Reactome | diphthine EFT1 [cytosol]

diphthine EFT1 [cytosol]

Stable Identifier

R-SCE-5367015

Type

Protein [EntityWithAccessionedSequence]

Species

Saccharomyces cerevisiae

Compartment

cytosol

Synonyms

diphthine Elongation factor 2

Literature References

PubMed ID	Title	Journal	Year
24739148	Dph7 catalyzes a previously unknown demethylation step in diphthamide biosynthesis Lin, Z, Su, X, Chen, W, Ci, B, Zhang, S, Lin, H	J. Am. Chem. Soc.	2014

External Reference Information

External Reference

UniProt:P32324 EFT1

Gene Names

EFT1, YOR133W, O3317, YOR3317W, EFT2, YDR385W

Chain

chain:1-842

Reference Genes

BioGPS Gene:851993 EFT1

BioGPS Gene:854301 EFT1

KEGG Gene (Saccharomyces cerevisiae (strain RM11-1a)):YDR385W EFT1

KEGG Gene (Saccharomyces cerevisiae (strain RM11-1a)):YOR133W EFT1

Monarch:851993 EFT1

Monarch:854301 EFT1

NCBI Gene:851993 EFT1

NCBI Gene:854301 EFT1

Reference Transcript

Other Identifiers

1N0U

1N0V

1U2R

1ZM2

1ZM3

1ZM4

1ZM9

2E1R

2NPF

2P8W

2P8X

2P8Y

2P8Z

2ZIT

3B78

3B82

3B8H

3DNY

4932.YOR133W

4V4B

5JUO

5JUP

5JUS

5JUT

5JUU

AAA21646.1

AAA51398.1

AAB64821.1

AAB64827.1

AAT12549.1

CAA62116.1

CAA64052.1

CAA99332.1

DAA10907.1

DAA12229.1

EntrezGene:851993

EntrezGene:854301

GO:0003674

GO:0003723

GO:0003746

GO:0003924

GO:0005525

GO:0005575

GO:0005737

GO:0005829

GO:0006414

GO:0006417

GO:0008135

GO:0008150

GO:0016787

GO:0019843

GO:0043167

GO:0045901

GO:1990145

IPR000640

IPR000795

IPR004161

IPR005225

IPR005517

IPR009000

IPR014721

IPR020568

IPR027417

IPR031157

IPR035647

IPR041095

NM_001180693.1

NM_001183552.1

NP_010673.1

NP_014776.1

PF00009

PF00679

PF03144

PF03764

PF14492

PR00315

SM00838

SM00889

UPI00000534E7

YDR385W

YDR385W_mRNA

YOR133W

YOR133W_mRNA

Participant Of

output

Diphthamide biosynthesis protein 7 hydrolyzes a methyl group on Me-diphthine elongation factor 2

Other forms of this molecule

Me3K525-EEF2 [cytosol]

nascent EEF2 [cytosol]

aminocarboxypropyl EEF2 [cytosol]

Me-diphthine EFT1 [cytosol]

Me-diphthine EEF2 [cytosol]

EEF2 [ficolin-1-rich granule lumen]

EEF2 [extracellular region]

EEF2 [secretory granule lumen]

EEF2 [cytosol]

diphthine EEF2 [cytosol]

Modified Residues

Name

modified L-histidine residue (diphthine residue) at 699

Coordinate

699

Modification

diphthine residue

PsiMod Name

modified L-histidine residue

PsiMod Definition

A protein modification that modifies an L-histidine residue.

Cross References

RefSeq

NP_010673.1, NP_014776.1

PRO

P32324

PDB

2P8W, 6GQ1, 1ZM4, 2P8X, 1U2R, 2NPF, 1N0V, 6GQV, 2ZIT, 3B78, 2E1R, 5JUT, 3B8H, 4V4B, 3DNY, 5JUU, 1ZM9, 5JUP, 5JUS, 1ZM3, 2P8Y, 1ZM2, 3B82, 2P8Z, 1N0U, 6GQB, 5JUO

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P48362 HGH1			0.715	7
UniProt:P40487	1	DPH1 [cytosol] (R-SCE-5358384)	0.611	23
UniProt:P32469	1	DPH5 [cytosol] (R-SCE-5358485)	0.595	3
UniProt:P32461	1	DPH2 [cytosol] (R-SCE-5358368)	0.573	25
UniProt:P32324 EFT1	11	nascent EEF2 [cytosol] (R-SCE-5358472) Me3K525-EEF2 [cytosol] (R-SCE-8932237) aminocarboxypropyl EEF2 [cytosol] (R-SCE-5358478) diphthine EFT1 [cytosol] (R-SCE-5367015) Me-diphthine EFT1 [cytosol] (R-SCE-5367013) Me-diphthine EEF2 [cytosol] (R-SCE-5367025) EEF2 [ficolin-1-rich granule lumen] (R-SCE-6801513) EEF2 [extracellular region] (R-SCE-6806499) EEF2 [secretory granule lumen] (R-SCE-6801504) EEF2 [cytosol] (R-SCE-156901) diphthine EEF2 [cytosol] (R-SCE-5358501)	0.573	58
UniProt:Q02821	2	KPNA2 [cytosol] (R-SCE-205976) KPNA1 [cytosol] (R-SCE-180612)	0.564	2
UniProt:P40150	23	HSPA1A [cytosol] (R-SCE-6792602-7) Me3K561-HSPA8 [nucleoplasm] (R-SCE-8932217-7) HSPA7 [cytosol] (R-SCE-5251954-7) HSPA6 [cytosol] (R-SCE-3371521-7) HSPA13 [cytosol] (R-SCE-5251981-7) HSPA2 [cytosol] (R-SCE-3371408-7) HSPA1L [cytosol] (R-SCE-3371410-7) HSPA7 [nucleoplasm] (R-SCE-5252047-7) HSPA13 [nucleoplasm] (R-SCE-5252009-7) HSPA6 [nucleoplasm] (R-SCE-5252088-7) HSPA1A [nucleoplasm] (R-SCE-6792605-7) HSPA1L [nucleoplasm] (R-SCE-5082367-7) HSPA2 [nucleoplasm] (R-SCE-912480-7) HSPA6 [secretory granule lumen] (R-SCE-6801472-7) HSPA8 [secretory granule lumen] (R-SCE-6801530-7) HSPA8 [extracellular region] (R-SCE-6805936-7) HSPA6 [extracellular region] (R-SCE-6806500-7) HSPA1A [extracellular region] (R-SCE-6805872-7) HSPA8 [ficolin-1-rich granule lumen] (R-SCE-6801494-7) HSPA1A [ficolin-1-rich granule lumen] (R-SCE-6801496-7) HSPA6 [ficolin-1-rich granule lumen] (R-SCE-6801512-7) HSPA8 [nucleoplasm] (R-SCE-5082380-7) HSPA8 [cytosol] (R-SCE-264476-7)	0.564	2
UniProt:P41940 MPG1			0.547	2
UniProt:P42842 EMW1			0.547	3
UniProt:P10591	23	HSPA8 [nucleoplasm] (R-SCE-5082380-2) HSPA8 [cytosol] (R-SCE-264476-2) HSPA6 [ficolin-1-rich granule lumen] (R-SCE-6801512-2) HSPA1A [ficolin-1-rich granule lumen] (R-SCE-6801496-2) HSPA8 [ficolin-1-rich granule lumen] (R-SCE-6801494-2) HSPA1A [extracellular region] (R-SCE-6805872-2) HSPA6 [extracellular region] (R-SCE-6806500-2) HSPA8 [extracellular region] (R-SCE-6805936-2) HSPA8 [secretory granule lumen] (R-SCE-6801530-2) HSPA6 [secretory granule lumen] (R-SCE-6801472-2) HSPA2 [nucleoplasm] (R-SCE-912480-2) HSPA1L [nucleoplasm] (R-SCE-5082367-2) HSPA1A [nucleoplasm] (R-SCE-6792605-2) HSPA6 [nucleoplasm] (R-SCE-5252088-2) HSPA13 [nucleoplasm] (R-SCE-5252009-2) HSPA7 [nucleoplasm] (R-SCE-5252047-2) HSPA1L [cytosol] (R-SCE-3371410-2) HSPA2 [cytosol] (R-SCE-3371408-2) HSPA13 [cytosol] (R-SCE-5251981-2) HSPA6 [cytosol] (R-SCE-3371521-2) HSPA7 [cytosol] (R-SCE-5251954-2) HSPA1A [cytosol] (R-SCE-6792602-2) Me3K561-HSPA8 [nucleoplasm] (R-SCE-8932217-2)	0.527	3
UniProt:Q00362	2	PPP2R2A [nucleoplasm] (R-SCE-1564978) PPP2R2A [cytosol] (R-SCE-377253)	0.527	2
UniProt:Q03330	2	KAT2A [nucleoplasm] (R-SCE-3006516) KAT2B [nucleoplasm] (R-SCE-352430)	0.527	3
UniProt:P05317	1	RPLP0 [cytosol] (R-SCE-72396)	0.508	2
UniProt:P52286	2	SKP1 [nucleoplasm] (R-SCE-187538) SKP1 [cytosol] (R-SCE-174150)	0.499	2