Reactome | RPH1 [nucleoplasm]

RPH1 [nucleoplasm]

Stable Identifier

R-SCE-351646

Type

Protein [EntityWithAccessionedSequence]

Species

Saccharomyces cerevisiae

Compartment

nucleoplasm

Synonyms

KDM4A, P39956

Locations in the PathwayBrowser

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DNA Repair (Saccharomyces cerevisiae)

- DNA Double-Strand Break Repair (Saccharomyces cerevisiae)
  - DNA Double Strand Break Response (Saccharomyces cerevisiae)
    - Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Saccharomyces cerevisiae)
      - ATM phosphorylates HERC2 (Saccharomyces cerevisiae)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:HERC2:PIAS4 [nucleoplasm] (Saccharomyces cerevisiae)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+ [nucleoplasm] (Saccharomyces cerevisiae)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Saccharomyces cerevisiae)
        
        KDM4A,B [nucleoplasm] (Saccharomyces cerevisiae)
        
        Homologues of KDM4A [nucleoplasm] (Saccharomyces cerevisiae)
        
        RPH1 [nucleoplasm] (Saccharomyces cerevisiae)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:p-T4827-HERC2:PIAS4 [nucleoplasm] (Saccharomyces cerevisiae)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+ [nucleoplasm] (Saccharomyces cerevisiae)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Saccharomyces cerevisiae)
        
        KDM4A,B [nucleoplasm] (Saccharomyces cerevisiae)
        
        Homologues of KDM4A [nucleoplasm] (Saccharomyces cerevisiae)
        
        RPH1 [nucleoplasm] (Saccharomyces cerevisiae)
      - HERC2 facilitates UBE2N:UBE2V2 binding to RNF8 (Saccharomyces cerevisiae)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:PIAS4 [nucleoplasm] (Saccharomyces cerevisiae)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Saccharomyces cerevisiae)
        
        KDM4A,B [nucleoplasm] (Saccharomyces cerevisiae)
        
        Homologues of KDM4A [nucleoplasm] (Saccharomyces cerevisiae)
        
        RPH1 [nucleoplasm] (Saccharomyces cerevisiae)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:PIAS4 [nucleoplasm] (Saccharomyces cerevisiae)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Saccharomyces cerevisiae)
        
        KDM4A,B [nucleoplasm] (Saccharomyces cerevisiae)
        
        Homologues of KDM4A [nucleoplasm] (Saccharomyces cerevisiae)
        
        RPH1 [nucleoplasm] (Saccharomyces cerevisiae)
      - KDM4A,B bind H4K20Me2 (Saccharomyces cerevisiae)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Saccharomyces cerevisiae)
        
        KDM4A,B [nucleoplasm] (Saccharomyces cerevisiae)
        
        Homologues of KDM4A [nucleoplasm] (Saccharomyces cerevisiae)
        
        RPH1 [nucleoplasm] (Saccharomyces cerevisiae)
        
        KDM4A,B [nucleoplasm] (Saccharomyces cerevisiae)
        
        Homologues of KDM4A [nucleoplasm] (Saccharomyces cerevisiae)
        
        RPH1 [nucleoplasm] (Saccharomyces cerevisiae)
      - PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs (Saccharomyces cerevisiae)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:PIAS4 [nucleoplasm] (Saccharomyces cerevisiae)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Saccharomyces cerevisiae)
        
        KDM4A,B [nucleoplasm] (Saccharomyces cerevisiae)
        
        Homologues of KDM4A [nucleoplasm] (Saccharomyces cerevisiae)
        
        RPH1 [nucleoplasm] (Saccharomyces cerevisiae)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:p-T4827-HERC2:PIAS4 [nucleoplasm] (Saccharomyces cerevisiae)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+ [nucleoplasm] (Saccharomyces cerevisiae)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Saccharomyces cerevisiae)
        
        KDM4A,B [nucleoplasm] (Saccharomyces cerevisiae)
        
        Homologues of KDM4A [nucleoplasm] (Saccharomyces cerevisiae)
        
        RPH1 [nucleoplasm] (Saccharomyces cerevisiae)
      - RNF8 and RNF168 ubiquitinate H2AFX (Saccharomyces cerevisiae)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Saccharomyces cerevisiae)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Saccharomyces cerevisiae)
        
        KDM4A,B [nucleoplasm] (Saccharomyces cerevisiae)
        
        Homologues of KDM4A [nucleoplasm] (Saccharomyces cerevisiae)
        
        RPH1 [nucleoplasm] (Saccharomyces cerevisiae)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Saccharomyces cerevisiae)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:PIAS4 [nucleoplasm] (Saccharomyces cerevisiae)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Saccharomyces cerevisiae)
        
        KDM4A,B [nucleoplasm] (Saccharomyces cerevisiae)
        
        Homologues of KDM4A [nucleoplasm] (Saccharomyces cerevisiae)
        
        RPH1 [nucleoplasm] (Saccharomyces cerevisiae)
      - RNF8 and RNF168 ubiquitinate KDM4A,B (Saccharomyces cerevisiae)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Saccharomyces cerevisiae)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Saccharomyces cerevisiae)
        
        KDM4A,B [nucleoplasm] (Saccharomyces cerevisiae)
        
        Homologues of KDM4A [nucleoplasm] (Saccharomyces cerevisiae)
        
        RPH1 [nucleoplasm] (Saccharomyces cerevisiae)
      - RNF8 binds phosphorylated MDC1 at DNA DSBs (Saccharomyces cerevisiae)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Saccharomyces cerevisiae)
        
        KDM4A,B [nucleoplasm] (Saccharomyces cerevisiae)
        
        Homologues of KDM4A [nucleoplasm] (Saccharomyces cerevisiae)
        
        RPH1 [nucleoplasm] (Saccharomyces cerevisiae)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+ [nucleoplasm] (Saccharomyces cerevisiae)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Saccharomyces cerevisiae)
        
        KDM4A,B [nucleoplasm] (Saccharomyces cerevisiae)
        
        Homologues of KDM4A [nucleoplasm] (Saccharomyces cerevisiae)
        
        RPH1 [nucleoplasm] (Saccharomyces cerevisiae)

External Reference Information

External Reference

UniProt:P39956

Gene Names

RPH1

Reference Genes

BioGPS Gene:856916 RPH1

ENSEMBL:YER169W

KEGG Gene (Saccharomyces cerevisiae (strain RM11-1a)):YER169W RPH1

Monarch:856916 RPH1

NCBI Gene:856916 RPH1

SGD:YER169W

Reference Transcript

RefSeq:NM_001179059.1 RPH1

Other Identifiers

1773383_at

5562_at

856916

GO:0000122

GO:0000785

GO:0001078

GO:0001227

GO:0003674

GO:0003677

GO:0003700

GO:0003824

GO:0005575

GO:0005634

GO:0005694

GO:0006325

GO:0006338

GO:0006351

GO:0006354

GO:0006366

GO:0008150

GO:0008270

GO:0010468

GO:0010507

GO:0016491

GO:0016570

GO:0016577

GO:0032454

GO:0032968

GO:0043167

GO:0043565

GO:0046872

GO:0051864

Participates

as a member of

Homologues of KDM4A [nucleoplasm] (Saccharomyces cerevisiae)

Other forms of this molecule

RPH1 [nucleoplasm]

Inferred From

KDM4A [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_011096.1

PRO

P39956

PDB

3OPW, 3OPT

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