Reactome | HHF2 [nucleoplasm]

HHF2 [nucleoplasm]

Stable Identifier

R-SCE-5651656

Type

Protein [EntityWithAccessionedSequence]

Species

Saccharomyces cerevisiae

Compartment

nucleoplasm

Synonyms

Me3K21-HIST1H4, P02309

External Reference Information

External Reference

UniProt:P02309

Gene Names

HHF2

Reference Genes

BioGPS Gene:852294 HHF2

BioGPS Gene:855701 HHF2

ENSEMBL:YBR009C

KEGG Gene (Saccharomyces cerevisiae (strain RM11-1a)):YBR009C HHF2

KEGG Gene (Saccharomyces cerevisiae (strain RM11-1a)):YNL030W HHF2

Monarch:852294 HHF2

Monarch:855701 HHF2

NCBI Gene:852294 HHF2

NCBI Gene:855701 HHF2

SGD:YBR009C

Reference Transcript

Other Identifiers

1778426_s_at

852294

855701

8911_s_at

GO:0000500

GO:0000786

GO:0000788

GO:0003674

GO:0003677

GO:0005198

GO:0005515

GO:0005575

GO:0005634

GO:0005694

GO:0005730

GO:0006325

GO:0006333

GO:0006334

GO:0006355

GO:0006360

GO:0006366

GO:0008150

GO:0008213

GO:0016570

GO:0018193

GO:0030527

GO:0031298

GO:0032991

GO:0034729

GO:0042393

GO:0042790

GO:0043934

GO:0043935

GO:0045943

GO:0046982

GO:0051321

GO:0061587

Other forms of this molecule

HHF2 [nucleoplasm]

Inferred From

Me3K21-HIST1H4 [nucleoplasm] (Homo sapiens)

Modified Residues

Name

N6,N6,N6-trimethyl-L-lysine at 21 (in Homo sapiens)

Coordinate

PsiMod Name

N6,N6,N6-trimethyl-L-lysine [MOD:00083]

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to N6,N6,N6-trimethyl-L-lysine.

Cross References

RefSeq

NP_009563.1, NP_014368.1

PRO

P02309

PDB

6GEN, 6GEJ, 2DVQ, 2E3K, 4PSX, 5ZBB, 5ZBA, 7Z0O, 2H2H, 3TO6, 7E9F, 8XGC, 7E9C, 6RXR, 7ON1, 6RXQ, 1ID3, 6RXP, 6RXO, 4KUD, 6RXM, 6QLD, 6RXL, 7K7G, 4TWJ, 8OW0, 6RXK, 6RXJ, 8OW1, 5W0V, 2QQG, 2L5A, 1SZD, 1Q1A, 2QQF, 4JJN, 4TWI, 7K78, 2DVR, 1E6I, 7XAY, 1SZC

Interactors (90)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P61830	13	HHT2 [nucleoplasm] (R-SCE-427369) HHT2 [nucleoplasm] (R-SCE-427504) HHT2 [nucleoplasm] (R-SCE-5250654) HHT2 [nucleoplasm] (R-SCE-427324) phospho-HHT2 [nucleoplasm] (R-SCE-5625878) phospho-HHT2 [nucleoplasm] (R-SCE-5625858) HHT2 [nucleoplasm] (R-SCE-5625800) phospho-HHT2 [nucleoplasm] (R-SCE-5625758) HHT2 [nucleoplasm] (R-SCE-5625747) HHT2 [nucleoplasm] (R-SCE-1214216) HHT2 [nucleoplasm] (R-SCE-212282) HHT2 [nucleoplasm] (R-SCE-212295) HHT2 [nucleoplasm] (R-SCE-1214206)	0.921	72
UniProt:P04912	20	HTA2 [nucleoplasm] (R-SCE-6782532-2) HTA2 [nucleoplasm] (R-SCE-6782493-2) HTA2 [nucleoplasm] (R-SCE-6782514-2) HTA2 [nucleoplasm] (R-SCE-6782531-2) HTA2 [nucleoplasm] (R-SCE-4568572-2) HTA2 [nucleoplasm] (R-SCE-4568611-2) HTA2 [nucleoplasm] (R-SCE-4568583-2) HTA2 [nucleoplasm] (R-SCE-4568598-2) HTA2 [nucleoplasm] (R-SCE-5244584-2) HTA2 [nucleoplasm] (R-SCE-5244581-2) HTA2 [nucleoplasm] (R-SCE-5244538-2) HTA2 [nucleoplasm] (R-SCE-5244562-2) HTA2 [nucleoplasm] (R-SCE-5244557-2) HTA2 [nucleoplasm] (R-SCE-5244574-2) HTA2 [nucleoplasm] (R-SCE-5244542-2) HTA2 [nucleoplasm] (R-SCE-5244576-2) HTA2 [nucleoplasm] (R-SCE-5244590-2) HTA2 [nucleoplasm] (R-SCE-5244621-2) HTA2 [nucleoplasm] (R-SCE-5244589-2) HTA2 [nucleoplasm] (R-SCE-5244628-2)	0.839	19
UniProt:Q12373 HIF1			0.809	25
UniProt:P32447	1	ASF1 [nucleoplasm] (R-SCE-417169)	0.809	20
UniProt:Q12161 PSH1			0.802	19
UniProt:P02309	14	HHF2 [nucleoplasm] (R-SCE-4570518) HHF2 [nucleoplasm] (R-SCE-212078) HHF2 [nucleoplasm] (R-SCE-4568744) HHF2 [nucleoplasm] (R-SCE-5229015) HHF2 [nucleoplasm] (R-SCE-4754243) HHF2 [nucleoplasm] (R-SCE-4754240) HHF2 [nucleoplasm] (R-SCE-5651656) HHF2 [nucleoplasm] (R-SCE-427469) HHF2 [nucleoplasm] (R-SCE-4568748) HHF2 [nucleoplasm] (R-SCE-4568758) HHF2 [nucleoplasm] (R-SCE-5423110) HHF2 [nucleoplasm] (R-SCE-3451124) HHF2 [nucleoplasm] (R-SCE-5651652) HHF2 [nucleoplasm] (R-SCE-181902)	0.752	8
UniProt:P32597	1	SMARCA2 [nucleoplasm] (R-SCE-389256-2)	0.748	6
UniProt:P02293	16	HTB1 [nucleoplasm] (R-SCE-6782561) HTB1 [nucleoplasm] (R-SCE-6782554) HTB1 [nucleoplasm] (R-SCE-4549263) HTB1 [nucleoplasm] (R-SCE-4549272) HTB1 [nucleoplasm] (R-SCE-4568624) HTB1 [nucleoplasm] (R-SCE-181898) HTB1 [nucleoplasm] (R-SCE-181916) HTB1 [nucleoplasm] (R-SCE-3364019) HTB1 [nucleoplasm] (R-SCE-3364020) HTB1 [nucleoplasm] (R-SCE-4568637) HTB1 [nucleoplasm] (R-SCE-4568639) HTB1 [nucleoplasm] (R-SCE-4568629) HTB1 [nucleoplasm] (R-SCE-4568632) HTB1 [nucleoplasm] (R-SCE-4568647) HTB1 [nucleoplasm] (R-SCE-4568631) HTB1 [nucleoplasm] (R-SCE-4568615)	0.744	4
UniProt:P40161 RT106			0.744	10
UniProt:P15790 CKA1	5	CKA1 [nucleoplasm] (R-SCE-6790643) CSNK2A1 [nucleoplasm] (R-SCE-6805057) CSNK2A2 [nucleoplasm] (R-SCE-6805065) CSNK2A2 [cytosol] (R-SCE-201721) CSNK2A1 [cytosol] (R-SCE-201713)	0.744	5
UniProt:Q12341	1	HAT1 [nucleoplasm] (R-SCE-3662337)	0.744	29
UniProt:P39984	1	HAT2 [nucleoplasm] (R-SCE-212227)	0.744	17
UniProt:P32558	1	SPT16 [nucleoplasm] (R-SCE-112415)	0.744	18
UniProt:Q04636	1	POB3 [nucleoplasm] (R-SCE-65105)	0.744	12
UniProt:Q06205 FKBP4			0.678	5
UniProt:P02294	16	HTB2 [nucleoplasm] (R-SCE-181898-2) HTB2 [nucleoplasm] (R-SCE-181916-2) HTB2 [nucleoplasm] (R-SCE-3364019-2) HTB2 [nucleoplasm] (R-SCE-3364020-2) HTB2 [nucleoplasm] (R-SCE-4568637-2) HTB2 [nucleoplasm] (R-SCE-4568639-2) HTB2 [nucleoplasm] (R-SCE-4568629-2) HTB2 [nucleoplasm] (R-SCE-4568632-2) HTB2 [nucleoplasm] (R-SCE-4568647-2) HTB2 [nucleoplasm] (R-SCE-4568631-2) HTB2 [nucleoplasm] (R-SCE-4568615-2) HTB2 [nucleoplasm] (R-SCE-4568624-2) HTB2 [nucleoplasm] (R-SCE-4549272-2) HTB2 [nucleoplasm] (R-SCE-4549263-2) HTB2 [nucleoplasm] (R-SCE-6782554-2) HTB2 [nucleoplasm] (R-SCE-6782561-2)	0.669	9
UniProt:Q12510 CMR1			0.669	4
UniProt:P11746	2	phospho-MCM1 [nucleoplasm] (R-SCE-9612518) MCM1 [nucleoplasm] (R-SCE-5666000)	0.669	3
UniProt:Q08649	1	KAT5 [nucleoplasm] (R-SCE-3321979)	0.667	5
UniProt:P32657 CHD1			0.643	4
UniProt:P43639 CKB1	1	CKB1 [nucleoplasm] (R-SCE-6790659)	0.643	3
UniProt:P43596 IOC3			0.643	4
UniProt:Q12692	1	HTZ1 [nucleoplasm] (R-SCE-8862427)	0.643	6
UniProt:P43609	2	SMARCC1 [nucleoplasm] (R-SCE-389257) SMARCC2 [nucleoplasm] (R-SCE-389263-2)	0.643	4
UniProt:P34218 SAS3			0.643	5
UniProt:P38144 ISW1			0.643	4
UniProt:Q06639 RSC3			0.643	6
UniProt:Q04779 RCO1			0.643	4
UniProt:Q12432 EAF3			0.643	4
UniProt:Q05123	3	ARP9 [extracellular region] (R-SCE-350725) ARP9 [cytosol] (R-SCE-201861) ARP9 [plasma membrane] (R-SCE-196016)	0.638	4
UniProt:Q02486	7	phospho-ABF2 [mitochondrial matrix] (R-SCE-9838277-3) ABF2 [mitochondrial matrix] (R-SCE-163312-3) ABF2 [secretory granule lumen] (R-SCE-6803337-3) ABF2 [ficolin-1-rich granule lumen] (R-SCE-6803291-3) ABF2 [extracellular region] (R-SCE-879382-3) ABF2 [nucleoplasm] (R-SCE-266221-3) ABF2 [extracellular region] (R-SCE-6797422-3)	0.628	8
UniProt:Q00362	2	CDC55 [cytosol] (R-SCE-377253) CDC55 [nucleoplasm] (R-SCE-1564978)	0.592	4
UniProt:P38890	2	SET5 [nucleoplasm] (R-SCE-5637688) SET5 [nucleoplasm] (R-SCE-3222233)	0.59	3
UniProt:P47050 CUL8			0.589	2
UniProt:P40513	1	MAM33 [cytosol] (R-SCE-9645690)	0.564	4
UniProt:P38630	1	RFC1 [nucleoplasm] (R-SCE-68435)	0.564	5
UniProt:Q03973	8	phospho-HMO1 [mitochondrial matrix] (R-SCE-9838277-5) HMO1 [mitochondrial matrix] (R-SCE-163312-5) HMO1 [secretory granule lumen] (R-SCE-6803337-5) HMO1 [ficolin-1-rich granule lumen] (R-SCE-6803291-5) HMO1 [nucleoplasm] (R-SCE-266211) HMO1 [extracellular region] (R-SCE-879382-5) HMO1 [nucleoplasm] (R-SCE-266221-5) HMO1 [extracellular region] (R-SCE-6797422-5)	0.564	3
UniProt:P35817 BDF1			0.564	3
UniProt:P36124 SET3			0.564	2
UniProt:P38826 ORC6	1	yORC6 [nucleoplasm] (R-SCE-9749321)	0.564	2
UniProt:P53330 RT102			0.564	4
UniProt:P54784 ORC1	6	ORC1 [nucleoplasm] (R-SCE-68522) yORC1 [nucleoplasm] (R-SCE-9749323) ORC1 [cytosol] (R-SCE-113840) phospho-p-S,T-ORC1 [nucleoplasm] (R-SCE-68943) phospho-PolyUb,p-S,T-ORC1 [nucleoplasm] (R-SCE-9032189) phospho-PolyUb,p-S,T-ORC1 [cytosol] (R-SCE-9032195)	0.564	2
UniProt:P32833 ORC2	2	yORC2 [nucleoplasm] (R-SCE-9749316) ORC2 [nucleoplasm] (R-SCE-68405)	0.564	2
UniProt:Q9Y294 ASF1A	1	ASF1A [nucleoplasm] (R-HSA-417169)	0.556	3
UniProt:Q02206 RSC4			0.527	4
UniProt:P32333 BTAF1			0.527	2
UniProt:P31244 RAD16			0.527	3
UniProt:Q07979 RSC58			0.527	4
UniProt:P33748 MSN2			0.527	2
UniProt:Q06488	1	RSC2 [nucleoplasm] (R-SCE-389254)	0.527	2
UniProt:P25632	2	RSC6 [nucleoplasm] (R-SCE-5225626) RSC6 [nucleoplasm] (R-SCE-400141)	0.527	3
UniProt:Q12406	2	ARP7 [nucleoplasm] (R-SCE-5225616) ARP7 [nucleoplasm] (R-SCE-2980912-2)	0.527	3
UniProt:Q04199 CAC2			0.527	3
UniProt:P53741 BRE5			0.527	2
UniProt:P23615	1	SPT6 [nucleoplasm] (R-SCE-8932908)	0.527	3
UniProt:Q03940 RUVB1			0.527	2
UniProt:Q06188 YL455			0.527	4
UniProt:Q9URQ5 HTL1			0.527	2
UniProt:P05317	1	RPP0 [cytosol] (R-SCE-72396)	0.527	3
UniProt:P38930 CKB2	6	CKB2 [nucleoplasm] (R-SCE-6790709) CKB2 [secretory granule lumen] (R-SCE-6801319) CKB2 [extracellular region] (R-SCE-6806508) CKB2 [ficolin-1-rich granule lumen] (R-SCE-6801290) CKB2 [nucleoplasm] (R-SCE-6805067) CKB2 [cytosol] (R-SCE-201693)	0.527	2
UniProt:Q12072 IOC2			0.527	3
UniProt:P32832 RSC7			0.527	3
UniProt:Q07442 BDF2			0.527	3
UniProt:P11938 RAP1			0.527	3
UniProt:P48415	2	SEC16 [cytosol] (R-SCE-5685728) SEC16 [cytosol] (R-SCE-5685731)	0.527	2
UniProt:P53883	3	NOP13 [cytosol] (R-SCE-72591-2) phospho-NOP13 [cytosol] (R-SCE-165773-2) NOP13 [cytosol] (R-SCE-72589-2)	0.527	2
UniProt:P46677	2	TAF1 [nucleoplasm] (R-SCE-212435) TAF1 [nucleoplasm] (R-SCE-65539)	0.527	2
UniProt:Q12464 RUVB2			0.527	2
UniProt:P38781 RSC30			0.527	3
UniProt:P32481 GCD11	2	GCD11 [cytosol] (R-SCE-9633596) EIF2S3 [cytosol] (R-SCE-72514)	0.527	2
UniProt:P32480 HIR2			0.527	3
UniProt:P14832 CYPH			0.527	2
UniProt:Q02959 HOS3			0.527	3
UniProt:P40069 IMB4			0.527	3
UniProt:P11484	17	HSPA1L [cytosol] (R-SCE-3371410-4) HSPA2 [cytosol] (R-SCE-3371408-4) HSPA1A [cytosol] (R-SCE-6792602-4) HSPA6 [ficolin-1-rich granule lumen] (R-SCE-6801512-4) HSPA1A [ficolin-1-rich granule lumen] (R-SCE-6801496-4) HSPA1A [extracellular region] (R-SCE-6805872-4) HSPA6 [extracellular region] (R-SCE-6806500-4) HSPA6 [secretory granule lumen] (R-SCE-6801472-4) HSPA1A [nucleoplasm] (R-SCE-6792605-4) HSPA2 [nucleoplasm] (R-SCE-912480-4) HSPA1L [nucleoplasm] (R-SCE-5082367-4) HSPA14 [nucleoplasm] (R-SCE-5252082-4) HSPA6 [nucleoplasm] (R-SCE-5252088-4) HSPA13 [nucleoplasm] (R-SCE-5252009-4) HSPA14 [cytosol] (R-SCE-5251948-4) HSPA13 [cytosol] (R-SCE-5251981-4) HSPA6 [cytosol] (R-SCE-3371521-4)	0.527	3
UniProt:P40340	1	ATAD2 [nucleoplasm] (R-SCE-8937250)	0.527	4
UniProt:P29496 MCM5	2	yMcm5 [nucleoplasm] (R-SCE-169511) MCM5 [nucleoplasm] (R-SCE-68551)	0.527	3
UniProt:Q03761	1	TAF12 [nucleoplasm] (R-SCE-65555)	0.527	2
UniProt:Q03124 RSC9			0.527	3
UniProt:P43572 EPL1			0.527	2
UniProt:P19454 CKA2	5	CKA2 [nucleoplasm] (R-SCE-6790631) CSNK2A1 [nucleoplasm] (R-SCE-6805057-2) CSNK2A2 [nucleoplasm] (R-SCE-6805065-2) CSNK2A2 [cytosol] (R-SCE-201721-2) CSNK2A1 [cytosol] (R-SCE-201713-2)	0.527	3
UniProt:Q05471 SWR1			0.527	2
UniProt:P22579	3	SIN3 [nucleoplasm] (R-SCE-4086071) SIN3 [nucleoplasm] (R-SCE-351657) SIN3 [nucleoplasm] (R-SCE-349685)	0.527	2
UniProt:Q06554	1	HLTF [nucleoplasm] (R-SCE-8855007)	0.527	2
UniProt:P10592	20	SSA2 [cytosol] (R-SCE-264476) SSA2 [nucleoplasm] (R-SCE-5082380) SSA2 [cytosol] (R-SCE-3371410-3) SSA2 [cytosol] (R-SCE-3371408-3) SSA2 [cytosol] (R-SCE-6792602-3) SSA2 [ficolin-1-rich granule lumen] (R-SCE-6801512-3) SSA2 [ficolin-1-rich granule lumen] (R-SCE-6801496-3) SSA2 [ficolin-1-rich granule lumen] (R-SCE-6801494) SSA2 [extracellular region] (R-SCE-6805872-3) SSA2 [extracellular region] (R-SCE-6806500-3) SSA2 [extracellular region] (R-SCE-6805936) SSA2 [secretory granule lumen] (R-SCE-6801530) SSA2 [secretory granule lumen] (R-SCE-6801472-3) SSA2 [nucleoplasm] (R-SCE-6792605-3) SSA2 [nucleoplasm] (R-SCE-912480-3) SSA2 [nucleoplasm] (R-SCE-5082367-3) SSA2 [nucleoplasm] (R-SCE-5252082-3) SSA2 [nucleoplasm] (R-SCE-5252088-3) SSA2 [nucleoplasm] (R-SCE-5252009-3) SSA2 [cytosol] (R-SCE-5251948-3)	0.527	3
UniProt:P53091 MCM6	2	yMcm6 [nucleoplasm] (R-SCE-169504) MCM6 [nucleoplasm] (R-SCE-68553)	0.527	2
UniProt:P27692	1	phospho-SPT5 [nucleoplasm] (R-SCE-3009372)	0.527	4
UniProt:Q01477	2	UBP3 [nucleoplasm] (R-SCE-3222218) UBP3 [cytosol] (R-SCE-6782974)	0.527	2
UniProt:P36012	20	CSE4 [nucleoplasm] (R-SCE-427507) CSE4 [nucleoplasm] (R-SCE-4551293) CSE4 [nucleoplasm] (R-SCE-4551291) CSE4 [nucleoplasm] (R-SCE-4551292) CSE4 [nucleoplasm] (R-SCE-5229052) CSE4 [nucleoplasm] (R-SCE-5229062) CSE4 [nucleoplasm] (R-SCE-5211328) CSE4 [nucleoplasm] (R-SCE-5218935) CSE4 [nucleoplasm] (R-SCE-4754193) CSE4 [nucleoplasm] (R-SCE-4722135) CSE4 [nucleoplasm] (R-SCE-5649791) CSE4 [nucleoplasm] (R-SCE-5649795) CSE4 [nucleoplasm] (R-SCE-5649768) CSE4 [nucleoplasm] (R-SCE-5638160) CSE4 [nucleoplasm] (R-SCE-4722125) CSE4 [nucleoplasm] (R-SCE-212105) CSE4 [nucleoplasm] (R-SCE-5638327) CSE4 [cytosol] (R-SCE-8943830) CSE4 [cytosol] (R-SCE-8943831) CSE4 [nucleoplasm] (R-SCE-5244526)	0.524	2
UniProt:P37898 AAP1			0.508	2