Reactome | HSP90AB1 [nucleoplasm]

HSP90AB1 [nucleoplasm]

Stable Identifier

R-SCE-5082399

Type

Protein [EntityWithAccessionedSequence]

Species

Saccharomyces cerevisiae

Compartment

nucleoplasm

Synonyms

P02829

Locations in the PathwayBrowser

Expand all

Signal Transduction (Saccharomyces cerevisiae)

- Signaling by Nuclear Receptors (Saccharomyces cerevisiae)
  - ESR-mediated signaling (Saccharomyces cerevisiae)
    - ESTG binds the ESR:chaperone complex (Saccharomyces cerevisiae)
      - ESRs:chaperone complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        HSP90 dimer:ATP [nucleoplasm] (Saccharomyces cerevisiae)
        
        HSP90:ATP [nucleoplasm] (Saccharomyces cerevisiae)
        
        HSP-90 [nucleoplasm] (Saccharomyces cerevisiae)
        
        HSP90AB1 [nucleoplasm] (Saccharomyces cerevisiae)
      - ESTG:ESRs:chaperone complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        ESRs:chaperone complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        HSP90 dimer:ATP [nucleoplasm] (Saccharomyces cerevisiae)
        
        HSP90:ATP [nucleoplasm] (Saccharomyces cerevisiae)
        
        HSP-90 [nucleoplasm] (Saccharomyces cerevisiae)
        
        HSP90AB1 [nucleoplasm] (Saccharomyces cerevisiae)

External Reference Information

External Reference

UniProt:P02829

Reference Genes

BioGPS Gene:855836

ENSEMBL:YPL240C

KEGG Gene (Saccharomyces cerevisiae (strain RM11-1a)):YPL240C

Monarch:855836

NCBI Gene:855836

SGD:YPL240C

Reference Transcript

RefSeq:NM_001184054.1

Other Identifiers

1A4H

1AH6

1AH8

1AM1

1AMW

1BGQ

1HK7

1US7

1USU

1USV

1ZW9

1ZWH

2AKP

2BRC

2BRE

2CG9

2CGE

2CGF

2FXS

2IWS

2IWU

2IWX

2LSV

2VW5

2VWC

2WEP

2WEQ

2WER

2XD6

2XX2

2XX4

2XX5

2YGA

2YGE

2YGF

3C0E

3C11

3FP2

4932.YPL240C

4AS9

4ASA

4ASB

4ASF

4ASG

4CE1

4CE2

4CE3

5MGX

CAA91604.1

CAA97961.1

DAA11197.1

EntrezGene:855836

EntrezGene:HSP82

GO:0000492

GO:0003674

GO:0005524

GO:0005575

GO:0005737

GO:0006457

GO:0006458

GO:0006605

GO:0006626

GO:0006970

GO:0007005

GO:0008150

GO:0015031

GO:0016787

GO:0016887

GO:0032200

GO:0032204

GO:0032212

GO:0033043

GO:0042026

GO:0042623

GO:0042802

GO:0043167

GO:0043248

GO:0051052

GO:0051082

GO:0051604

IPR001404

IPR003594

IPR019805

IPR020568

IPR020575

IPR036890

IPR037196

K01387

NM_001184054.1

NP_015084.1

PF00183

PF02518

PHI:463

PR00775

SM00387

UPI0000053297

YPL240C

YPL240C_mRNA

Participant Of

hasMember

hasComponent

HSP90-beta dimer [nucleoplasm]

Other forms of this molecule

HSP90AB1 [secretory granule lumen]

HSP90AA1 [secretory granule lumen]

HSP90AB1 [extracellular region]

HSP90AA1 [extracellular region]

HSP90AA1 [ficolin-1-rich granule lumen]

HSP90AB1 [ficolin-1-rich granule lumen]

HSP90AA1 [plasma membrane]

HSP90AB1 [cytosol]

HSP90AA1 [nucleoplasm]

HSP90AA1 [cytosol]

Inferred From

HSP90AB1 [nucleoplasm] (Homo sapiens)

Cross References

ZINC - Investigational

HSP82_YEAST

RefSeq

NP_015084.1

ZINC - Substances

HSP82_YEAST

ZINC target

P02829

PRO

P02829

ZINC - Predictions - Purchasable

HSP82_YEAST

PDB

3C0E, 4CE1, 4CE2, 2BRC, 1AM1, 2CGE, 2YGF, 4ASG, 1ZW9, 1BGQ, 4ASB, 2LSV, 2YGE, 2VWC, 4ASF, 2CG9, 1US7, 2AKP, 4ASA, 2XX5, 2YGA, 1A4H, 2XD6, 2FXS, 2XX4, 2IWU, 2WER, 1HK7, 1AH8, 2IWX, 4AS9, 2XX2, 2IWS, 2WEQ, 1AMW, 5MGX, 2VW5, 1USU, 2WEP, 3C11, 3FP2, 1ZWH, 1USV, 2CGF, 4CE3, 1AH6, 2BRE

Interactors (111)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P15705	1	STIP1 [cytosol] (R-SCE-443857)	0.971	43
UniProt:Q12449 AHA1			0.957	15
UniProt:P02829	11	HSP90AA1 [secretory granule lumen] (R-SCE-6801515) HSP90AB1 [secretory granule lumen] (R-SCE-6801477) HSP90AB1 [extracellular region] (R-SCE-6806463) HSP90AA1 [extracellular region] (R-SCE-3221946) HSP90AA1 [ficolin-1-rich granule lumen] (R-SCE-6801470) HSP90AB1 [ficolin-1-rich granule lumen] (R-SCE-6801491) HSP90AA1 [plasma membrane] (R-SCE-534996) HSP90AB1 [cytosol] (R-SCE-419617) HSP90AA1 [nucleoplasm] (R-SCE-5082401) HSP90AB1 [nucleoplasm] (R-SCE-5082399) HSP90AA1 [cytosol] (R-SCE-192864)	0.943	11
UniProt:P53691	1	PPID [nucleoplasm] (R-SCE-8939168)	0.935	27
UniProt:P25638 TAH1			0.922	11
UniProt:P53043	1	PPP5C [nucleoplasm] (R-SCE-5683410)	0.912	13
UniProt:P28707	2	PTGES3 [nucleoplasm] (R-SCE-5082403) PTGES3 [cytosol] (R-SCE-265269)	0.866	7
UniProt:P33313 CNS1			0.851	7
UniProt:P38768 PIH1			0.815	5
UniProt:P06101	3	CDC37L1 [platelet dense granule lumen] (R-SCE-8848903) CDC37L1 [extracellular region] (R-SCE-8848918) CDC37 [cytosol] (R-SCE-1221609)	0.791	6
UniProt:P47103 CYP7			0.771	6
UniProt:Q00772	4	MAPK3 [cytosol] (R-SCE-59284-4) MAPK3 [nucleoplasm] (R-SCE-73724-4) phospho-p-T202,Y204-MAPK3 [cytosol] (R-SCE-109842-4) phospho-p-T202,Y204-MAPK3 [nucleoplasm] (R-SCE-112359-4)	0.75	5
UniProt:P10591	23	HSPA8 [nucleoplasm] (R-SCE-5082380-2) HSPA8 [cytosol] (R-SCE-264476-2) HSPA6 [ficolin-1-rich granule lumen] (R-SCE-6801512-2) HSPA1A [ficolin-1-rich granule lumen] (R-SCE-6801496-2) HSPA8 [ficolin-1-rich granule lumen] (R-SCE-6801494-2) HSPA1A [extracellular region] (R-SCE-6805872-2) HSPA6 [extracellular region] (R-SCE-6806500-2) HSPA8 [extracellular region] (R-SCE-6805936-2) HSPA8 [secretory granule lumen] (R-SCE-6801530-2) HSPA6 [secretory granule lumen] (R-SCE-6801472-2) HSPA2 [nucleoplasm] (R-SCE-912480-2) HSPA1L [nucleoplasm] (R-SCE-5082367-2) HSPA1A [nucleoplasm] (R-SCE-6792605-2) HSPA6 [nucleoplasm] (R-SCE-5252088-2) HSPA13 [nucleoplasm] (R-SCE-5252009-2) HSPA7 [nucleoplasm] (R-SCE-5252047-2) HSPA1L [cytosol] (R-SCE-3371410-2) HSPA2 [cytosol] (R-SCE-3371408-2) HSPA13 [cytosol] (R-SCE-5251981-2) HSPA6 [cytosol] (R-SCE-3371521-2) HSPA7 [cytosol] (R-SCE-5251954-2) HSPA1A [cytosol] (R-SCE-6792602-2) Me3K561-HSPA8 [nucleoplasm] (R-SCE-8932217-2)	0.744	5
UniProt:P32589	5	HSPA4 [cytosol] (R-SCE-5251946) HSPH1 [cytosol] (R-SCE-3299412) HSPA4L [cytosol] (R-SCE-5251943) HSPA4 [nucleoplasm] (R-SCE-5251998) HSPA4L [nucleoplasm] (R-SCE-5252053)	0.721	5
UniProt:P0CS82 HAP1			0.721	4
UniProt:P38828 LSM12			0.688	3
UniProt:P33322	1	DKC1 [nucleoplasm] (R-SCE-163102)	0.688	4
UniProt:Q12407 YD199			0.678	3
UniProt:P15108	6	HSP90AA1 [extracellular region] (R-SCE-3221946-2) HSP90AA1 [secretory granule lumen] (R-SCE-6801515-2) HSP90AA1 [ficolin-1-rich granule lumen] (R-SCE-6801470-2) HSP90AA1 [plasma membrane] (R-SCE-534996-2) HSP90AA1 [nucleoplasm] (R-SCE-5082401-2) HSP90AA1 [cytosol] (R-SCE-192864-2)	0.678	46
UniProt:P04637 TP53	27	TP53 [cytosol] (R-HSA-8869337) Unfolded TP53 [cytosol] (R-HSA-6813797) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) SUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) Me2K-370,382-TP53 [nucleoplasm] (R-HSA-3222242) PolyUb,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6804446) p-T55-TP53 [nucleoplasm] (R-HSA-6805400) p-S15,S20,S392-TP53 [nucleoplasm] (R-HSA-6805053) p-S315-TP53 [nucleoplasm] (R-HSA-6805106) p-S15,S20,S269,T284-TP53 [nucleoplasm] (R-HSA-6805133) p-S15,S20,S46-TP53 [nucleoplasm] (R-HSA-6798369) p-S15,S33,S46-TP53 [nucleoplasm] (R-HSA-6805268) p-S37-TP53 [nucleoplasm] (R-HSA-3239022) p-S15,S392-TP53 [nucleoplasm] (R-HSA-3222015) Me1-K372,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805719) Me-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222124) MeK-370,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222226) p-S15,S20,Me-R333,Me2-R335,R337-TP53 [nucleoplasm] (R-HSA-6804378) Me2-K373-TP53 [nucleoplasm] (R-HSA-6805759) Ac-K120,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805656) Ac-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-5628868) Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805631) PolyUb-TP53 [nucleoplasm] (R-HSA-6793679) PolyUb-TP53 [cytosol] (R-HSA-6793681) p-S15,S20-TP53 [nucleoplasm] (R-HSA-69683) p-S15-TP53 [nucleoplasm] (R-HSA-69507) TP53 [nucleoplasm] (R-HSA-69488)	0.678	8
UniProt:P10592	23	HSPA8 [nucleoplasm] (R-SCE-5082380-3) HSPA8 [cytosol] (R-SCE-264476-3) HSPA6 [ficolin-1-rich granule lumen] (R-SCE-6801512-3) HSPA1A [ficolin-1-rich granule lumen] (R-SCE-6801496-3) HSPA8 [ficolin-1-rich granule lumen] (R-SCE-6801494-3) HSPA1A [extracellular region] (R-SCE-6805872-3) HSPA6 [extracellular region] (R-SCE-6806500-3) HSPA8 [extracellular region] (R-SCE-6805936-3) HSPA8 [secretory granule lumen] (R-SCE-6801530-3) HSPA6 [secretory granule lumen] (R-SCE-6801472-3) HSPA2 [nucleoplasm] (R-SCE-912480-3) HSPA1L [nucleoplasm] (R-SCE-5082367-3) HSPA1A [nucleoplasm] (R-SCE-6792605-3) HSPA6 [nucleoplasm] (R-SCE-5252088-3) HSPA13 [nucleoplasm] (R-SCE-5252009-3) HSPA7 [nucleoplasm] (R-SCE-5252047-3) HSPA1L [cytosol] (R-SCE-3371410-3) HSPA2 [cytosol] (R-SCE-3371408-3) HSPA13 [cytosol] (R-SCE-5251981-3) HSPA6 [cytosol] (R-SCE-3371521-3) HSPA7 [cytosol] (R-SCE-5251954-3) HSPA1A [cytosol] (R-SCE-6792602-3) Me3K561-HSPA8 [nucleoplasm] (R-SCE-8932217-3)	0.669	3
UniProt:P41808	4	MAPK3 [cytosol] (R-SCE-59284-3) MAPK3 [nucleoplasm] (R-SCE-73724-3) phospho-p-T202,Y204-MAPK3 [cytosol] (R-SCE-109842-3) phospho-p-T202,Y204-MAPK3 [nucleoplasm] (R-SCE-112359-3)	0.659	4
UniProt:Q08446	1	SUGT1 [cytosol] (R-SCE-874107)	0.623	2
UniProt:P15442 GCN2	2	p-T882,887-GCN2 [cytosol] (R-SCE-9633799) GCN2 [cytosol] (R-SCE-9633552)	0.621	3
UniProt:P25491	2	DNAJA4 [cytosol] (R-SCE-3371578) DNAJA2 [cytosol] (R-SCE-3371555)	0.621	3
UniProt:P60010 ACT			0.61	3
UniProt:P43581 HXT10			0.573	2
UniProt:Q08109 HRD1			0.564	3
UniProt:P25635 PWP2	2	PWP2 [nucleoplasm] (R-SCE-6790680) PWP2 [nucleoplasm] (R-SCE-6790632)	0.564	2
UniProt:P39534 MBB1			0.564	2
UniProt:Q07825	2	GPI-XPNPEP2 [plasma membrane] (R-SCE-8940794) cleaved GPI-XPNPEP2 [extracellular region] (R-SCE-8943379)	0.564	2
UniProt:P53834 HCH1			0.564	2
UniProt:P32832	2	SUZ12 [nucleoplasm] (R-SCE-212217) SUMO1-K75-SUZ12 [nucleoplasm] (R-SCE-4615932)	0.564	2
UniProt:P46672 ARC1			0.564	2
UniProt:P38264 PHO88			0.564	2
UniProt:P00359	2	GAPDHS [cytosol] (R-SCE-372873-2) GAPDH [cytosol] (R-SCE-70428)	0.564	2
UniProt:P38788	2	HSPA14 [nucleoplasm] (R-SCE-5252082) HSPA14 [cytosol] (R-SCE-5251948)	0.564	3
UniProt:P11484	23	HSPA8 [nucleoplasm] (R-SCE-5082380-4) HSPA8 [cytosol] (R-SCE-264476-4) HSPA6 [ficolin-1-rich granule lumen] (R-SCE-6801512-4) HSPA1A [ficolin-1-rich granule lumen] (R-SCE-6801496-4) HSPA8 [ficolin-1-rich granule lumen] (R-SCE-6801494-4) HSPA1A [extracellular region] (R-SCE-6805872-4) HSPA6 [extracellular region] (R-SCE-6806500-4) HSPA8 [extracellular region] (R-SCE-6805936-4) HSPA8 [secretory granule lumen] (R-SCE-6801530-4) HSPA6 [secretory granule lumen] (R-SCE-6801472-4) HSPA2 [nucleoplasm] (R-SCE-912480-4) HSPA1L [nucleoplasm] (R-SCE-5082367-4) HSPA1A [nucleoplasm] (R-SCE-6792605-4) HSPA6 [nucleoplasm] (R-SCE-5252088-4) HSPA13 [nucleoplasm] (R-SCE-5252009-4) HSPA7 [nucleoplasm] (R-SCE-5252047-4) HSPA1L [cytosol] (R-SCE-3371410-4) HSPA2 [cytosol] (R-SCE-3371408-4) HSPA13 [cytosol] (R-SCE-5251981-4) HSPA6 [cytosol] (R-SCE-3371521-4) HSPA7 [cytosol] (R-SCE-5251954-4) HSPA1A [cytosol] (R-SCE-6792602-4) Me3K561-HSPA8 [nucleoplasm] (R-SCE-8932217-4)	0.564	3
UniProt:Q12276 HER1			0.564	2
UniProt:P53743 ESF2			0.564	2
UniProt:P38241 SLT11			0.564	4
UniProt:P41811	3	COPB2 [cytosol] (R-SCE-199972) COPB2 [endoplasmic reticulum membrane] (R-SCE-6810957) COPB2 [transport vesicle] (R-SCE-6808741)	0.564	2
UniProt:P38887 YH02			0.564	2
UniProt:P38764	4	PSMD2 [extracellular region] (R-SCE-6806479) PSMD2 [secretory granule lumen] (R-SCE-6800919) PSMD2 [ficolin-1-rich granule lumen] (R-SCE-6800435) PSMD2 [cytosol] (R-SCE-68796)	0.564	2
UniProt:P17883 SKI3	1	TTC37 [cytosol] (R-SCE-8931541)	0.564	2
UniProt:P33759 RT05			0.564	12
UniProt:P53874 UBP10			0.564	2
UniProt:P53599	7	K48polyUb-NIK [cytosol] (R-SCE-5668525) phospho-p-T559-MAP3K14 [cytosol] (R-SCE-5668531) phospho-p-MAP3K14 [cytosol] (R-SCE-168187) phospho-p-S400-MAP3K8 [cytosol] (R-SCE-389738-2) MAP3K14 [cytosol] (R-SCE-168189) MAP3K8 [cytosol] (R-SCE-389388-2) phospho-p-S400,T290-MAP3K8 [cytosol] (R-SCE-5684259-2)	0.564	2
UniProt:Q06224	1	CPSF3 [nucleoplasm] (R-SCE-71993)	0.564	2
UniProt:Q01454 CTF4			0.564	2
UniProt:Q12102	1	CPSF2 [nucleoplasm] (R-SCE-71991)	0.564	2
UniProt:P00830 ATP2	4	ATP2 precursor [mitochondrial inner membrane] (R-SCE-1252057) ATP2 [mitochondrial inner membrane] (R-SCE-1267966) ATP2 precursor [mitochondrial intermembrane space] (R-SCE-1252202) ATP2 precursor [cytosol] (R-SCE-1252203)	0.564	2
UniProt:P38746 YLF2			0.564	2
UniProt:Q07786	1	SORD [cytosol] (R-SCE-5652193-2)	0.553	2
UniProt:P38272 SHE3			0.553	2
UniProt:P38356 BSD2			0.553	2
UniProt:Q06598 ARR3			0.553	2
UniProt:Q12051	1	GGPS1 [cytosol] (R-SCE-191415)	0.547	2
UniProt:P38555	2	RAB25 [cytosol] (R-SCE-8873683) GGC-RAB25 [cytosol] (R-SCE-8873780)	0.547	2
UniProt:Q06604 BSP1			0.547	2
UniProt:Q08227	8	OCRL [cytoplasmic vesicle membrane] (R-SCE-434214) OCRL [Golgi membrane] (R-SCE-434339) INPP5B(321-993) [cytosol] (R-SCE-200626) INPP5B(321-993) [plasma membrane] (R-SCE-2023845) OCRL [plasma membrane] (R-SCE-3769049) OCRL [cytosol] (R-SCE-1806196) INPP5J [cytosol] (R-SCE-1604590) INPP5K [cytosol] (R-SCE-1806175)	0.547	2
UniProt:Q06696	1	VPS36 [cytosol] (R-SCE-917709)	0.547	2
UniProt:Q12329 HSP42			0.547	2
UniProt:P19882 HSP60	6	HSPD1(1-26) [mitochondrial matrix] (R-SCE-8986171) HSP60 precursor [mitochondrial inner membrane] (R-SCE-1267967) HSP60 precursor [mitochondrial intermembrane space] (R-SCE-1252158) HSP60 [cytosol] (R-SCE-1252153) HSP60 [mitochondrial matrix] (R-SCE-1252181) HSP60 [mitochondrial inner membrane] (R-SCE-1267982)	0.547	2
UniProt:P07248	1	MECOM [nucleoplasm] (R-SCE-8943897)	0.547	2
UniProt:P38720	1	PGD [cytosol] (R-SCE-71297)	0.547	2
UniProt:P32468	1	SEPT7 [cytosol] (R-SCE-5692671-2)	0.547	2
UniProt:P22516 CHL1			0.547	2
UniProt:P46956 PHO86			0.547	2
UniProt:P38429 SAP30			0.547	2
UniProt:P25644	1	PATL1 [cytosol] (R-SCE-2028617)	0.547	2
UniProt:Q07732 ADY3			0.547	2
UniProt:Q06523 YP148			0.547	2
UniProt:Q08278 MED7			0.547	2
UniProt:Q06892 POS5			0.547	2
UniProt:P22203	2	ATP6V1E1 [cytosol] (R-SCE-912606) ATP6V1E2 [cytosol] (R-SCE-912579)	0.547	2
UniProt:P04076	1	ASL [cytosol] (R-SCE-70570)	0.547	2
UniProt:P02293	15	HIST1H2BA [nucleoplasm] (R-SCE-181916) HIST1H2BK [nucleoplasm] (R-SCE-181898) AcK6-HIST1H2BB [nucleoplasm] (R-SCE-4568637) AcK16-HIST1H2BB [nucleoplasm] (R-SCE-4568639) AcK13-HIST1H2BB [nucleoplasm] (R-SCE-4568629) AcK21-HIST1H2BB [nucleoplasm] (R-SCE-4568632) AcK16-HIST2H2BE [nucleoplasm] (R-SCE-4568660) AcK22-HIST1H2BA [nucleoplasm] (R-SCE-4568647) AcK17-HIST1H2BA [nucleoplasm] (R-SCE-4568631) AcK14-HIST1H2BA [nucleoplasm] (R-SCE-4568615) AcK7-HIST1H2BA [nucleoplasm] (R-SCE-4568624) AcK-HIST1H2BB [nucleoplasm] (R-SCE-4549272) AcK-HIST1H2BA [nucleoplasm] (R-SCE-4549263) Ub-HIST1H2BB [nucleoplasm] (R-SCE-6782554) Ub-HIST1H2BA [nucleoplasm] (R-SCE-6782561)	0.547	2
UniProt:P33200 PDR3			0.547	2
UniProt:Q06106	1	HNRNPM [nucleoplasm] (R-SCE-71949-4)	0.547	2
UniProt:P27636 CDC15			0.547	2
UniProt:P20967	1	OGDH [mitochondrial matrix] (R-SCE-69981)	0.547	2
UniProt:P38866 FMO1			0.547	3
UniProt:P32485	16	MAPK14 [secretory granule lumen] (R-SCE-6803300) MAPK12 [nucleoplasm] (R-SCE-448833) MAPK14 [extracellular region] (R-SCE-6806453) MAPK14 [ficolin-1-rich granule lumen] (R-SCE-6803280) phospho-p-T183,Y185-MAPK12 [cytosol] (R-SCE-171021) phospho-p-T180,Y182-MAPK13 [cytosol] (R-SCE-171022) MAPK11 [cytosol] (R-SCE-170989) MAPK13 [cytosol] (R-SCE-171012) MAPK12 [cytosol] (R-SCE-171025) phospho-p-T180,Y182-MAPK11 [cytosol] (R-SCE-171009) MAPK11 [nucleoplasm] (R-SCE-203790) MAPK14 [nucleoplasm] (R-SCE-446223) phospho-p-T180,Y182-MAPK11 [nucleoplasm] (R-SCE-198741) phospho-p-T180,Y182-MAPK14 [nucleoplasm] (R-SCE-446227) MAPK14 [cytosol] (R-SCE-428933) phospho-p-T180,Y182-MAPK14 [cytosol] (R-SCE-428935)	0.547	2
UniProt:P04802 SYDC			0.547	2
UniProt:Q99190	2	TECRL [endoplasmic reticulum membrane] (R-SCE-4127427) TECR [endoplasmic reticulum membrane] (R-SCE-548663)	0.547	2
UniProt:Q08144	2	STX17 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-SCE-6807769) STX16 [trans-Golgi network membrane] (R-SCE-6811002)	0.547	2
UniProt:P14681	4	MAPK3 [cytosol] (R-SCE-59284) MAPK3 [nucleoplasm] (R-SCE-73724) phospho-p-T202,Y204-MAPK3 [cytosol] (R-SCE-109842) phospho-p-T202,Y204-MAPK3 [nucleoplasm] (R-SCE-112359)	0.547	2
UniProt:Q12511 PDP1			0.547	2
UniProt:P06700	1	SIRT1 [nucleoplasm] (R-SCE-427531)	0.547	2
UniProt:P40359	1	GINS2 [nucleoplasm] (R-SCE-176975)	0.527	2
UniProt:P04385 GAL1			0.527	2
UniProt:P39011 BEM4			0.527	2
UniProt:P38688	1	SRP72 [cytosol] (R-SCE-265069)	0.527	2
UniProt:P27801 PEP3			0.527	2
UniProt:Q03330	2	KAT2A [nucleoplasm] (R-SCE-3006516) KAT2B [nucleoplasm] (R-SCE-352430)	0.527	2
UniProt:P54860	1	UBE4A [cytosol] (R-SCE-976022)	0.527	2
UniProt:P32259 MED16			0.527	2
UniProt:P38129	1	TAF5 [nucleoplasm] (R-SCE-65543)	0.527	3
UniProt:P12753 RAD50	1	DNA repair protein RAD50 [nucleoplasm] (R-SCE-981774)	0.527	2
UniProt:P17157 PHO85			0.527	2
UniProt:P52918	2	XPO5 [nucleoplasm] (R-SCE-847721) XPO5 [cytosol] (R-SCE-847719)	0.527	2
UniProt:Q12347	1	FBXO9 [cytosol] (R-SCE-8862608)	0.527	2
UniProt:P38629	1	RFC5 [nucleoplasm] (R-SCE-68427)	0.527	2
UniProt:Q06640 YD306			0.527	2
UniProt:Q08387 DNLI4			0.527	2
UniProt:P22336	1	RPA1 [nucleoplasm] (R-SCE-68461)	0.527	2
UniProt:P27616 PUR7			0.508	2
UniProt:P37898	5	ERAP1 [endoplasmic reticulum lumen] (R-SCE-947609-2) LNPEP [cytosol] (R-SCE-983098-2) ERAP2 [endoplasmic reticulum lumen] (R-SCE-983097-2) ANPEP [plasma membrane] (R-SCE-2022340-2) ANPEP [secretory granule membrane] (R-SCE-6806152-2)	0.508	4
UniProt:P53858	2	PHACTR2 [platelet alpha granule membrane] (R-SCE-8848893) PHACTR2 [plasma membrane] (R-SCE-8848883)	0.508	2
UniProt:P23561 STE11			0.488	2