Reactome | TFB1 [nucleoplasm]

TFB1 [nucleoplasm]

Stable Identifier

R-SCE-65912

Type

Protein [EntityWithAccessionedSequence]

Species

Saccharomyces cerevisiae

Compartment

nucleoplasm

Synonyms

GTF2H1, P32776

Locations in the PathwayBrowser

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DNA Repair (Saccharomyces cerevisiae)

- Nucleotide Excision Repair (Saccharomyces cerevisiae)
  - Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Saccharomyces cerevisiae)
    - Dual incision in TC-NER (Saccharomyces cerevisiae)
      - 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Saccharomyces cerevisiae)
        
        TC-NER incision complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Saccharomyces cerevisiae)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Saccharomyces cerevisiae)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Saccharomyces cerevisiae)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Saccharomyces cerevisiae)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Saccharomyces cerevisiae)
        
        TFIIH [nucleoplasm] (Saccharomyces cerevisiae)
        
        TFB1 [nucleoplasm] (Saccharomyces cerevisiae)
        
        TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Saccharomyces cerevisiae)
        
        TFIIH [nucleoplasm] (Saccharomyces cerevisiae)
        
        TFB1 [nucleoplasm] (Saccharomyces cerevisiae)
      - DNA polymerases delta, epsilon or kappa bind the TC-NER site (Saccharomyces cerevisiae)
        
        TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Saccharomyces cerevisiae)
        
        TFIIH [nucleoplasm] (Saccharomyces cerevisiae)
        
        TFB1 [nucleoplasm] (Saccharomyces cerevisiae)
        
        TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Saccharomyces cerevisiae)
        
        TFIIH [nucleoplasm] (Saccharomyces cerevisiae)
        
        TFB1 [nucleoplasm] (Saccharomyces cerevisiae)
      - ERCC2-facilitated RNA Pol II backtracking in TC-NER (Saccharomyces cerevisiae)
        
        TC-NER pre-incision complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Saccharomyces cerevisiae)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Saccharomyces cerevisiae)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Saccharomyces cerevisiae)
        
        TFIIH [nucleoplasm] (Saccharomyces cerevisiae)
        
        TFB1 [nucleoplasm] (Saccharomyces cerevisiae)
        
        TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Saccharomyces cerevisiae)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Partially open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Saccharomyces cerevisiae)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Partially open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Saccharomyces cerevisiae)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Saccharomyces cerevisiae)
        
        TFIIH [nucleoplasm] (Saccharomyces cerevisiae)
        
        TFB1 [nucleoplasm] (Saccharomyces cerevisiae)
      - ERCC3-facilitated RNA Pol II backtracking in TC-NER (Saccharomyces cerevisiae)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Saccharomyces cerevisiae)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Saccharomyces cerevisiae)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Saccharomyces cerevisiae)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Saccharomyces cerevisiae)
        
        TFIIH [nucleoplasm] (Saccharomyces cerevisiae)
        
        TFB1 [nucleoplasm] (Saccharomyces cerevisiae)
        
        TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Saccharomyces cerevisiae)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Partially open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Saccharomyces cerevisiae)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Partially open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Saccharomyces cerevisiae)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Saccharomyces cerevisiae)
        
        TFIIH [nucleoplasm] (Saccharomyces cerevisiae)
        
        TFB1 [nucleoplasm] (Saccharomyces cerevisiae)
    - Formation of TC-NER Pre-Incision Complex (Saccharomyces cerevisiae)
      - Active RNA Pol II complex transcribes lesion-containing DNA template (Saccharomyces cerevisiae)
        
        Damaged dsDNA with open transcription bubble:Hyperphosphorylated RNA Pol II:TFIIH [nucleoplasm] (Saccharomyces cerevisiae)
        
        TFIIH [nucleoplasm] (Saccharomyces cerevisiae)
        
        TFB1 [nucleoplasm] (Saccharomyces cerevisiae)
        
        Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Saccharomyces cerevisiae)
        
        TFIIH [nucleoplasm] (Saccharomyces cerevisiae)
        
        TFB1 [nucleoplasm] (Saccharomyces cerevisiae)
      - ERCC6 binds stalled RNA Pol II (Saccharomyces cerevisiae)
        
        Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Saccharomyces cerevisiae)
        
        TFIIH [nucleoplasm] (Saccharomyces cerevisiae)
        
        TFB1 [nucleoplasm] (Saccharomyces cerevisiae)
        
        Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Saccharomyces cerevisiae)
        
        Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Saccharomyces cerevisiae)
        
        TFIIH [nucleoplasm] (Saccharomyces cerevisiae)
        
        TFB1 [nucleoplasm] (Saccharomyces cerevisiae)
      - ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II (Saccharomyces cerevisiae)
        
        Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Saccharomyces cerevisiae)
        
        Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Saccharomyces cerevisiae)
        
        Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Saccharomyces cerevisiae)
        
        TFIIH [nucleoplasm] (Saccharomyces cerevisiae)
        
        TFB1 [nucleoplasm] (Saccharomyces cerevisiae)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Saccharomyces cerevisiae)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6 [nucleoplasm] (Saccharomyces cerevisiae)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Saccharomyces cerevisiae)
        
        TFIIH [nucleoplasm] (Saccharomyces cerevisiae)
        
        TFB1 [nucleoplasm] (Saccharomyces cerevisiae)
      - RNA Pol II initiates transcription from damaged DNA template (Saccharomyces cerevisiae)
        
        Damaged dsDNA with open transcription bubble:Hyperphosphorylated RNA Pol II:TFIIH [nucleoplasm] (Saccharomyces cerevisiae)
        
        TFIIH [nucleoplasm] (Saccharomyces cerevisiae)
        
        TFB1 [nucleoplasm] (Saccharomyces cerevisiae)
        
        TFIIH [nucleoplasm] (Saccharomyces cerevisiae)
        
        TFB1 [nucleoplasm] (Saccharomyces cerevisiae)
      - UVSSA:USP7 deubiquitinates ERCC6 (Saccharomyces cerevisiae)
        
        TC-NER pre-incision complex [nucleoplasm] (Saccharomyces cerevisiae)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Saccharomyces cerevisiae)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Saccharomyces cerevisiae)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Saccharomyces cerevisiae)
        
        TFIIH [nucleoplasm] (Saccharomyces cerevisiae)
        
        TFB1 [nucleoplasm] (Saccharomyces cerevisiae)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Saccharomyces cerevisiae)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Saccharomyces cerevisiae)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6 [nucleoplasm] (Saccharomyces cerevisiae)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Saccharomyces cerevisiae)
        
        TFIIH [nucleoplasm] (Saccharomyces cerevisiae)
        
        TFB1 [nucleoplasm] (Saccharomyces cerevisiae)
    - Gap-filling DNA repair synthesis and ligation in TC-NER (Saccharomyces cerevisiae)
      - Ligation of newly synthesized repair patch to incised DNA in TC-NER (Saccharomyces cerevisiae)
        
        TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Saccharomyces cerevisiae)
        
        TFIIH [nucleoplasm] (Saccharomyces cerevisiae)
        
        TFB1 [nucleoplasm] (Saccharomyces cerevisiae)
        
        TC-NER post-incision complex:dsDNA with transcription bubble [nucleoplasm] (Saccharomyces cerevisiae)
        
        TFIIH [nucleoplasm] (Saccharomyces cerevisiae)
        
        TFB1 [nucleoplasm] (Saccharomyces cerevisiae)
      - Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Saccharomyces cerevisiae)
        
        TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Saccharomyces cerevisiae)
        
        TFIIH [nucleoplasm] (Saccharomyces cerevisiae)
        
        TFB1 [nucleoplasm] (Saccharomyces cerevisiae)
        
        TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Saccharomyces cerevisiae)
        
        TFIIH [nucleoplasm] (Saccharomyces cerevisiae)
        
        TFB1 [nucleoplasm] (Saccharomyces cerevisiae)

External Reference Information

External Reference

UniProt:P32776

Gene Names

TFB1

Reference Genes

BioGPS Gene:851906 TFB1

ENSEMBL:YDR311W

KEGG Gene (Saccharomyces cerevisiae (strain RM11-1a)):YDR311W TFB1

Monarch:851906 TFB1

NCBI Gene:851906 TFB1

SGD:YDR311W

Reference Transcript

RefSeq:NM_001180619.3 TFB1

Other Identifiers

1777572_at

6141_at

851906

GO:0000112

GO:0000439

GO:0003674

GO:0005515

GO:0005575

GO:0005634

GO:0005675

GO:0005737

GO:0005829

GO:0006281

GO:0006289

GO:0006351

GO:0006352

GO:0006360

GO:0006366

GO:0006367

GO:0006468

GO:0006974

GO:0008150

GO:0008289

GO:0010314

GO:0032266

GO:0070816

Participates

as a component of

TFIIH [nucleoplasm] (Saccharomyces cerevisiae)

Inferred From

GTF2H1 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_010597.3

PRO

P32776

PDB

5OQJ, 7K04, 7O72, 7ZSA, 7O73, 2K2U, 7O75, 7ML3, 7ZSB, 7ML4, 5URN, 7ZS9, 7O4J, 2GS0, 2N23, 7O4K, 7O4L, 7ML1, 7K01, 7ML2, 7O4I, 2L2I, 7ML0, 1Y5O, 2MKR, 7M2U, 2N0Y, 6GYM, 2M14, 2LOX, 5OQM

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.719	7

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