Reactome | HDA1 [nucleoplasm]

HDA1 [nucleoplasm]

Stable Identifier

R-SCE-4616016

Type

Protein [EntityWithAccessionedSequence]

Species

Saccharomyces cerevisiae

Compartment

nucleoplasm

Synonyms

SUMO1-K559-HDAC4, P53973

Locations in the PathwayBrowser

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Metabolism of proteins (Saccharomyces cerevisiae)

- Post-translational protein modification (Saccharomyces cerevisiae)
  - SUMOylation (Saccharomyces cerevisiae)
    - SUMO E3 ligases SUMOylate target proteins (Saccharomyces cerevisiae)
      - SUMOylation of chromatin organization proteins (Saccharomyces cerevisiae)
        
        RANBP2 SUMOylates HDAC4 with SUMO1 (Saccharomyces cerevisiae)
        
        SUMO1:HDAC4 [nucleoplasm] (Saccharomyces cerevisiae)
        
        HDA1 [nucleoplasm] (Saccharomyces cerevisiae)

External Reference Information

External Reference

UniProt:P53973

Gene Names

HDA1

Reference Genes

BioGPS Gene:855710 HDA1

ENSEMBL:YNL021W

KEGG Gene (Saccharomyces cerevisiae (strain YJM789)):YNL021W HDA1

Monarch:855710 HDA1

NCBI Gene:855710 HDA1

SGD:YNL021W

Reference Transcript

RefSeq:NM_001182860.1 HDA1

Other Identifiers

1778360_at

855710

8874_at

GO:0000122

GO:0001308

GO:0003674

GO:0003682

GO:0005575

GO:0005634

GO:0005694

GO:0006325

GO:0006351

GO:0006366

GO:0008150

GO:0010621

GO:0010978

GO:0016570

GO:0016575

GO:0016787

GO:0031047

GO:0031938

GO:0032041

GO:0033043

GO:0042802

GO:0045944

GO:0070823

Participant Of

hasComponent

SUMO1:HDAC4 [nucleoplasm]

Other forms of this molecule

HDA1 [nucleoplasm]

HDA1 [cytosol]

Inferred From

SUMO1-K559-HDAC4 [nucleoplasm] (Homo sapiens)

Modified Residues

Name

Inter-chain Crosslink via sumoylated lysine at 559 and 97 (in Homo sapiens)

Coordinate

559

Modification

glycyl group

PsiMod Name

sumoylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.

Cross References

RefSeq

NP_014377.1

IntEnz

3.5.1.98

PRO

P53973

PDB

5J8J

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q06629	3	HDA2 [cytosol] (R-SCE-561192) HDA2 [cytosol] (R-SCE-5690853) HDA2 [cytosol] (R-SCE-451661)	0.827	16
UniProt:Q06623 HDA3			0.827	13
UniProt:P53973	4	HDA1 [nucleoplasm] (R-SCE-351579) HDA1 [nucleoplasm] (R-SCE-4616016) HDA1 [nucleoplasm] (R-SCE-351581) HDA1 [cytosol] (R-SCE-5324660)	0.737	4
UniProt:P42944	2	GZF3 [nucleoplasm] (R-SCE-996768-2) GZF3 [nucleoplasm] (R-SCE-452902-2)	0.553	2
UniProt:P10592	23	SSA2 [nucleoplasm] (R-SCE-5082380-3) SSA2 [cytosol] (R-SCE-264476-3) SSA2 [secretory granule lumen] (R-SCE-6801530-3) SSA2 [secretory granule lumen] (R-SCE-6801472-3) SSA2 [extracellular region] (R-SCE-6806500-3) SSA2 [extracellular region] (R-SCE-6805936-3) SSA2 [ficolin-1-rich granule lumen] (R-SCE-6801512-3) SSA2 [ficolin-1-rich granule lumen] (R-SCE-6801496-3) SSA2 [ficolin-1-rich granule lumen] (R-SCE-6801494-3) SSA2 [extracellular region] (R-SCE-6805872-3) SSA2 [nucleoplasm] (R-SCE-912480-3) SSA2 [nucleoplasm] (R-SCE-5082367-3) SSA2 [nucleoplasm] (R-SCE-6792605-3) SSA2 [nucleoplasm] (R-SCE-5252082-3) SSA2 [nucleoplasm] (R-SCE-5252088-3) SSA2 [nucleoplasm] (R-SCE-5252047-3) SSA2 [cytosol] (R-SCE-3371410-3) SSA2 [cytosol] (R-SCE-5251948-3) SSA2 [cytosol] (R-SCE-3371408-3) SSA2 [cytosol] (R-SCE-3371521-3) SSA2 [cytosol] (R-SCE-5251954-3) SSA2 [cytosol] (R-SCE-6792602-3) SSA2 [nucleoplasm] (R-SCE-8932217-3)	0.527	2

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