Reactome | ISG-K164,ISG-K168-PCNA [nucleoplasm]

ISG-K164,ISG-K168-PCNA [nucleoplasm]

Stable Identifier

R-SCE-5653768

Type

Protein [EntityWithAccessionedSequence]

Species

Saccharomyces cerevisiae

Compartment

nucleoplasm

Synonyms

P15873

Locations in the PathwayBrowser

Expand all

DNA Repair (Saccharomyces cerevisiae)

- DNA Damage Bypass (Saccharomyces cerevisiae)
  - Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template (Saccharomyces cerevisiae)
    - Termination of translesion DNA synthesis (Saccharomyces cerevisiae)
      - USP10 binds monoUb:K164,ISG:K164,ISG:K168-PCNA (Saccharomyces cerevisiae)
        
        DNA polymerase Y:MonoUb:K164,ISG:K164,ISG:K168-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] (Saccharomyces cerevisiae)
        
        MonoUb:K164,ISG:K164,ISG:K168-PCNA homotrimer [nucleoplasm] (Saccharomyces cerevisiae)
        
        ISG:K164,ISG:K168-PCNA [nucleoplasm] (Saccharomyces cerevisiae)
        
        ISG-K164,ISG-K168-PCNA [nucleoplasm] (Saccharomyces cerevisiae)
        
        USP10:DNA polymerase Y:MonoUb:K164,ISG:K164,ISG:K168-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] (Saccharomyces cerevisiae)
        
        DNA polymerase Y:MonoUb:K164,ISG:K164,ISG:K168-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] (Saccharomyces cerevisiae)
        
        MonoUb:K164,ISG:K164,ISG:K168-PCNA homotrimer [nucleoplasm] (Saccharomyces cerevisiae)
        
        ISG:K164,ISG:K168-PCNA [nucleoplasm] (Saccharomyces cerevisiae)
        
        ISG-K164,ISG-K168-PCNA [nucleoplasm] (Saccharomyces cerevisiae)
      - USP43 binds ISG:K164,ISG:K168-PCNA (Saccharomyces cerevisiae)
        
        ISG:K164,ISG:K168-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] (Saccharomyces cerevisiae)
        
        ISG:K164,ISG:K168-PCNA homotrimer [nucleoplasm] (Saccharomyces cerevisiae)
        
        ISG:K164,ISG:K168-PCNA [nucleoplasm] (Saccharomyces cerevisiae)
        
        ISG-K164,ISG-K168-PCNA [nucleoplasm] (Saccharomyces cerevisiae)
        
        USP43:ISG:K164,ISG:K168-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] (Saccharomyces cerevisiae)
        
        ISG:K164,ISG:K168-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] (Saccharomyces cerevisiae)
        
        ISG:K164,ISG:K168-PCNA homotrimer [nucleoplasm] (Saccharomyces cerevisiae)
        
        ISG:K164,ISG:K168-PCNA [nucleoplasm] (Saccharomyces cerevisiae)
        
        ISG-K164,ISG-K168-PCNA [nucleoplasm] (Saccharomyces cerevisiae)

External Reference Information

External Reference

UniProt:P15873

Reference Genes

BioGPS Gene:852385

ENSEMBL:YBR088C

KEGG Gene (Saccharomyces cerevisiae (strain RM11-1a)):YBR088C

Monarch:852385

NCBI Gene:852385

SGD:YBR088C

Reference Transcript

RefSeq:NM_001178436.1

Other Identifiers

1PLQ

1PLR

1SXJ

2OD8

3F1W

3GPM

3GPN

3L0W

3L0X

3L10

3PGE

3V60

3V61

3V62

4932.YBR088C

4L60

4L6P

4YHR

5JNE

5T9D

6B8I

AAS56041.1

CAA34664.1

CAA55594.1

CAA85038.1

DAA07209.1

EntrezGene:852385

GO:0000278

GO:0000710

GO:0000781

GO:0003674

GO:0003677

GO:0005575

GO:0005634

GO:0005657

GO:0005694

GO:0006260

GO:0006272

GO:0006273

GO:0006275

GO:0006281

GO:0006289

GO:0006298

GO:0006301

GO:0006325

GO:0006348

GO:0006974

GO:0007059

GO:0007064

GO:0008150

GO:0030234

GO:0030337

GO:0030466

GO:0034087

GO:0035753

GO:0042802

GO:0043626

GO:0048285

GO:0051052

GO:0051321

GO:0070987

GO:1902394

GO:1903022

IPR000730

IPR022648

IPR022649

IPR022659

NM_001178436.1

NP_009645.1

PF00705

PF02747

PR00339

UPI0000112986

YBR088C

YBR088C_mRNA

Participant Of

hasComponent

ISG:K164,ISG:K168-PCNA [nucleoplasm]

Other forms of this molecule

SUMO1-K164,K254,K-PCNA [nucleoplasm]

PCNA [nucleoplasm]

MonoUb-K164-PCNA [nucleoplasm]

Inferred From

ISG-K164,ISG-K168-PCNA [nucleoplasm] (Homo sapiens)

Modified Residues

Name

Inter-chain Crosslink via N6-glycyl-L-lysine at 164 and 157 (in Homo sapiens)

Coordinate

164

PsiMod Name

N6-glycyl-L-lysine

PsiMod Definition

A protein modification that effectively crosslinks an L-lysine residue and a glycine residue by an isopeptide bond to form N6-glycyl-L-lysine.

Name

Inter-chain Crosslink via N6-glycyl-L-lysine at 168 and 157 (in Homo sapiens)

Coordinate

168

PsiMod Name

N6-glycyl-L-lysine

PsiMod Definition

A protein modification that effectively crosslinks an L-lysine residue and a glycine residue by an isopeptide bond to form N6-glycyl-L-lysine.

Cross References

RefSeq

NP_009645.1

PRO

P15873

PDB

5V7L, 5ZUT, 6D0R, 5V7M, 6CX4, 3V60, 1SXJ, 5JNE, 4L6P, 6CX2, 4YHR, 6CX3, 1PLQ, 3V62, 1PLR, 3V61, 5T9D, 3F1W, 3PGE, 3L0X, 3GPN, 3L10, 3GPM, 3L0W, 6E49, 5V7K, 2OD8, 6D0Q, 4L60

Interactors (15)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P15873	4	PCNA [nucleoplasm] (R-SCE-68439) SUMO1-K164,K254,K-PCNA [nucleoplasm] (R-SCE-4615861) MonoUb-K164-PCNA [nucleoplasm] (R-SCE-5651986) ISG-K164,ISG-K168-PCNA [nucleoplasm] (R-SCE-5653768)	0.923	10
UniProt:P26793	1	FEN1 [nucleoplasm] (R-SCE-54745)	0.835	8
UniProt:Q04049	1	POLH [nucleoplasm] (R-SCE-110287)	0.783	7
UniProt:P47110 DPOD3			0.766	6
UniProt:P12954 SRS2			0.763	10
UniProt:Q03834	1	MSH6 [nucleoplasm] (R-SCE-5357528)	0.704	5
UniProt:Q12306	30	PIAS4-G97-SUMO1 [nucleoplasm] (R-SCE-3968375) K14-UBE2I-G97-SUMO1 [nucleoplasm] (R-SCE-4085334) K2592-RANBP2-G97-SUMO1 [nuclear envelope] (R-SCE-4551627) ING2-G97-SUMO1 [nucleoplasm] (R-SCE-4086096) DDX17-G97-SUMO1 [nucleoplasm] (R-SCE-3900210) DDX5-G97-SUMO1 [nucleoplasm] (R-SCE-3900212) SIN3A-G97-SUMO1 [nucleoplasm] (R-SCE-4086058) HIPK2-G97-SUMO1 [nucleoplasm] (R-SCE-4090362) TOP2B-G97-SUMO1 [nucleoplasm] (R-SCE-4641311) TOP1-G97-SUMO1 [nucleoplasm] (R-SCE-4641306) TOP2A-G97-SUMO1 [nucleoplasm] (R-SCE-4641341) K-PCNA-G97-SUMO1 [nucleoplasm] (R-SCE-4615836) STAG2-G97-SUMO1 [nucleoplasm] (R-SCE-3826645) RAD21-G97-SUMO1 [nucleoplasm] (R-SCE-3826574) K411-RAD52-G97-SUMO1 [nucleoplasm] (R-SCE-4568857) XPC-G97-SUMO1 [nucleoplasm] (R-SCE-4570452) TP53BP1-G97-SUMO1 [nucleoplasm] (R-SCE-3730731) K289-MITF-G97-SUMO1 [nucleoplasm] (R-SCE-3730738) K114-FOXL2-G97-SUMO1 [nucleoplasm] (R-SCE-3968396) HNRNPC-G97-SUMO1 [nucleoplasm] (R-SCE-4570515) K467-NOP58-G97-SUMO1 [nucleoplasm] (R-SCE-4570462) K444-HDAC1-G97-SUMO1 [nucleoplasm] (R-SCE-4616028) HDAC2-G97-SUMO1 [nucleoplasm] (R-SCE-4616032) SUZ12-G97-SUMO1 [nucleoplasm] (R-SCE-4615961) UBE2I-G97-SUMO1 [nucleoplasm] (R-SCE-3730622) UBA2-G97-SUMO1 [nucleoplasm] (R-SCE-3730616) SUMO1 [nucleoplasm] (R-SCE-877304) SUMO1(2-101) [nucleoplasm] (R-SCE-2990831) HIST1H4-G97-SUMO1 [nucleoplasm] (R-SCE-4570549) HDAC4-G97-SUMO1 [nucleoplasm] (R-SCE-4615956)	0.698	6
UniProt:Q12050 ELG1			0.625	9
UniProt:P12887	1	UNG-1 [nucleoplasm] (R-SCE-5634845)	0.593	4
UniProt:P43605	2	ESCO1 [nucleoplasm] (R-SCE-2466401) ESCO2 [nucleoplasm] (R-SCE-2466400)	0.592	2
UniProt:P32354	1	MCM10 [nucleoplasm] (R-SCE-68403)	0.581	4
UniProt:P30260-2 CDC27			0.556	3
UniProt:P63279 UBE2I	8	SUMO1-C93-UBE2I [cytosol] (R-HSA-4656909) SUMO1-K14-UBE2I [nucleoplasm] (R-HSA-4085358) UBE2I [nuclear envelope] (R-HSA-4655408) UBE2I [cytosol] (R-HSA-4655342) SUMO3-C93-UBE2I [nucleoplasm] (R-HSA-3730629) SUMO2-C93-UBE2I [nucleoplasm] (R-HSA-3730619) UBE2I [nucleoplasm] (R-HSA-912481) SUMO1-C93-UBE2I [nucleoplasm] (R-HSA-3730617)	0.556	3
UniProt:Q12495 RLF2			0.547	3
UniProt:P04819	1	LIG1 [nucleoplasm] (R-SCE-53787)	0.547	2