Reactome | HSP82 [nucleoplasm]

HSP82 [nucleoplasm]

Stable Identifier

R-SCE-5082399

Type

Protein [EntityWithAccessionedSequence]

Species

Saccharomyces cerevisiae

Compartment

nucleoplasm

Synonyms

HSP90AB1, P02829

Locations in the PathwayBrowser

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Cellular responses to external stimuli (Saccharomyces cerevisiae)

- Cellular responses to stress (Saccharomyces cerevisiae)
  - Cellular response to heat stress (Saccharomyces cerevisiae)
    - HSF1 activation (Saccharomyces cerevisiae)
      - Dissociation of HSF1:HSP90 complex in the nucleus (Saccharomyces cerevisiae)
        
        HSF1:HSP90:PTGES3 [nucleoplasm] (Saccharomyces cerevisiae)
        
        HSP90:HSP90 [nucleoplasm] (Saccharomyces cerevisiae)
        
        HSP90-beta dimer [nucleoplasm] (Saccharomyces cerevisiae)
        
        Homologues of HSP90AB1 [nucleoplasm] (Saccharomyces cerevisiae)
        
        HSP82 [nucleoplasm] (Saccharomyces cerevisiae)
        
        HSP90:HSP90 [nucleoplasm] (Saccharomyces cerevisiae)
        
        HSP90-beta dimer [nucleoplasm] (Saccharomyces cerevisiae)
        
        Homologues of HSP90AB1 [nucleoplasm] (Saccharomyces cerevisiae)
        
        HSP82 [nucleoplasm] (Saccharomyces cerevisiae)
    - HSF1-dependent transactivation (Saccharomyces cerevisiae)
      - HSF1-mediated gene expression (Saccharomyces cerevisiae)
        
        Heat shock inducible proteins [nucleoplasm] (Saccharomyces cerevisiae)
        
        Homologues of HSP90AB1 [nucleoplasm] (Saccharomyces cerevisiae)
        
        HSP82 [nucleoplasm] (Saccharomyces cerevisiae)

Signal Transduction (Saccharomyces cerevisiae)

- Signaling by Nuclear Receptors (Saccharomyces cerevisiae)
  - ESR-mediated signaling (Saccharomyces cerevisiae)
    - ESTG binds the ESR:chaperone complex (Saccharomyces cerevisiae)
      - ESRs:chaperone complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        HSP90 dimer:ATP [nucleoplasm] (Saccharomyces cerevisiae)
        
        HSP90:ATP [nucleoplasm] (Saccharomyces cerevisiae)
        
        HSP-90 [nucleoplasm] (Saccharomyces cerevisiae)
        
        Homologues of HSP90AB1 [nucleoplasm] (Saccharomyces cerevisiae)
        
        HSP82 [nucleoplasm] (Saccharomyces cerevisiae)
      - ESTG:ESRs:chaperone complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        ESRs:chaperone complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        HSP90 dimer:ATP [nucleoplasm] (Saccharomyces cerevisiae)
        
        HSP90:ATP [nucleoplasm] (Saccharomyces cerevisiae)
        
        HSP-90 [nucleoplasm] (Saccharomyces cerevisiae)
        
        Homologues of HSP90AB1 [nucleoplasm] (Saccharomyces cerevisiae)
        
        HSP82 [nucleoplasm] (Saccharomyces cerevisiae)

External Reference Information

External Reference

UniProt:P02829

Gene Names

HSP82

Reference Genes

BioGPS Gene:855836 HSP82

ENSEMBL:YPL240C

KEGG Gene (Saccharomyces cerevisiae (strain RM11-1a)):YPL240C HSP82

Monarch:855836 HSP82

NCBI Gene:855836 HSP82

SGD:YPL240C

Reference Transcript

RefSeq:NM_001184054.1 HSP82

Other Identifiers

1773612_at

8010_i_at

855836

9457_g_at

GO:0000492

GO:0003674

GO:0005524

GO:0005575

GO:0005737

GO:0006457

GO:0006458

GO:0006605

GO:0006626

GO:0006970

GO:0007005

GO:0008150

GO:0015031

GO:0016787

GO:0016887

GO:0032200

GO:0032204

GO:0032212

GO:0033043

GO:0042026

GO:0042623

GO:0042802

GO:0043167

GO:0043248

GO:0051052

GO:0051082

GO:0051604

Participant Of

hasMember

Homologues of HSP90AB1 [nucleoplasm]

Other forms of this molecule

HSP82 [ficolin-1-rich granule lumen]

HSP82 [extracellular region]

HSP82 [secretory granule lumen]

HSP82 [plasma membrane]

HSP82 [cytosol]

HSP82 [nucleoplasm]

HSP82 [cytosol]

Inferred From

HSP90AB1 [nucleoplasm] (Homo sapiens)

Cross References

ZINC - Investigational

HSP82_YEAST

RefSeq

NP_015084.1

ZINC - Substances

HSP82_YEAST

ZINC target

P02829

PRO

P02829

ZINC - Predictions - Purchasable

HSP82_YEAST

PDB

5MGX, 4CE1, 1AM1, 2XX5, 1BGQ, 2BRC, 1US7, 4ASG, 1USV, 1AH6, 3C0E, 2CG9, 2WEP, 2LSV, 2CGF, 2YGF, 2XD6, 2IWX, 4AS9, 1AMW, 2XX4, 3FP2, 4CE3, 2AKP, 2VW5, 4ASF, 1USU, 1HK7, 1ZW9, 2YGE, 2IWU, 2CGE, 1A4H, 2FXS, 2XX2, 4ASB, 3C11, 4CE2, 2WER, 2VWC, 2YGA, 1ZWH, 2IWS, 2BRE, 1AH8, 4ASA, 2WEQ

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P15705	1	STI1 [cytosol] (R-SCE-443857)	0.971	43
UniProt:P28707	2	SBA1 [nucleoplasm] (R-SCE-5082403) SBA1 [cytosol] (R-SCE-265269)	0.866	7
UniProt:Q00772	39	SLT2 [nucleoplasm] (R-SCE-5686975-3) SLT2 [cytosol] (R-SCE-5687000-3) SLT2 [cytosol] (R-SCE-5686973-3) SLT2 [cytosol] (R-SCE-5686979-3) phospho-SLT2 [cytosol] (R-SCE-5687019-3) phospho-SLT2 [cytosol] (R-SCE-5687023-3) phospho-SLT2 [nucleoplasm] (R-SCE-5687022-3) phospho-SLT2 [nucleoplasm] (R-SCE-5687015-3) SLT2 [nucleoplasm] (R-SCE-5692686-3) phospho-SLT2 [nucleoplasm] (R-SCE-5692665-3) SLT2 [nucleoplasm] (R-SCE-448833-3) SLT2 [ficolin-1-rich granule lumen] (R-SCE-6803280-3) SLT2 [extracellular region] (R-SCE-6806453-3) phospho-SLT2 [nucleoplasm] (R-SCE-450311-3) phospho-SLT2 [nucleoplasm] (R-SCE-450319-3) phospho-SLT2 [nucleoplasm] (R-SCE-216349-3) phospho-SLT2 [nucleoplasm] (R-SCE-446227-3) phospho-SLT2 [nucleoplasm] (R-SCE-198741-3) phospho-SLT2 [cytosol] (R-SCE-428935-3) SLT2 [cytosol] (R-SCE-428933-3) phospho-SLT2 [cytosol] (R-SCE-450214-3) phospho-SLT2 [cytosol] (R-SCE-194371-3) phospho-SLT2 [cytosol] (R-SCE-450293-3) SLT2 [cytosol] (R-SCE-450355-3) SLT2 [cytosol] (R-SCE-450352-3) SLT2 [cytosol] (R-SCE-168141-3) phospho-SLT2 [nucleoplasm] (R-SCE-198738) phospho-SLT2 [cytosol] (R-SCE-198721) SLT2 [cytosol] (R-SCE-4411330-3) phospho-SLT2 [cytosol] (R-SCE-4411398-3) phospho-SLT2 [nucleoplasm] (R-SCE-4411376-3) phospho-SLT2 [cytosol] (R-SCE-171021-3) SLT2 [cytosol] (R-SCE-171025-3) phospho-SLT2 [cytosol] (R-SCE-171009-3) SLT2 [nucleoplasm] (R-SCE-199961) SLT2 [cytosol] (R-SCE-171012-3) SLT2 [cytosol] (R-SCE-170989-3) phospho-SLT2 [cytosol] (R-SCE-171022-3) SLT2 [secretory granule lumen] (R-SCE-6803300-3)	0.75	5
UniProt:P33322	1	CBF5 [nucleoplasm] (R-SCE-163102)	0.688	4
UniProt:P04637 TP53	27	TP53 [cytosol] (R-HSA-8869337) Unfolded TP53 [cytosol] (R-HSA-6813797) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) SUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) Me2K-370,382-TP53 [nucleoplasm] (R-HSA-3222242) p-S15,S33,S46-TP53 [nucleoplasm] (R-HSA-6805268) p-S15,S392-TP53 [nucleoplasm] (R-HSA-3222015) p-T55-TP53 [nucleoplasm] (R-HSA-6805400) p-S15,S20,S392-TP53 [nucleoplasm] (R-HSA-6805053) p-S15,S20,S269,T284-TP53 [nucleoplasm] (R-HSA-6805133) p-S315-TP53 [nucleoplasm] (R-HSA-6805106) Ac-K120,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805656) Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805631) Ac-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-5628868) Me2-K373-TP53 [nucleoplasm] (R-HSA-6805759) MeK-370,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222226) p-S15,S20,Me-R333,Me2-R335,R337-TP53 [nucleoplasm] (R-HSA-6804378) Me-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222124) Me1-K372,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805719) p-S15,S20,S46-TP53 [nucleoplasm] (R-HSA-6798369) p-S37-TP53 [nucleoplasm] (R-HSA-3239022) PolyUb,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6804446) PolyUb-TP53 [nucleoplasm] (R-HSA-6793679) PolyUb-TP53 [cytosol] (R-HSA-6793681) p-S15,S20-TP53 [nucleoplasm] (R-HSA-69683) p-S15-TP53 [nucleoplasm] (R-HSA-69507) TP53 [nucleoplasm] (R-HSA-69488)	0.678	8
UniProt:Q08446	1	SGT1 [cytosol] (R-SCE-874107)	0.623	2
UniProt:P15442 GCN2	3	GCN2 [endoplasmic reticulum membrane] (R-SCE-381046) GCN2 [cytosol] (R-SCE-9633552) p-T882,887-GCN2 [cytosol] (R-SCE-9633799)	0.621	3
UniProt:Q08227	2	INP54 [cytosol] (R-SCE-1806175) INP54 [cytosol] (R-SCE-1604590)	0.547	2
UniProt:Q08144	1	TLG2 [trans-Golgi network membrane] (R-SCE-6811002)	0.547	2
UniProt:Q99190	2	TSC13 [endoplasmic reticulum membrane] (R-SCE-4127427) TSC13 [endoplasmic reticulum membrane] (R-SCE-548663)	0.547	2
UniProt:P12753 RAD50	1	DNA repair protein RAD50 [nucleoplasm] (R-SCE-981774)	0.527	2
UniProt:P40359	1	PSF2 [nucleoplasm] (R-SCE-176975)	0.527	2
UniProt:P23561	1	STE11 [cytosol] (R-SCE-167709)	0.488	2

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