Reactome | phospho-RAD51 [nucleoplasm]

phospho-RAD51 [nucleoplasm]

Stable Identifier

R-SCE-5685231

Type

Protein [EntityWithAccessionedSequence]

Species

Saccharomyces cerevisiae

Compartment

nucleoplasm

Synonyms

p-T309-RAD51, P25454

Locations in the PathwayBrowser

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DNA Repair (Saccharomyces cerevisiae)

- DNA Double-Strand Break Repair (Saccharomyces cerevisiae)
  - Homology Directed Repair (Saccharomyces cerevisiae)
    - HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Saccharomyces cerevisiae)
      - HDR through Homologous Recombination (HRR) (Saccharomyces cerevisiae)
        
        Homologous DNA Pairing and Strand Exchange (Saccharomyces cerevisiae)
        
        Presynaptic phase of homologous DNA pairing and strand exchange (Saccharomyces cerevisiae)
        
        CHEK1 phosphorylates RAD51 (Saccharomyces cerevisiae)
        
        phospho-RAD51 [nucleoplasm] (Saccharomyces cerevisiae)

External Reference Information

External Reference

UniProt:P25454

Gene Names

RAD51

Reference Genes

BioGPS Gene:856831 RAD51

ENSEMBL:YER095W

KEGG Gene (Saccharomyces cerevisiae (strain YJM789)):YER095W RAD51

Monarch:856831 RAD51

NCBI Gene:856831 RAD51

SGD:YER095W

Reference Transcript

RefSeq:NM_001178986.3 RAD51

Other Identifiers

1773120_at

5626_at

856831

GO:0000150

GO:0000166

GO:0000228

GO:0000278

GO:0000400

GO:0000709

GO:0000722

GO:0000724

GO:0000730

GO:0000794

GO:0003674

GO:0003677

GO:0003690

GO:0003697

GO:0005524

GO:0005575

GO:0005634

GO:0005654

GO:0005694

GO:0006259

GO:0006260

GO:0006281

GO:0006310

GO:0006974

GO:0007131

GO:0008094

GO:0008150

GO:0010212

GO:0016787

GO:0016887

GO:0030491

GO:0032200

GO:0042148

GO:0042802

GO:0043167

GO:0048285

GO:0051321

GO:0070192

GO:1990426

Participant Of

output

CHEK1 phosphorylates RAD51

Other forms of this molecule

RAD51 [nucleoplasm]

Inferred From

p-T309-RAD51 [nucleoplasm] (Homo sapiens)

Modified Residues

Name

O-phospho-L-threonine at 309 (in Homo sapiens)

Coordinate

309

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Cross References

RefSeq

NP_011021.3

OpenTargets

ENSG00000051180

PRO

P25454

PDB

3LDA, 1SZP

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P06778	3	phospho-RAD52 [nucleoplasm] (R-SCE-5686588) RAD52 [nucleoplasm] (R-SCE-4568909) RAD52 [nucleoplasm] (R-SCE-62639)	0.791	16
UniProt:P25454	2	phospho-RAD51 [nucleoplasm] (R-SCE-5685231) RAD51 [nucleoplasm] (R-SCE-62637)	0.692	3
UniProt:P38953	1	RAD55 [nucleoplasm] (R-SCE-217039)	0.667	5
UniProt:P32863 RAD54			0.573	2
UniProt:P02994	6	TEF1 [cytosol] (R-SCE-8932419) TEF1 [cytosol] (R-SCE-8932212) TEF1 [ficolin-1-rich granule lumen] (R-SCE-6801528) TEF1 [extracellular region] (R-SCE-6806456) TEF1 [secretory granule lumen] (R-SCE-6801479) TEF1 [cytosol] (R-SCE-156905)	0.527	2
UniProt:P10592	23	SSA2 [nucleoplasm] (R-SCE-5082380-3) SSA2 [cytosol] (R-SCE-264476-3) SSA2 [secretory granule lumen] (R-SCE-6801530-3) SSA2 [secretory granule lumen] (R-SCE-6801472-3) SSA2 [extracellular region] (R-SCE-6806500-3) SSA2 [extracellular region] (R-SCE-6805936-3) SSA2 [ficolin-1-rich granule lumen] (R-SCE-6801512-3) SSA2 [ficolin-1-rich granule lumen] (R-SCE-6801496-3) SSA2 [ficolin-1-rich granule lumen] (R-SCE-6801494-3) SSA2 [extracellular region] (R-SCE-6805872-3) SSA2 [nucleoplasm] (R-SCE-912480-3) SSA2 [nucleoplasm] (R-SCE-5082367-3) SSA2 [nucleoplasm] (R-SCE-6792605-3) SSA2 [nucleoplasm] (R-SCE-5252082-3) SSA2 [nucleoplasm] (R-SCE-5252088-3) SSA2 [nucleoplasm] (R-SCE-5252047-3) SSA2 [cytosol] (R-SCE-3371410-3) SSA2 [cytosol] (R-SCE-5251948-3) SSA2 [cytosol] (R-SCE-3371408-3) SSA2 [cytosol] (R-SCE-3371521-3) SSA2 [cytosol] (R-SCE-5251954-3) SSA2 [cytosol] (R-SCE-6792602-3) SSA2 [nucleoplasm] (R-SCE-8932217-3)	0.527	2
UniProt:P11484 SSB1			0.527	2
UniProt:P15108	11	HSC82 [ficolin-1-rich granule lumen] (R-SCE-6801491-2) HSC82 [ficolin-1-rich granule lumen] (R-SCE-6801470-2) HSC82 [extracellular region] (R-SCE-6806463-2) HSC82 [extracellular region] (R-SCE-3221946-2) HSC82 [secretory granule lumen] (R-SCE-6801477-2) HSC82 [secretory granule lumen] (R-SCE-6801515-2) HSC82 [plasma membrane] (R-SCE-534996-2) HSC82 [cytosol] (R-SCE-419617-2) HSC82 [nucleoplasm] (R-SCE-5082401-2) HSC82 [nucleoplasm] (R-SCE-5082399-2) HSC82 [cytosol] (R-SCE-192864-2)	0.527	2
UniProt:Q12306	29	SMT3 [nuclear envelope] (R-SCE-4551627) SMT3 [nucleoplasm] (R-SCE-4085334) SMT3 [nucleoplasm] (R-SCE-4086096) SMT3 [nucleoplasm] (R-SCE-3900210) SMT3 [nucleoplasm] (R-SCE-3900212) SMT3 [nucleoplasm] (R-SCE-4086058) SMT3 [nucleoplasm] (R-SCE-4090362) SMT3 [nucleoplasm] (R-SCE-4641311) SMT3 [nucleoplasm] (R-SCE-4641306) SMT3 [nucleoplasm] (R-SCE-4641341) SMT3 [nucleoplasm] (R-SCE-4615836) SMT3 [nucleoplasm] (R-SCE-3826645) SMT3 [nucleoplasm] (R-SCE-3826574) SMT3 [nucleoplasm] (R-SCE-4568857) SMT3 [nucleoplasm] (R-SCE-4570452) SMT3 [nucleoplasm] (R-SCE-3730731) SMT3 [nucleoplasm] (R-SCE-3730738) SMT3 [nucleoplasm] (R-SCE-3968396) SMT3 [nucleoplasm] (R-SCE-4570515) SMT3 [nucleoplasm] (R-SCE-4570462) SMT3 [nucleoplasm] (R-SCE-4616028) SMT3 [nucleoplasm] (R-SCE-4616032) SMT3 [nucleoplasm] (R-SCE-4615956) SMT3 [nucleoplasm] (R-SCE-3730622) SMT3 [nucleoplasm] (R-SCE-3730616) SMT3 [nucleoplasm] (R-SCE-877304) SMT3 [nucleoplasm] (R-SCE-2990831) SMT3 [nucleoplasm] (R-SCE-3730796) SMT3 [nucleoplasm] (R-SCE-4570549)	0.482	2

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