Reactome | SUMO1-K-TOP2A [nucleoplasm]

SUMO1-K-TOP2A [nucleoplasm]

Stable Identifier

R-SCE-4641367

Type

Protein [EntityWithAccessionedSequence]

Species

Saccharomyces cerevisiae

Compartment

nucleoplasm

Synonyms

P06786

Locations in the PathwayBrowser

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Metabolism of proteins (Saccharomyces cerevisiae)

- Post-translational protein modification (Saccharomyces cerevisiae)
  - SUMOylation (Saccharomyces cerevisiae)
    - SUMO E3 ligases SUMOylate target proteins (Saccharomyces cerevisiae)
      - SUMOylation of DNA replication proteins (Saccharomyces cerevisiae)
        
        SUMOylation of TOP2A with SUMO1 (Saccharomyces cerevisiae)
        
        SUMO1:TOP2A [nucleoplasm] (Saccharomyces cerevisiae)
        
        SUMO1-K-TOP2A [nucleoplasm] (Saccharomyces cerevisiae)

External Reference Information

External Reference

UniProt:P06786

Reference Genes

BioGPS Gene:855636

dbSNP Gene:855636

ENSEMBL:YNL088W

KEGG Gene (Saccharomyces cerevisiae (strain RM11-1a)):YNL088W

Monarch:855636

NCBI Gene:855636

SGD:YNL088W

Reference Transcript

RefSeq:NM_001182926.3

Other Identifiers

1779900_at

1BGW

1BJT

1PVG

1QZR

2RGR

3L4J

3L4K

4932.YNL088W

4GFH

8944_at

AAB36610.1

AAM00518.1

AAM00530.1

AAM00536.1

CAA61422.1

CAA95964.1

DAA10457.1

EntrezGene:855636

EntrezGene:TOP2

GO:0000019

GO:0000278

GO:0000712

GO:0000795

GO:0000819

GO:0003674

GO:0003677

GO:0003918

GO:0005524

GO:0005575

GO:0005634

GO:0005694

GO:0006260

GO:0006265

GO:0006271

GO:0006310

GO:0006325

GO:0006333

GO:0007059

GO:0007131

GO:0008150

GO:0016787

GO:0016853

GO:0016887

GO:0031055

GO:0042802

GO:0043167

GO:0044774

GO:0046872

GO:0048285

GO:0051052

GO:0051321

GO:0051726

GO:0097046

GO:0097047

IPR001154

IPR001241

IPR002205

IPR003594

IPR006171

IPR013506

IPR013759

IPR013760

IPR014721

IPR018522

IPR020568

IPR031660

IPR034157

IPR036890

NM_001182926.3

NP_014311.3

PF00204

PF00521

PF01751

PF02518

PF16898

PR00418

PR01158

SM00387

SM00433

SM00434

UPI00000010F4

YNL088W

YNL088W_mRNA

Participant Of

hasComponent

SUMO1:TOP2A [nucleoplasm]

Other forms of this molecule

SUMO1-K-TOP2B [nucleoplasm]

TOP2B [nucleoplasm]

TOP2A [nucleoplasm]

Inferred From

SUMO1-K-TOP2A [nucleoplasm] (Homo sapiens)

Modified Residues

Name

UniProt:P06786 glycyl group sumoylated lysine

PsiMod Name

sumoylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.

Cross References

RefSeq

NP_014311.3

PRO

P06786

PDB

2RGR, 4GFH, 1QZR, 3L4J, 1BGW, 3L4K, 1PVG, 1BJT

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P06786	4	TOP2B [nucleoplasm] (R-SCE-4641359) SUMO1-K-TOP2B [nucleoplasm] (R-SCE-4641297) SUMO1-K-TOP2A [nucleoplasm] (R-SCE-4641367) TOP2A [nucleoplasm] (R-SCE-1362276)	0.825	5
UniProt:Q12159	2	ALYREF [cytosol] (R-SCE-158482) ALYREF [nucleoplasm] (R-SCE-156649)	0.564	6
UniProt:P10591	23	HSPA6 [ficolin-1-rich granule lumen] (R-SCE-6801512-2) HSPA8 [cytosol] (R-SCE-264476-2) HSPA1A [ficolin-1-rich granule lumen] (R-SCE-6801496-2) HSPA8 [ficolin-1-rich granule lumen] (R-SCE-6801494-2) HSPA1A [extracellular region] (R-SCE-6805872-2) HSPA6 [extracellular region] (R-SCE-6806500-2) HSPA8 [extracellular region] (R-SCE-6805936-2) HSPA8 [secretory granule lumen] (R-SCE-6801530-2) HSPA6 [secretory granule lumen] (R-SCE-6801472-2) HSPA8 [nucleoplasm] (R-SCE-5082380-2) HSPA2 [nucleoplasm] (R-SCE-912480-2) HSPA1L [nucleoplasm] (R-SCE-5082367-2) HSPA1A [nucleoplasm] (R-SCE-6792605-2) HSPA6 [nucleoplasm] (R-SCE-5252088-2) HSPA13 [nucleoplasm] (R-SCE-5252009-2) HSPA7 [nucleoplasm] (R-SCE-5252047-2) HSPA1L [cytosol] (R-SCE-3371410-2) HSPA2 [cytosol] (R-SCE-3371408-2) HSPA13 [cytosol] (R-SCE-5251981-2) HSPA6 [cytosol] (R-SCE-3371521-2) HSPA7 [cytosol] (R-SCE-5251954-2) HSPA1A [cytosol] (R-SCE-6792602-2) Me3K561-HSPA8 [nucleoplasm] (R-SCE-8932217-2)	0.527	2
UniProt:P11484	23	HSPA6 [ficolin-1-rich granule lumen] (R-SCE-6801512-4) HSPA8 [cytosol] (R-SCE-264476-4) HSPA1A [ficolin-1-rich granule lumen] (R-SCE-6801496-4) HSPA8 [ficolin-1-rich granule lumen] (R-SCE-6801494-4) HSPA1A [extracellular region] (R-SCE-6805872-4) HSPA6 [extracellular region] (R-SCE-6806500-4) HSPA8 [extracellular region] (R-SCE-6805936-4) HSPA8 [secretory granule lumen] (R-SCE-6801530-4) HSPA6 [secretory granule lumen] (R-SCE-6801472-4) HSPA8 [nucleoplasm] (R-SCE-5082380-4) HSPA2 [nucleoplasm] (R-SCE-912480-4) HSPA1L [nucleoplasm] (R-SCE-5082367-4) HSPA1A [nucleoplasm] (R-SCE-6792605-4) HSPA6 [nucleoplasm] (R-SCE-5252088-4) HSPA13 [nucleoplasm] (R-SCE-5252009-4) HSPA7 [nucleoplasm] (R-SCE-5252047-4) HSPA1L [cytosol] (R-SCE-3371410-4) HSPA2 [cytosol] (R-SCE-3371408-4) HSPA13 [cytosol] (R-SCE-5251981-4) HSPA6 [cytosol] (R-SCE-3371521-4) HSPA7 [cytosol] (R-SCE-5251954-4) HSPA1A [cytosol] (R-SCE-6792602-4) Me3K561-HSPA8 [nucleoplasm] (R-SCE-8932217-4)	0.527	3
UniProt:P24583	41	PRKCD(330-676) [extracellular region] (R-SCE-6806199) PRKCH [cytosol] (R-SCE-58208) PRKCD(1-329) [extracellular region] (R-SCE-6806226) PRKCD(1-329) [azurophil granule lumen] (R-SCE-6799219) PRKCD(330-676) [azurophil granule lumen] (R-SCE-6799221) phospho-p-Y90,T219,T538,S676,S695-PRKCQ [plasma membrane] (R-SCE-2685606) PRKCQ [plasma membrane] (R-SCE-202346) phospho-p-Y90-PRKCQ [plasma membrane] (R-SCE-202395) phospho-p-Y90,T538,S676,S695-PRKCQ [plasma membrane] (R-SCE-202152) phospho-pS, p-T410-PRKCZ [cytosol] (R-SCE-9632824) PRKCB [plasma membrane] (R-SCE-156467) PRKCA [plasma membrane] (R-SCE-156469) PRKCG [cytosol] (R-SCE-58204) PRKCE [cytosol] (R-SCE-58202) phospho-p-T507,S645,S664-PRKCD(1-676) [plasma membrane] (R-SCE-198294) phospho-p-T566,T710,S729-PRKCE [plasma membrane] (R-SCE-198260) PRKCD(330-676) [cytosol] (R-SCE-212551) PRKCD(1-329) [cytosol] (R-SCE-212547) PRKCQ(1-354) [cytosol] (R-SCE-212526) PRKCQ(355-706) [cytosol] (R-SCE-212514) phospho-p-T774-PKN1 [cytosol] (R-SCE-5623651) PKN3 [cytosol] (R-SCE-5623611) PKN1 [cytosol] (R-SCE-5623613) PKN2 [cytosol] (R-SCE-5623612) phospho-p-T718-PKN3 [cytosol] (R-SCE-5623654) phospho-p-T816-PKN2 [cytosol] (R-SCE-5623652) PRKCA [cytosol] (R-SCE-58196) phospho-p-T500,T642,S661-PRKCB [nucleoplasm] (R-SCE-5223294) phospho-p-T497,T638,S657-PRKCA [nucleoplasm] (R-SCE-5223292) phospho-p-T497-PRKCA [cytosol] (R-SCE-5218731) phospho-p-T507-PRKCD [cytosol] (R-SCE-5218746) phospho-p-T500-PRKCB [cytosol] (R-SCE-5218728) phospho-p-T410-PRKCZ [cytosol] (R-SCE-437181) phospho-p-T507,S645,S664-PRKCD [cytosol] (R-SCE-5218734) phospho-p-T497,T638,S657-PRKCA [cytosol] (R-SCE-4332337) phospho-p-T410,T563-PRKCZ [cytosol] (R-SCE-5218698) phospho-p-T500,T642,S661-PRKCB [cytosol] (R-SCE-5218706) PRKCB [cytosol] (R-SCE-58198) PRKCD [cytosol] (R-SCE-58200) PRKCZ [cytosol] (R-SCE-58218) PRKCQ [cytosol] (R-SCE-58216)	0.508	2