TRM5 methylates guanosine yielding 1-methylguanosine at nucleotide 37 of tRNA(Phe)

Stable Identifier
R-SCE-6783396
Type
Reaction [transition]
Species
Saccharomyces cerevisiae
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
TRM5 methylates guanosine yielding 1-methylguanosine at nucleotide 37 of tRNA(Phe)
TRM5 transfers a methyl group from S-adenosylmethionine to the 1 position of guanosine-37 of tRNA(Phe) (Björk et al. 2001, Jackman et al. 2008, Ohira and Suzuki 2011)
Literature References
PubMed ID Title Journal Year
21670254 Retrograde nuclear import of tRNA precursors is required for modified base biogenesis in yeast

Suzuki, T, Ohira, T

Proc. Natl. Acad. Sci. U.S.A. 2011
11226173 A primordial tRNA modification required for the evolution of life?

Nilsson, K, Byström, AS, Johansson, MJ, Björk, GR, Jacobsson, K, Persson, OP

EMBO J. 2001
18982304 The use of Saccharomyces cerevisiae proteomic libraries to identify RNA-modifying proteins

Phizicky, EM, Grayhack, EJ, Jackman, JE

Methods Mol. Biol. 2008
Participants
Input
Output
Event Information
Go Biological Process
tRNA modification (0006400)
Catalyst Activity

tRNA (guanine(37)-N(1))-methyltransferase activity of TRM5 [nucleoplasm]

Physical Entity
TRM5 [nucleoplasm] (Saccharomyces cerevisiae)
Activity
tRNA (guanine(37)-N(1))-methyltransferase activity (GO:0052906)
Orthologous Events
TRMT5 methylates guanosine yielding 1-methylguanosine at nucleotide 37 of tRNA(Phe) (Homo sapiens)
Authored
May, B  (2015-06-13)
Reviewed
Motorin, Y  (2015-08-25)
Jarrous, N  (2015-10-24)
Created
May, B  (2015-06-15)
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