK3 [cytosol] (R-SCE-109842) phospho-p-T202,Y204-MAPK3 [nucleoplasm] (R-SCE-112359) phospho-p-T185,Y187-MAPK1 [nucleoplasm] (R-SCE-112354)	0.547	2
UniProt:P27636	3	NRBP1 [nucleoplasm] (R-SCE-376332) MAP3K1 [cytosol] (R-SCE-166866) phospho-p-T1400,T1412-MAP3K1 [cytosol] (R-SCE-2685607)	0.547	2
UniProt:P40359	1	PSF2 [nucleoplasm] (R-SCE-176975)	0.527	2
UniProt:P04385 GAL1			0.527	2
UniProt:P39011 GDS1			0.527	2
UniProt:P38688	1	SRP72 [cytosol] (R-SCE-265069)	0.527	2
UniProt:P27801 PEP3			0.527	2
UniProt:Q03330	2	KAT2B [nucleoplasm] (R-SCE-352430) KAT2A [nucleoplasm] (R-SCE-3006516)	0.527	2
UniProt:P54860	1	UFD2 [cytosol] (R-SCE-976022)	0.527	2
UniProt:P32259 MED16			0.527	2
UniProt:P12753 RAD50	1	DNA repair protein RAD50 [nucleoplasm] (R-SCE-981774)	0.527	2
UniProt:P38129	1	TAF5 [nucleoplasm] (R-SCE-65543)	0.527	3
UniProt:P17157 PHO85			0.527	2
UniProt:P52918	2	MSN5 [cytosol] (R-SCE-847719) MSN5 [nucleoplasm] (R-SCE-847721)	0.527	2
UniProt:Q12347	1	HRT3 [cytosol] (R-SCE-8862608)	0.527	2
UniProt:P38629	1	RFC5 [nucleoplasm] (R-SCE-68427)	0.527	2
UniProt:Q06640	9	PolyUb-K109-FBXL7 [cytosol] (R-SCE-8854053-2) FBXL5 [cytosol] (R-SCE-391295-2) FBXL20 [cytosol] (R-SCE-8862591-2) FBXL15 [cytosol] (R-SCE-8862625-2) FBXL13 [cytosol] (R-SCE-8862616-2) FBXL7 [cytosol] (R-SCE-8854032-2) FBXL16 [cytosol] (R-SCE-8862609-2) FBXL14 [cytosol] (R-SCE-8862603) FBXL4 [cytosol] (R-SCE-8850899-2)	0.527	2
UniProt:Q08387 DNLI4			0.527	2
UniProt:P22336 RFA1			0.527	2
UniProt:P27616 PUR7			0.508	2
UniProt:P37898	6	ANPEP [plasma membrane] (R-SCE-2022340-2) ANPEP [secretory granule membrane] (R-SCE-6806152-2) NPEPPS [cytosol] (R-SCE-983056-2) LNPEP [cytosol] (R-SCE-983098-2) ERAP1 [endoplasmic reticulum lumen] (R-SCE-947609-2) ERAP2 [endoplasmic reticulum lumen] (R-SCE-983097-2)	0.508	4
UniProt:P53858	2	BNI4 [plasma membrane] (R-SCE-8848883) BNI4 [platelet alpha granule membrane] (R-SCE-8848893)	0.508	2
UniProt:P23561	1	MAP3K5 [cytosol] (R-SCE-167709)	0.488	2

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