Reactome | CHC1 [cytosol]

CHC1 [cytosol]

Stable Identifier

R-SCE-350824

Type

Protein [EntityWithAccessionedSequence]

Species

Saccharomyces cerevisiae

Compartment

cytosol

Synonyms

CLTC-1, P22137

Locations in the PathwayBrowser

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Vesicle-mediated transport (Saccharomyces cerevisiae)

- Membrane Trafficking (Saccharomyces cerevisiae)
  - Clathrin-mediated endocytosis (Saccharomyces cerevisiae)
    - AAK1 phosphorylates AP-2 mu subunit at T156 (Saccharomyces cerevisiae)
      - PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Saccharomyces cerevisiae)
        
        Clathrin Triskelion [cytosol] (Saccharomyces cerevisiae)
        
        CHC1 [cytosol] (Saccharomyces cerevisiae)
        
        PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Saccharomyces cerevisiae)
        
        PI(4,5)P2:AP-2:clathrin [plasma membrane] (Saccharomyces cerevisiae)
        
        Clathrin Triskelion [cytosol] (Saccharomyces cerevisiae)
        
        CHC1 [cytosol] (Saccharomyces cerevisiae)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Saccharomyces cerevisiae)
        
        Clathrin Triskelion [cytosol] (Saccharomyces cerevisiae)
        
        CHC1 [cytosol] (Saccharomyces cerevisiae)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Saccharomyces cerevisiae)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Saccharomyces cerevisiae)
        
        Clathrin Triskelion [cytosol] (Saccharomyces cerevisiae)
        
        CHC1 [cytosol] (Saccharomyces cerevisiae)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Saccharomyces cerevisiae)
        
        Clathrin Triskelion [cytosol] (Saccharomyces cerevisiae)
        
        CHC1 [cytosol] (Saccharomyces cerevisiae)
    - BAR domain proteins recruit dynamin (Saccharomyces cerevisiae)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Saccharomyces cerevisiae)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Saccharomyces cerevisiae)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Saccharomyces cerevisiae)
        
        Clathrin Triskelion [cytosol] (Saccharomyces cerevisiae)
        
        CHC1 [cytosol] (Saccharomyces cerevisiae)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Saccharomyces cerevisiae)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Saccharomyces cerevisiae)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Saccharomyces cerevisiae)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Saccharomyces cerevisiae)
        
        Clathrin Triskelion [cytosol] (Saccharomyces cerevisiae)
        
        CHC1 [cytosol] (Saccharomyces cerevisiae)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Saccharomyces cerevisiae)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Saccharomyces cerevisiae)
        
        Clathrin Triskelion [cytosol] (Saccharomyces cerevisiae)
        
        CHC1 [cytosol] (Saccharomyces cerevisiae)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Saccharomyces cerevisiae)
        
        Clathrin Triskelion [cytosol] (Saccharomyces cerevisiae)
        
        CHC1 [cytosol] (Saccharomyces cerevisiae)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Saccharomyces cerevisiae)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Saccharomyces cerevisiae)
        
        Clathrin Triskelion [cytosol] (Saccharomyces cerevisiae)
        
        CHC1 [cytosol] (Saccharomyces cerevisiae)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Saccharomyces cerevisiae)
        
        Clathrin Triskelion [cytosol] (Saccharomyces cerevisiae)
        
        CHC1 [cytosol] (Saccharomyces cerevisiae)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Saccharomyces cerevisiae)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Saccharomyces cerevisiae)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Saccharomyces cerevisiae)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Saccharomyces cerevisiae)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Saccharomyces cerevisiae)
        
        Clathrin Triskelion [cytosol] (Saccharomyces cerevisiae)
        
        CHC1 [cytosol] (Saccharomyces cerevisiae)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Saccharomyces cerevisiae)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Saccharomyces cerevisiae)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Saccharomyces cerevisiae)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Saccharomyces cerevisiae)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Saccharomyces cerevisiae)
        
        Clathrin Triskelion [cytosol] (Saccharomyces cerevisiae)
        
        CHC1 [cytosol] (Saccharomyces cerevisiae)
    - FCHo proteins bind nascent clathrin-coated pit (Saccharomyces cerevisiae)
      - PI(4,5)P2:AP-2:clathrin [plasma membrane] (Saccharomyces cerevisiae)
        
        Clathrin Triskelion [cytosol] (Saccharomyces cerevisiae)
        
        CHC1 [cytosol] (Saccharomyces cerevisiae)
      - PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Saccharomyces cerevisiae)
        
        PI(4,5)P2:AP-2:clathrin [plasma membrane] (Saccharomyces cerevisiae)
        
        Clathrin Triskelion [cytosol] (Saccharomyces cerevisiae)
        
        CHC1 [cytosol] (Saccharomyces cerevisiae)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Saccharomyces cerevisiae)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Saccharomyces cerevisiae)
        
        Clathrin Triskelion [cytosol] (Saccharomyces cerevisiae)
        
        CHC1 [cytosol] (Saccharomyces cerevisiae)
      - clathrin:HSPA8:ADP [cytosol] (Saccharomyces cerevisiae)
        
        Clathrin Triskelion [cytosol] (Saccharomyces cerevisiae)
        
        CHC1 [cytosol] (Saccharomyces cerevisiae)
    - Initial binding of AP-2 and clathrin to PI(4,5)P2 (Saccharomyces cerevisiae)
      - Clathrin Triskelion [cytosol] (Saccharomyces cerevisiae)
        
        CHC1 [cytosol] (Saccharomyces cerevisiae)
      - PI(4,5)P2:AP-2:clathrin [plasma membrane] (Saccharomyces cerevisiae)
        
        Clathrin Triskelion [cytosol] (Saccharomyces cerevisiae)
        
        CHC1 [cytosol] (Saccharomyces cerevisiae)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Saccharomyces cerevisiae)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Saccharomyces cerevisiae)
        
        Clathrin Triskelion [cytosol] (Saccharomyces cerevisiae)
        
        CHC1 [cytosol] (Saccharomyces cerevisiae)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Saccharomyces cerevisiae)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Saccharomyces cerevisiae)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Saccharomyces cerevisiae)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Saccharomyces cerevisiae)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Saccharomyces cerevisiae)
        
        Clathrin Triskelion [cytosol] (Saccharomyces cerevisiae)
        
        CHC1 [cytosol] (Saccharomyces cerevisiae)

External Reference Information

External Reference

UniProt:P22137

Gene Names

CHC1

Reference Genes

BioGPS Gene:852666 CHC1

ENSEMBL:YGL206C

KEGG Gene (Saccharomyces cerevisiae (strain RM11-1a)):YGL206C CHC1

Monarch:852666 CHC1

NCBI Gene:852666 CHC1

SGD:YGL206C

Reference Transcript

RefSeq:NM_001181071.1 CHC1

Other Identifiers

1774993_at

5219_at

852666

GO:0003674

GO:0005198

GO:0005515

GO:0005575

GO:0005737

GO:0005794

GO:0005829

GO:0005886

GO:0006886

GO:0006895

GO:0006897

GO:0008150

GO:0012505

GO:0015031

GO:0016020

GO:0016192

GO:0030125

GO:0030130

GO:0030132

GO:0031410

GO:0032051

GO:0048193

GO:0048268

GO:0071439

Participates

as a component of

Clathrin Triskelion [cytosol] (Saccharomyces cerevisiae)

Other forms of this molecule

CHC1 [cytosol]

CHC1 [trans-Golgi network membrane]

CHC1 [lysosomal membrane]

CHC1 [endolysosome membrane]

CHC1 [plasma membrane]

Inferred From

CLTC [cytosol] (Homo sapiens)

Clathrin heavy chain [cytosol] (Homo sapiens)

CLTC-1 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_011309.1

PRO

P22137

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q12271	2	INP53 [cytosol] (R-SCE-1604634) INP53 [cytosol] (R-SCE-1806193-4)	0.547	2
UniProt:P10592	6	SSA2 [secretory granule lumen] (R-SCE-6801530) SSA2 [cytosol] (R-SCE-264476) SSA2 [extracellular region] (R-SCE-6805936) SSA2 [ficolin-1-rich granule lumen] (R-SCE-6801494) SSA2 [nucleoplasm] (R-SCE-5082380) SSA2 [nucleoplasm] (R-SCE-8932217)	0.527	2

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