Reactome | HHT2 [nucleoplasm]

HHT2 [nucleoplasm]

Stable Identifier

R-SCE-427744

Type

Protein [EntityWithAccessionedSequence]

Species

Saccharomyces cerevisiae

Compartment

nucleoplasm

Synonyms

Me3K-10-HIST2H3A, P61830

Locations in the PathwayBrowser

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Signal Transduction (Saccharomyces cerevisiae)

- Signaling by Nuclear Receptors (Saccharomyces cerevisiae)
  - ESR-mediated signaling (Saccharomyces cerevisiae)
    - Estrogen-dependent gene expression (Saccharomyces cerevisiae)
      - KDM4B demethylates H3K9me3 on estrogen-responsive target enhancers (Saccharomyces cerevisiae)
        
        KDM4B-regulated genes:H3K9me3 nucleosome:ESR1:ESTG:KDM4B [nucleoplasm] (Saccharomyces cerevisiae)
        
        KDM4B-regulated genes:H3K9me3 nucleosome [nucleoplasm] (Saccharomyces cerevisiae)
        
        Nucleosome with H3K9me3 [nucleoplasm] (Saccharomyces cerevisiae)
        
        HHT2 [nucleoplasm] (Saccharomyces cerevisiae)
- Signaling by Rho GTPases (Saccharomyces cerevisiae)
  - RHO GTPase Effectors (Saccharomyces cerevisiae)
    - RHO GTPases activate PKNs (Saccharomyces cerevisiae)
      - Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 (Saccharomyces cerevisiae)
        
        PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters (Saccharomyces cerevisiae)
        
        p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with Me3K-10-H3 [nucleoplasm] (Saccharomyces cerevisiae)
        
        KLK2,3 Gene:Nucleosome with Me3K-10-H3 [nucleoplasm] (Saccharomyces cerevisiae)
        
        Nucleosome with H3K9me3 [nucleoplasm] (Saccharomyces cerevisiae)
        
        HHT2 [nucleoplasm] (Saccharomyces cerevisiae)

External Reference Information

External Reference

UniProt:P61830

Gene Names

HHT2

Reference Genes

BioGPS Gene:852295 HHT2

BioGPS Gene:855700 HHT2

ENSEMBL:YBR010W

KEGG Gene (Saccharomyces cerevisiae):YBR010W HHT2

KEGG Gene (Saccharomyces cerevisiae):YNL031C HHT2

Monarch:852295 HHT2

Monarch:855700 HHT2

NCBI Gene:852295 HHT2

NCBI Gene:855700 HHT2

SGD:YBR010W

Reference Transcript

Other Identifiers

1773019_at

1775541_at

7368_i_at

7369_s_at

852295

855700

8910_at

GO:0000786

GO:0000788

GO:0003674

GO:0003677

GO:0003682

GO:0005575

GO:0005634

GO:0005694

GO:0006281

GO:0006325

GO:0006333

GO:0006334

GO:0006974

GO:0008150

GO:0009303

GO:0031298

GO:0031492

GO:0043505

GO:0043934

GO:0043935

GO:0046982

GO:0051321

GO:0070911

Participant Of

hasComponent

Nucleosome with H3K9me3 [nucleoplasm]

Other forms of this molecule

HHT2 [nucleoplasm]

phospho-HHT2 [nucleoplasm]

HHT2 [nucleoplasm]

Inferred From

Me3K-10-HIST2H3A [nucleoplasm] (Homo sapiens)

H3K9me3 [nucleoplasm] (Homo sapiens)

Modified Residues

Name

N6,N6,N6-trimethyl-L-lysine at 10 (in Homo sapiens)

Coordinate

PsiMod Name

N6,N6,N6-trimethyl-L-lysine [MOD:00083]

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to N6,N6,N6-trimethyl-L-lysine.

Cross References

RefSeq

NP_014367.1, NP_009564.1

Target Pathogen

5b2801b2be737e35a6dea9b5, 5b2801b3be737e35a6df1873, 5b2801b2be737e35a6dea8d6, 5b354852be737e166372e85a, 5b354852be737e166372eaa9

PRO

P61830

PDB

1M1D, 5IOK, 2IDC, 6KMJ, 5ZBB, 5D7E, 2RSN, 4KUD, 2H2G, 1PU9, 2RNW, 4PSX, 2RNX, 1PUA, 2JMJ, 3MP1, 6GEJ, 3Q33, 1PEG, 3MP6, 5ZBA, 1ID3, 6J2P, 2CNX, 1QSN, 4JJN, 6GEN

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P02309	14	HHF2 [nucleoplasm] (R-SCE-212078) HHF2 [nucleoplasm] (R-SCE-4570518) HHF2 [nucleoplasm] (R-SCE-4568744) HHF2 [nucleoplasm] (R-SCE-4568748) HHF2 [nucleoplasm] (R-SCE-427469) HHF2 [nucleoplasm] (R-SCE-4568758) HHF2 [nucleoplasm] (R-SCE-5229015) HHF2 [nucleoplasm] (R-SCE-4754243) HHF2 [nucleoplasm] (R-SCE-4754240) HHF2 [nucleoplasm] (R-SCE-5651656) HHF2 [nucleoplasm] (R-SCE-3451124) HHF2 [nucleoplasm] (R-SCE-2172676) HHF2 [nucleoplasm] (R-SCE-181902) HHF2 [nucleoplasm] (R-SCE-5651652)	0.912	69
UniProt:P32447	1	ASF1 [nucleoplasm] (R-SCE-417169)	0.752	36
UniProt:Q04636	1	POB3 [nucleoplasm] (R-SCE-65105)	0.688	32
UniProt:P32558	1	SPT16 [nucleoplasm] (R-SCE-112415)	0.564	35