Reactome | diphthine EFT1 [cytosol]

diphthine EFT1 [cytosol]

Stable Identifier

R-SCE-5367015

Type

Protein [EntityWithAccessionedSequence]

Species

Saccharomyces cerevisiae

Compartment

cytosol

Synonyms

diphthine Elongation factor 2

Literature References

PubMed ID	Title	Journal	Year
24739148	Dph7 catalyzes a previously unknown demethylation step in diphthamide biosynthesis Chen, W, Ci, B, Zhang, S, Su, X, Lin, Z, Lin, H	J. Am. Chem. Soc.	2014

External Reference Information

External Reference

UniProt:P32324 EFT1

Gene Names

EFT1, YOR133W, O3317, YOR3317W, EFT2, YDR385W

Chain

chain:1-842

Reference Genes

BioGPS Gene:851993 EFT1

BioGPS Gene:854301 EFT1

KEGG:sce:YDR385W EFT1

KEGG:sce:YOR133W EFT1

Monarch:851993 EFT1

Monarch:854301 EFT1

NCBI Gene:851993 EFT1

NCBI Gene:854301 EFT1

UCSC:P32324 EFT1

Reference Transcript

Other Identifiers

1777413_s_at

8425_s_at

851993

854301

GO:0000166

GO:0003674

GO:0003723

GO:0003746

GO:0003924

GO:0005515

GO:0005525

GO:0005575

GO:0005737

GO:0005829

GO:0006412

GO:0006414

GO:0006417

GO:0008135

GO:0008150

GO:0016787

GO:0019843

GO:0042802

GO:0043022

GO:0043167

GO:0045901

GO:0051087

GO:1990145

GO:1990904

Participates

as an output of

Diphthamide biosynthesis protein 7 hydrolyzes a methyl group on Me-diphthine elongation factor 2 (Saccharomyces cerevisiae)

Other forms of this molecule

EEF2 [ficolin-1-rich granule lumen]

EEF2 [extracellular region]

EEF2 [secretory granule lumen]

EEF2 [cytosol]

aminocarboxypropyl EEF2 [cytosol]

Me-diphthine EEF2 [cytosol]

nascent EEF2 [cytosol]

diphthine EEF2 [cytosol]

Me-diphthine EFT1 [cytosol]

Me3K525-EEF2 [cytosol]

Modified Residues

Name

modified L-histidine residue (diphthine residue) at 699

Coordinate

699

Modification

diphthine residue

PsiMod Name

modified L-histidine residue

PsiMod Definition

A protein modification that modifies an L-histidine residue.

Cross References

ENSEMBL

YOR133W, YDR385W, YOR133W, YOR133W_mRNA, YDR385W_mRNA, YDR385W

PRO

P32324

PDB

3DNY, 5JUS, 5JUO, 5JUP, 3B8H, 2P8Z, 2P8W, 2P8Y, 2P8X, 8EWB, 1N0U, 1U2R, 1N0V, 3B82, 4V4B, 5JUT, 5JUU, 8EUB, 8K2D, 6GQB, 8CDR, 2NPF, 3B78, 6GQ1, 1ZM9, 2E1R, 1ZM4, 8EVR, 8EVQ, 2ZIT, 6GQV, 1ZM2, 1ZM3, 8EVS

Interactors (22)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P48362 HGH1			0.78	9
UniProt:P40487	1	DPH1 [cytosol] (R-SCE-5358384)	0.704	25
UniProt:P32324 EFT1	11	EEF2 [ficolin-1-rich granule lumen] (R-SCE-6801513) EEF2 [extracellular region] (R-SCE-6806499) EEF2 [secretory granule lumen] (R-SCE-6801504) EEF2 [cytosol] (R-SCE-156901) aminocarboxypropyl EEF2 [cytosol] (R-SCE-5358478) Me-diphthine EEF2 [cytosol] (R-SCE-5367025) nascent EEF2 [cytosol] (R-SCE-5358472) diphthine EEF2 [cytosol] (R-SCE-5358501) Me-diphthine EFT1 [cytosol] (R-SCE-5367013) diphthine EFT1 [cytosol] (R-SCE-5367015) Me3K525-EEF2 [cytosol] (R-SCE-8932237)	0.678	59
UniProt:P32461	1	DPH2 [cytosol] (R-SCE-5358368)	0.678	27
UniProt:P42842 EMW1			0.659	5
UniProt:P05317	1	RPP0 [cytosol] (R-SCE-72396)	0.622	3
UniProt:P32469	1	DPH5 [cytosol] (R-SCE-5358485)	0.595	3
UniProt:P40150	17	HSPA6 [cytosol] (R-SCE-3371521-6) HSPA13 [cytosol] (R-SCE-5251981-6) HSPA14 [cytosol] (R-SCE-5251948-6) HSPA13 [nucleoplasm] (R-SCE-5252009-6) HSPA6 [nucleoplasm] (R-SCE-5252088-6) HSPA14 [nucleoplasm] (R-SCE-5252082-6) HSPA1L [nucleoplasm] (R-SCE-5082367-6) HSPA2 [nucleoplasm] (R-SCE-912480-6) HSPA1A [nucleoplasm] (R-SCE-6792605-6) HSPA6 [secretory granule lumen] (R-SCE-6801472-6) HSPA6 [extracellular region] (R-SCE-6806500-6) HSPA1A [extracellular region] (R-SCE-6805872-6) HSPA1A [ficolin-1-rich granule lumen] (R-SCE-6801496-6) HSPA6 [ficolin-1-rich granule lumen] (R-SCE-6801512-6) HSPA1A [cytosol] (R-SCE-6792602-6) HSPA2 [cytosol] (R-SCE-3371408-6) HSPA1L [cytosol] (R-SCE-3371410-6)	0.564	2
UniProt:Q02821	2	SRP1 [cytosol] (R-SCE-180612) SRP1 [cytosol] (R-SCE-9734672)	0.564	2
UniProt:P41940 MPG1			0.547	2
UniProt:P38011	1	ASC1 [cytosol] (R-SCE-5626956)	0.528	2
UniProt:P32905 RPS0A	3	RPS0A [cytosol] (R-SCE-72389) RPS0A [cytosol] (R-SCE-9633103) RPS0A [nucleoplasm] (R-SCE-6798722)	0.528	2
UniProt:P10592	20	SSA2 [cytosol] (R-SCE-264476) SSA2 [nucleoplasm] (R-SCE-5082380) SSA2 [cytosol] (R-SCE-3371410-3) SSA2 [cytosol] (R-SCE-3371408-3) SSA2 [cytosol] (R-SCE-6792602-3) SSA2 [ficolin-1-rich granule lumen] (R-SCE-6801512-3) SSA2 [ficolin-1-rich granule lumen] (R-SCE-6801496-3) SSA2 [ficolin-1-rich granule lumen] (R-SCE-6801494) SSA2 [extracellular region] (R-SCE-6805872-3) SSA2 [extracellular region] (R-SCE-6806500-3) SSA2 [extracellular region] (R-SCE-6805936) SSA2 [secretory granule lumen] (R-SCE-6801530) SSA2 [secretory granule lumen] (R-SCE-6801472-3) SSA2 [nucleoplasm] (R-SCE-6792605-3) SSA2 [nucleoplasm] (R-SCE-912480-3) SSA2 [nucleoplasm] (R-SCE-5082367-3) SSA2 [nucleoplasm] (R-SCE-5252082-3) SSA2 [nucleoplasm] (R-SCE-5252088-3) SSA2 [nucleoplasm] (R-SCE-5252009-3) SSA2 [cytosol] (R-SCE-5251948-3)	0.527	3
UniProt:P25491	3	SOH-C149,C150-DNAJA1 [cytosol] (R-SCE-9857072) DNAJA4 [cytosol] (R-SCE-3371578) DNAJA2 [cytosol] (R-SCE-3371555)	0.527	4
UniProt:P35184	1	SQT1 [cytosol] (R-SCE-9674636)	0.527	3
UniProt:P39077	1	CCT3 [cytosol] (R-SCE-390463)	0.527	3
UniProt:Q03330	2	KAT2B [nucleoplasm] (R-SCE-352430) KAT2A [nucleoplasm] (R-SCE-3006516)	0.527	3
UniProt:Q00362	2	CDC55 [cytosol] (R-SCE-377253) CDC55 [nucleoplasm] (R-SCE-1564978)	0.527	2
UniProt:P10591	17	SSA1 [cytosol] (R-SCE-3371410-2) SSA1 [cytosol] (R-SCE-3371408-2) SSA1 [cytosol] (R-SCE-6792602-2) SSA1 [ficolin-1-rich granule lumen] (R-SCE-6801512-2) SSA1 [ficolin-1-rich granule lumen] (R-SCE-6801496-2) SSA1 [extracellular region] (R-SCE-6805872-2) SSA1 [extracellular region] (R-SCE-6806500-2) SSA1 [secretory granule lumen] (R-SCE-6801472-2) SSA1 [nucleoplasm] (R-SCE-6792605-2) SSA1 [nucleoplasm] (R-SCE-912480-2) SSA1 [nucleoplasm] (R-SCE-5082367-2) SSA1 [nucleoplasm] (R-SCE-5252082-2) SSA1 [nucleoplasm] (R-SCE-5252088-2) SSA1 [nucleoplasm] (R-SCE-5252009-2) SSA1 [cytosol] (R-SCE-5251948-2) SSA1 [cytosol] (R-SCE-5251981-2) SSA1 [cytosol] (R-SCE-3371521-2)	0.527	3
UniProt:P40413	1	CCT5 [cytosol] (R-SCE-390447)	0.527	3
UniProt:P52286	2	SKP1 [cytosol] (R-SCE-174150) SKP1 [nucleoplasm] (R-SCE-187538)	0.499	2
UniProt:P14120 RPL30	2	RPL30 [cytosol] (R-SCE-72452) RPL30 [cytosol] (R-SCE-9633100)	0.46	2

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