TYW1:FMN:4Fe-4S transforms 1-methylguanosine yielding yW-187 at nucleotide 37 of tRNA(Phe)

Stable Identifier
R-SCE-6783428
Type
Reaction [transition]
Species
Saccharomyces cerevisiae
Compartment
General
SVG |   | PPTX  | SBGN
TYW1:FMN:4Fe-4S transforms 1-methylguanosine yielding yW-187 at nucleotide 37 of tRNA(Phe)

TYW1 in a complex with FMN and an iron-sulfur cluster transfers 2 carbon atoms from pyruvate to 1-methylguanosine-37 of tRNA(Phe), yielding yW-187 (4-demethylwyosine) at nucleotide 37 (Noma et al. 2006, Noma and Suzuki 2006).

Literature References
PubMed ID Title Journal Year
16642040 Biosynthesis of wybutosine, a hyper-modified nucleoside in eukaryotic phenylalanine tRNA

Noma, A, Kirino, Y, Ikeuchi, Y, Suzuki, T

EMBO J. 2006
17150819 Ribonucleome analysis identified enzyme genes responsible for wybutosine synthesis

Noma, A, Suzuki, T

Nucleic Acids Symp Ser (Oxf) 2006
Participants
Event Information
Go Biological Process
Catalyst Activity
Catalyst Activity
Title
lyase activity of TYW1:FMN:4Fe-4S [cytoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created