Reactome | CBC2 [nucleoplasm]

CBC2 [nucleoplasm]

Stable Identifier

R-SCE-51463

Type

Protein [EntityWithAccessionedSequence]

Species

Saccharomyces cerevisiae

Compartment

nucleoplasm

Synonyms

NCBP2, Q08920

Locations in the PathwayBrowser

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Gene expression (Transcription) (Saccharomyces cerevisiae)

- RNA Polymerase II Transcription (Saccharomyces cerevisiae)
  - RNA Polymerase II Pre-transcription Events (Saccharomyces cerevisiae)
    - Abortive termination of early transcription elongation by DSIF:NELF (Saccharomyces cerevisiae)
      - DSIF:NELF:early elongation complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        RNA Pol II (hypophosphorylated) complex bound to DSIF protein [nucleoplasm] (Saccharomyces cerevisiae)
        
        RNA Pol II (hypophosphorylated):capped pre-mRNA complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Saccharomyces cerevisiae)
        
        CBC2 [nucleoplasm] (Saccharomyces cerevisiae)
  - RNA Polymerase II Transcription Elongation (Saccharomyces cerevisiae)
    - Formation of the Early Elongation Complex (Saccharomyces cerevisiae)
      - DSIF complex binds to RNA Pol II (hypophosphorylated) (Saccharomyces cerevisiae)
        
        RNA Pol II (hypophosphorylated) complex bound to DSIF protein [nucleoplasm] (Saccharomyces cerevisiae)
        
        RNA Pol II (hypophosphorylated):capped pre-mRNA complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Saccharomyces cerevisiae)
        
        CBC2 [nucleoplasm] (Saccharomyces cerevisiae)
        
        RNA Pol II (hypophosphorylated):capped pre-mRNA complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Saccharomyces cerevisiae)
        
        CBC2 [nucleoplasm] (Saccharomyces cerevisiae)
      - Hypophosphorylation of RNA Pol II CTD by FCP1P protein (Saccharomyces cerevisiae)
        
        RNA Pol II (hypophosphorylated):capped pre-mRNA complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Saccharomyces cerevisiae)
        
        CBC2 [nucleoplasm] (Saccharomyces cerevisiae)
        
        capped pre-mRNA:CBC:RNA Pol II (phosphorylated) complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Saccharomyces cerevisiae)
        
        CBC2 [nucleoplasm] (Saccharomyces cerevisiae)

External Reference Information

External Reference

UniProt:Q08920

Gene Names

CBC2

Reference Genes

BioGPS Gene:855925 CBC2

ENSEMBL:YPL178W

KEGG Gene (Saccharomyces cerevisiae (strain RM11-1a)):YPL178W CBC2

Monarch:855925 CBC2

NCBI Gene:855925 CBC2

SGD:YPL178W

Reference Transcript

RefSeq:NM_001183992.1 CBC2

Other Identifiers

1770708_at

7937_at

855925

GO:0000184

GO:0000243

GO:0000339

GO:0000398

GO:0003674

GO:0003676

GO:0003723

GO:0005575

GO:0005634

GO:0005737

GO:0005846

GO:0006397

GO:0006401

GO:0008150

GO:0008380

GO:0015931

GO:0045292

GO:0048471

GO:0051028

Participant Of

hasComponent

input

Formation of cap binding complex (CBC)

Other forms of this molecule

CBC2 [cytosol]

Inferred From

NCBP2 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_015147.1

PRO

Q08920

PDB

6N7P

Interactors (17)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P34160	2	STO1 [nucleoplasm] (R-SCE-51469) STO1 [cytosol] (R-SCE-162459)	0.818	25
UniProt:Q02821	2	SRP1 [cytosol] (R-SCE-205976) SRP1 [cytosol] (R-SCE-180612)	0.771	11
UniProt:Q06142	4	KAP95 [extracellular region] (R-SCE-6806306) KAP95 [ficolin-1-rich granule lumen] (R-SCE-6800978) KAP95 [specific granule lumen] (R-SCE-6799646) KAP95 [cytosol] (R-SCE-180733)	0.669	6
UniProt:P53617 NRD1			0.643	3
UniProt:Q03735 NAB6			0.527	2
UniProt:P10591	23	SSA1 [nucleoplasm] (R-SCE-5082380-2) SSA1 [cytosol] (R-SCE-264476-2) SSA1 [secretory granule lumen] (R-SCE-6801530-2) SSA1 [secretory granule lumen] (R-SCE-6801472-2) SSA1 [extracellular region] (R-SCE-6806500-2) SSA1 [extracellular region] (R-SCE-6805936-2) SSA1 [ficolin-1-rich granule lumen] (R-SCE-6801512-2) SSA1 [ficolin-1-rich granule lumen] (R-SCE-6801496-2) SSA1 [ficolin-1-rich granule lumen] (R-SCE-6801494-2) SSA1 [extracellular region] (R-SCE-6805872-2) SSA1 [nucleoplasm] (R-SCE-6792605-2) SSA1 [nucleoplasm] (R-SCE-912480-2) SSA1 [nucleoplasm] (R-SCE-5082367-2) SSA1 [nucleoplasm] (R-SCE-5252082-2) SSA1 [nucleoplasm] (R-SCE-5252088-2) SSA1 [nucleoplasm] (R-SCE-5252047-2) SSA1 [cytosol] (R-SCE-3371410-2) SSA1 [cytosol] (R-SCE-5251948-2) SSA1 [cytosol] (R-SCE-3371408-2) SSA1 [cytosol] (R-SCE-3371521-2) SSA1 [cytosol] (R-SCE-5251954-2) SSA1 [cytosol] (R-SCE-6792602-2) SSA1 [nucleoplasm] (R-SCE-8932217-2)	0.527	2
UniProt:Q07508 LUC7			0.527	2
UniProt:Q00539 NAM8			0.527	3
UniProt:P11484 SSB1			0.527	2
UniProt:Q06217	1	SMD2 [cytosol] (R-SCE-191810)	0.527	2
UniProt:Q01560 NOP3			0.527	2
UniProt:Q03782 SNU56			0.527	2
UniProt:P39936	2	TIF4632 [cytosol] (R-SCE-72584-2) phospho-TIF4632 [cytosol] (R-SCE-165762-2)	0.527	2
UniProt:P53207 SNU71			0.527	3
UniProt:Q04693 RSE1			0.527	2
UniProt:Q00916 RU17			0.527	2
UniProt:P38996	2	NAB3 [nucleoplasm] (R-SCE-71933) NAB3 [nucleoplasm] (R-SCE-4570543)	0.527	3