Reactome | TOP2 [nucleoplasm]

TOP2 [nucleoplasm]

Stable Identifier

R-SCE-4641367

Type

Protein [EntityWithAccessionedSequence]

Species

Saccharomyces cerevisiae

Compartment

nucleoplasm

Synonyms

SUMO1-K-TOP2A, P06786

Locations in the PathwayBrowser

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Metabolism of proteins (Saccharomyces cerevisiae)

- Post-translational protein modification (Saccharomyces cerevisiae)
  - SUMOylation (Saccharomyces cerevisiae)
    - SUMO E3 ligases SUMOylate target proteins (Saccharomyces cerevisiae)
      - SUMOylation of DNA replication proteins (Saccharomyces cerevisiae)
        
        SUMOylation of TOP2A with SUMO1 (Saccharomyces cerevisiae)
        
        SUMO1:TOP2A [nucleoplasm] (Saccharomyces cerevisiae)
        
        TOP2 [nucleoplasm] (Saccharomyces cerevisiae)

External Reference Information

External Reference

UniProt:P06786

Gene Names

TOP2

Reference Genes

BioGPS Gene:855636 TOP2

ENSEMBL:YNL088W

KEGG Gene (Saccharomyces cerevisiae (strain YJM789)):YNL088W TOP2

Monarch:855636 TOP2

NCBI Gene:855636 TOP2

SGD:YNL088W

Reference Transcript

RefSeq:NM_001182926.3 TOP2

Other Identifiers

1779900_at

855636

8944_at

GO:0000019

GO:0000278

GO:0000712

GO:0000795

GO:0000819

GO:0003674

GO:0003677

GO:0003918

GO:0005524

GO:0005575

GO:0005634

GO:0005694

GO:0006260

GO:0006265

GO:0006271

GO:0006310

GO:0006325

GO:0006333

GO:0007059

GO:0007131

GO:0008150

GO:0016787

GO:0016853

GO:0016887

GO:0031055

GO:0042802

GO:0043167

GO:0044774

GO:0046872

GO:0048285

GO:0051052

GO:0051321

GO:0051726

GO:0097046

GO:0097047

Participant Of

hasComponent

SUMO1:TOP2A [nucleoplasm]

Other forms of this molecule

TOP2 [nucleoplasm]

Inferred From

SUMO1-K-TOP2A [nucleoplasm] (Homo sapiens)

Modified Residues

Name

UniProt:P06786 glycyl group sumoylated lysine

Modification

glycyl group

PsiMod Name

sumoylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.

Cross References

RefSeq

NP_014311.3

PRO

P06786

PDB

1BGW, 1BJT, 3L4J, 1QZR, 1PVG, 3L4K, 4GFH, 2RGR

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P06786	4	TOP2 [nucleoplasm] (R-SCE-4641359) TOP2 [nucleoplasm] (R-SCE-4641297) TOP2 [nucleoplasm] (R-SCE-4641367) TOP2 [nucleoplasm] (R-SCE-1362276)	0.825	5
UniProt:Q12159	2	YRA1 [cytosol] (R-SCE-158482) YRA1 [nucleoplasm] (R-SCE-156649)	0.564	6
UniProt:P10591	23	SSA1 [nucleoplasm] (R-SCE-5082380-2) SSA1 [cytosol] (R-SCE-264476-2) SSA1 [secretory granule lumen] (R-SCE-6801530-2) SSA1 [secretory granule lumen] (R-SCE-6801472-2) SSA1 [extracellular region] (R-SCE-6806500-2) SSA1 [extracellular region] (R-SCE-6805936-2) SSA1 [ficolin-1-rich granule lumen] (R-SCE-6801512-2) SSA1 [ficolin-1-rich granule lumen] (R-SCE-6801496-2) SSA1 [ficolin-1-rich granule lumen] (R-SCE-6801494-2) SSA1 [extracellular region] (R-SCE-6805872-2) SSA1 [nucleoplasm] (R-SCE-912480-2) SSA1 [nucleoplasm] (R-SCE-5082367-2) SSA1 [nucleoplasm] (R-SCE-6792605-2) SSA1 [nucleoplasm] (R-SCE-5252082-2) SSA1 [nucleoplasm] (R-SCE-5252088-2) SSA1 [nucleoplasm] (R-SCE-5252047-2) SSA1 [cytosol] (R-SCE-3371410-2) SSA1 [cytosol] (R-SCE-5251948-2) SSA1 [cytosol] (R-SCE-3371408-2) SSA1 [cytosol] (R-SCE-3371521-2) SSA1 [cytosol] (R-SCE-5251954-2) SSA1 [cytosol] (R-SCE-6792602-2) SSA1 [nucleoplasm] (R-SCE-8932217-2)	0.527	2
UniProt:P11484 SSB1			0.527	3
UniProt:P24583	37	PKC1 [nucleoplasm] (R-SCE-450530) PKC1 [nucleoplasm] (R-SCE-450606) PKC1 [cytosol] (R-SCE-58208) phospho-PKC1 [cytosol] (R-SCE-9632824) PKC1 [extracellular region] (R-SCE-6806199) PKC1 [extracellular region] (R-SCE-6806226) PKC1 [azurophil granule lumen] (R-SCE-6799219) PKC1 [azurophil granule lumen] (R-SCE-6799221) PKC1 [plasma membrane] (R-SCE-202346) phospho-PKC1 [plasma membrane] (R-SCE-202395) phospho-PKC1 [plasma membrane] (R-SCE-202152) PKC1 [cytosol] (R-SCE-212526) PKC1 [cytosol] (R-SCE-212514) PKC1 [cytosol] (R-SCE-58216) PKC1 [cytosol] (R-SCE-212551) PKC1 [cytosol] (R-SCE-212547) PKC1 [cytosol] (R-SCE-58202) PKC1 [plasma membrane] (R-SCE-156467) PKC1 [plasma membrane] (R-SCE-156469) PKC1 [cytosol] (R-SCE-58204) PKC1 [cytosol] (R-SCE-58196) phospho-PKC1 [nucleoplasm] (R-SCE-5223294) phospho-PKC1 [nucleoplasm] (R-SCE-5223292) phospho-PKC1 [cytosol] (R-SCE-5218731) phospho-PKC1 [cytosol] (R-SCE-5218746) phospho-PKC1 [cytosol] (R-SCE-5218728) phospho-PKC1 [cytosol] (R-SCE-437181) phospho-PKC1 [cytosol] (R-SCE-5218734) phospho-PKC1 [cytosol] (R-SCE-4332337) phospho-PKC1 [cytosol] (R-SCE-5218698) phospho-PKC1 [cytosol] (R-SCE-5218706) PKC1 [cytosol] (R-SCE-58198) PKC1 [cytosol] (R-SCE-58200) PKC1 [cytosol] (R-SCE-58218) phospho-PKC1 [plasma membrane] (R-SCE-2685606) phospho-PKC1 [plasma membrane] (R-SCE-198260) phospho-PKC1 [plasma membrane] (R-SCE-198294)	0.508	2

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