Reactome | diphthine EFT1 [cytosol]

diphthine EFT1 [cytosol]

Stable Identifier

R-SCE-5367015

Type

Protein [EntityWithAccessionedSequence]

Species

Saccharomyces cerevisiae

Compartment

cytosol

Synonyms

diphthine Elongation factor 2

Literature References

PubMed ID	Title	Journal	Year
24739148	Dph7 catalyzes a previously unknown demethylation step in diphthamide biosynthesis Lin, Z, Su, X, Chen, W, Ci, B, Zhang, S, Lin, H	J. Am. Chem. Soc.	2014

External Reference Information

External Reference

UniProt:P32324 EFT1

Gene Names

EFT1, YOR133W, O3317, YOR3317W, EFT2, YDR385W

Chain

chain:1-842

Reference Genes

BioGPS Gene:851993 EFT1

BioGPS Gene:854301 EFT1

KEGG Gene (Saccharomyces cerevisiae (strain RM11-1a)):YDR385W EFT1

KEGG Gene (Saccharomyces cerevisiae (strain RM11-1a)):YOR133W EFT1

Monarch:851993 EFT1

Monarch:854301 EFT1

NCBI Gene:851993 EFT1

NCBI Gene:854301 EFT1

Reference Transcript

Other Identifiers

1777413_s_at

8425_s_at

851993

854301

GO:0003674

GO:0003723

GO:0003746

GO:0003924

GO:0005525

GO:0005575

GO:0005737

GO:0005829

GO:0006414

GO:0006417

GO:0008135

GO:0008150

GO:0016787

GO:0019843

GO:0043167

GO:0045901

GO:1990145

Participant Of

output

Diphthamide biosynthesis protein 7 hydrolyzes a methyl group on Me-diphthine elongation factor 2

Other forms of this molecule

EFT2 [cytosol]

Me-diphthine EFT1 [cytosol]

EFT2 [cytosol]

EFT2 [secretory granule lumen]

EFT2 [extracellular region]

EFT2 [ficolin-1-rich granule lumen]

EFT2 [cytosol]

Modified Residues

Name

modified L-histidine residue (diphthine residue) at 699

Coordinate

699

Modification

diphthine residue

PsiMod Name

modified L-histidine residue

PsiMod Definition

A protein modification that modifies an L-histidine residue.

Cross References

RefSeq

NP_014776.1, NP_010673.1

PRO

P32324

PDB

1ZM3, 1ZM2, 4V4B, 3DNY, 5JUS, 1N0U, 6GQV, 1N0V, 1ZM4, 5JUT, 3B8H, 3B78, 1ZM9, 2ZIT, 5JUU, 1U2R, 6GQ1, 2E1R, 2NPF, 3B82, 2P8W, 2P8X, 5JUP, 6GQB, 5JUO, 2P8Y, 2P8Z

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P48362 HGH1			0.715	7
UniProt:P40487	1	DPH1 [cytosol] (R-SCE-5358384)	0.611	23
UniProt:P32469	1	DPH5 [cytosol] (R-SCE-5358485)	0.595	3
UniProt:P32461	1	DPH2 [cytosol] (R-SCE-5358368)	0.573	25
UniProt:P32324 EFT1	11	diphthine EFT1 [cytosol] (R-SCE-5367015) EFT2 [cytosol] (R-SCE-8932237) Me-diphthine EFT1 [cytosol] (R-SCE-5367013) EFT2 [cytosol] (R-SCE-156901) EFT2 [cytosol] (R-SCE-5358501) EFT2 [cytosol] (R-SCE-5358472) EFT2 [secretory granule lumen] (R-SCE-6801504) EFT2 [extracellular region] (R-SCE-6806499) EFT2 [ficolin-1-rich granule lumen] (R-SCE-6801513) EFT2 [cytosol] (R-SCE-5358478) EFT2 [cytosol] (R-SCE-5367025)	0.573	58
UniProt:Q02821	2	SRP1 [cytosol] (R-SCE-205976) SRP1 [cytosol] (R-SCE-180612)	0.564	2
UniProt:P40150 SSB2			0.564	2
UniProt:P41940 MPG1			0.547	2
UniProt:P42842 EMW1			0.547	3
UniProt:P10591	23	SSA1 [nucleoplasm] (R-SCE-5082380-2) SSA1 [cytosol] (R-SCE-264476-2) SSA1 [secretory granule lumen] (R-SCE-6801530-2) SSA1 [secretory granule lumen] (R-SCE-6801472-2) SSA1 [extracellular region] (R-SCE-6806500-2) SSA1 [extracellular region] (R-SCE-6805936-2) SSA1 [ficolin-1-rich granule lumen] (R-SCE-6801512-2) SSA1 [ficolin-1-rich granule lumen] (R-SCE-6801496-2) SSA1 [ficolin-1-rich granule lumen] (R-SCE-6801494-2) SSA1 [extracellular region] (R-SCE-6805872-2) SSA1 [nucleoplasm] (R-SCE-6792605-2) SSA1 [nucleoplasm] (R-SCE-912480-2) SSA1 [nucleoplasm] (R-SCE-5082367-2) SSA1 [nucleoplasm] (R-SCE-5252082-2) SSA1 [nucleoplasm] (R-SCE-5252088-2) SSA1 [nucleoplasm] (R-SCE-5252047-2) SSA1 [cytosol] (R-SCE-3371410-2) SSA1 [cytosol] (R-SCE-5251948-2) SSA1 [cytosol] (R-SCE-3371408-2) SSA1 [cytosol] (R-SCE-3371521-2) SSA1 [cytosol] (R-SCE-5251954-2) SSA1 [cytosol] (R-SCE-6792602-2) SSA1 [nucleoplasm] (R-SCE-8932217-2)	0.527	3
UniProt:Q00362	1	CDC55 [cytosol] (R-SCE-377253)	0.527	2
UniProt:Q03330	2	GCN5 [nucleoplasm] (R-SCE-3006516) GCN5 [nucleoplasm] (R-SCE-352430)	0.527	3
UniProt:P05317	1	RPP0 [cytosol] (R-SCE-72396)	0.508	2
UniProt:P52286	2	SKP1 [nucleoplasm] (R-SCE-187538) SKP1 [cytosol] (R-SCE-174150)	0.499	2

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