Reactome | FBXW7 [cytosol]

FBXW7 [cytosol]

Stable Identifier

R-SCE-391304

Type

Protein [EntityWithAccessionedSequence]

Species

Saccharomyces cerevisiae

Compartment

cytosol

Synonyms

P36037

Locations in the PathwayBrowser

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Immune System (Saccharomyces cerevisiae)

- Adaptive Immune System (Saccharomyces cerevisiae)
  - Class I MHC mediated antigen processing & presentation (Saccharomyces cerevisiae)
    - Antigen processing: Ubiquitination & Proteasome degradation (Saccharomyces cerevisiae)
      - Release of E3 from polyubiquitinated substrate (Saccharomyces cerevisiae)
        
        E3 ligases in proteasomal degradation [cytosol] (Saccharomyces cerevisiae)
        
        SCF E3 ubiquitin ligase [cytosol] (Saccharomyces cerevisiae)
        
        F-box protein [cytosol] (Saccharomyces cerevisiae)
        
        FBXW7 [cytosol] (Saccharomyces cerevisiae)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Saccharomyces cerevisiae)
        
        E3 ligases in proteasomal degradation [cytosol] (Saccharomyces cerevisiae)
        
        SCF E3 ubiquitin ligase [cytosol] (Saccharomyces cerevisiae)
        
        F-box protein [cytosol] (Saccharomyces cerevisiae)
        
        FBXW7 [cytosol] (Saccharomyces cerevisiae)
      - Transfer of Ub from E2 to substrate and release of E2 (Saccharomyces cerevisiae)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Saccharomyces cerevisiae)
        
        E3 ligases in proteasomal degradation [cytosol] (Saccharomyces cerevisiae)
        
        SCF E3 ubiquitin ligase [cytosol] (Saccharomyces cerevisiae)
        
        F-box protein [cytosol] (Saccharomyces cerevisiae)
        
        FBXW7 [cytosol] (Saccharomyces cerevisiae)
        
        E3 ligases in proteasomal degradation [cytosol] (Saccharomyces cerevisiae)
        
        SCF E3 ubiquitin ligase [cytosol] (Saccharomyces cerevisiae)
        
        F-box protein [cytosol] (Saccharomyces cerevisiae)
        
        FBXW7 [cytosol] (Saccharomyces cerevisiae)
        
        E3:Ub:substrate [cytosol] (Saccharomyces cerevisiae)
        
        E3 ligases in proteasomal degradation [cytosol] (Saccharomyces cerevisiae)
        
        SCF E3 ubiquitin ligase [cytosol] (Saccharomyces cerevisiae)
        
        F-box protein [cytosol] (Saccharomyces cerevisiae)
        
        FBXW7 [cytosol] (Saccharomyces cerevisiae)

Metabolism of proteins (Saccharomyces cerevisiae)

- Post-translational protein modification (Saccharomyces cerevisiae)
  - Neddylation (Saccharomyces cerevisiae)
    - AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Saccharomyces cerevisiae)
      - NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Saccharomyces cerevisiae)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Saccharomyces cerevisiae)
        
        SCF E3 ubiquitin ligase [cytosol] (Saccharomyces cerevisiae)
        
        F-box protein [cytosol] (Saccharomyces cerevisiae)
        
        FBXW7 [cytosol] (Saccharomyces cerevisiae)
      - NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Saccharomyces cerevisiae)
        
        NEDD8-CRL1 E3 ligase complex [cytosol] (Saccharomyces cerevisiae)
        
        F-box protein [cytosol] (Saccharomyces cerevisiae)
        
        FBXW7 [cytosol] (Saccharomyces cerevisiae)

External Reference Information

External Reference

UniProt:P36037

Reference Genes

BioGPS Gene:853667

ENSEMBL:YKL213C

KEGG Gene (Saccharomyces cerevisiae (strain RM11-1a)):YKL213C

Monarch:853667

NCBI Gene:853667

SGD:YKL213C

Reference Transcript

RefSeq:NM_001179778.1

Other Identifiers

3GAE

3L3F

3ODT

3PSP

3PST

4932.YKL213C

AAA82258.1

CAA53560.1

CAA82058.1

DAA08956.1

EntrezGene:853667

EntrezGene:DOA1

GO:0003674

GO:0005515

GO:0005575

GO:0005634

GO:0005737

GO:0006281

GO:0006303

GO:0006974

GO:0008150

GO:0010992

GO:0032182

GO:0034517

GO:0043130

GO:0043161

GO:0051603

GO:0072671

IPR001680

IPR011989

IPR013535

IPR015155

IPR015943

IPR016024

IPR017986

IPR020472

IPR033510

IPR036322

IPR038122

NM_001179778.1

NP_012709.1

PF00400

PF08324

PF09070

PR00320

SM00320

UPI0000053183

YKL213C

YKL213C_mRNA

Participant Of

hasMember

F-box protein [cytosol]

Inferred From

FBXW7 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_012709.1

PRO

P36037

PDB

3PST, 3GAE, 3PSP, 3L3F, 3ODT

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P25694	7	VCP [ficolin-1-rich granule lumen] (R-SCE-6800425) VCP [cytosol] (R-SCE-1181251) VCP [extracellular region] (R-SCE-6806191) VCP [secretory granule lumen] (R-SCE-6801039) VCP [azurophil granule lumen] (R-SCE-6800438) VCP [nucleoplasm] (R-SCE-5643745) Me3K315-VCP [cytosol] (R-SCE-8932209)	0.84	26
UniProt:P38753	1	STAM [cytosol] (R-SCE-182925)	0.681	3
UniProt:Q01477	3	USP37 [nucleoplasm] (R-SCE-5697000) USP10 [nucleoplasm] (R-SCE-3222218) USP10 [cytosol] (R-SCE-6782974)	0.632	4