Reactome | SIRT1 [nucleoplasm]

SIRT1 [nucleoplasm]

Stable Identifier

R-SCE-427531

Type

Protein [EntityWithAccessionedSequence]

Species

Saccharomyces cerevisiae

Compartment

nucleoplasm

Synonyms

P06700

Locations in the PathwayBrowser for interactor UniProt:Q00684

Expand all

External Reference Information

External Reference

UniProt:P06700

Reference Genes

BioGPS Gene:851520

ENSEMBL:YDL042C

KEGG Gene (Saccharomyces cerevisiae (strain YJM789)):YDL042C

Monarch:851520

NCBI Gene:851520

SGD:YDL042C

Reference Transcript

RefSeq:NM_001180101.1

Other Identifiers

1779931_at

6510_at

851520

GO:0000183

GO:0000781

GO:0000784

GO:0000792

GO:0001300

GO:0001302

GO:0003674

GO:0003682

GO:0005515

GO:0005575

GO:0005634

GO:0005677

GO:0005694

GO:0005720

GO:0005724

GO:0005730

GO:0006260

GO:0006281

GO:0006303

GO:0006310

GO:0006325

GO:0006333

GO:0006348

GO:0006351

GO:0006974

GO:0006997

GO:0007059

GO:0007062

GO:0008150

GO:0008156

GO:0008270

GO:0016740

GO:0016787

GO:0017136

GO:0030466

GO:0030869

GO:0031047

GO:0031491

GO:0031507

GO:0031509

GO:0032041

GO:0032200

GO:0033558

GO:0034398

GO:0043167

GO:0045910

GO:0046872

GO:0046969

GO:0046970

GO:0051052

GO:0070403

GO:0097695

GO:0097752

GO:1904524

Participates

as an output of

SIRT1 deacetylates HSF1 (Saccharomyces cerevisiae)

as an input of

SIRT1 binds to HSF1 (Saccharomyces cerevisiae)

as a component of

SIRT1:HSP70:DNAJB1:Ac-K80-HSF1:target gene [nucleoplasm] (Saccharomyces cerevisiae)

Inferred From

SIRT1 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_010242.1

IntEnz

2.3.1.286

ZINC - Substances

SIR2_YEAST

ZINC target

P06700

PRO

P06700

ZINC - Predictions - Purchasable

SIR2_YEAST

PDB

2HJH, 4IAO

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P47035 NET1			0.877	16
UniProt:P11978 SIR4			0.877	22
UniProt:Q00684	3	CDC14 [cytosol] (R-SCE-174094) CDC14 [nucleoplasm] (R-SCE-5692694) CDC14 [nucleoplasm] (R-SCE-3214897)	0.758	5
UniProt:Q02208 TOF2			0.641	3
UniProt:P06701 SIR3			0.564	2
UniProt:O13329 FOB1			0.564	3
UniProt:P02829	11	HSP90AA1 [secretory granule lumen] (R-SCE-6801515) HSP90AB1 [secretory granule lumen] (R-SCE-6801477) HSP90AB1 [extracellular region] (R-SCE-6806463) HSP90AA1 [extracellular region] (R-SCE-3221946) HSP90AA1 [ficolin-1-rich granule lumen] (R-SCE-6801470) HSP90AB1 [ficolin-1-rich granule lumen] (R-SCE-6801491) HSP90AA1 [plasma membrane] (R-SCE-534996) HSP90AB1 [cytosol] (R-SCE-419617) HSP90AA1 [nucleoplasm] (R-SCE-5082401) HSP90AB1 [nucleoplasm] (R-SCE-5082399) HSP90AA1 [cytosol] (R-SCE-192864)	0.547	2
UniProt:P10592	8	SSA2 [cytosol] (R-SCE-264476) SSA2 [nucleoplasm] (R-SCE-5082380) SSA2 [ficolin-1-rich granule lumen] (R-SCE-6801494) SSA2 [extracellular region] (R-SCE-6805936) SSA2 [secretory granule lumen] (R-SCE-6801530) SSA2 [nucleoplasm] (R-SCE-912480-3) SSA2 [cytosol] (R-SCE-3371408-3) SSA2 [nucleoplasm] (R-SCE-8932217)	0.527	2
UniProt:P11484	2	HSPA2 [nucleoplasm] (R-SCE-912480-4) HSPA2 [cytosol] (R-SCE-3371408-4)	0.527	2
UniProt:P32589 HSP7F			0.527	2
UniProt:P22146 GAS1			0.508	2

Cite Us!