KEOPS (EKC) complex threonylcarbamoylates adenosine-37 of tRNAs

Stable Identifier
R-SCE-6784469
Type
Reaction [transition]
Species
Saccharomyces cerevisiae
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
KEOPS (EKC) complex threonylcarbamoylates adenosine-37 of tRNAs
The highly conserved EKC complex (BUD32:CGI121:KAE1:PCC1) transfers a threonylcarbamoyl group from L-threonylcarbamoyladenylate to adenosine-37 of tRNAs, yielding threonylcarbamoyladenosine-37 (Srinivasan et al. 2011, Perrochia et al. 2013).
Literature References
PubMed ID Title Journal Year
23945934 Functional assignment of KEOPS/EKC complex subunits in the biosynthesis of the universal t6A tRNA modification

Perrochia, L, Guetta, D, Hecker, A, Forterre, P, Basta, T

Nucleic Acids Res. 2013
21183954 The highly conserved KEOPS/EKC complex is essential for a universal tRNA modification, t6A

Srinivasan, M, Mehta, P, Yu, Y, Prugar, E, Koonin, EV, Karzai, AW, Sternglanz, R

EMBO J. 2011
Participants
Input
Output
Event Information
Go Biological Process
tRNA modification (0006400)
Catalyst Activity

tRNA N(6)-L-threonylcarbamoyladenine synthase activity of KEOPS complex [nucleoplasm]

Physical Entity
KEOPS complex [nucleoplasm] (Saccharomyces cerevisiae)
Activity
tRNA N(6)-L-threonylcarbamoyladenine synthase activity (GO:0061711)
Orthologous Events
KEOPS (EKC) complex threonylcarbamoylates A37 of tRNAs (Homo sapiens)
Authored
May, B  (2015-06-20)
Reviewed
Motorin, Y  (2015-08-25)
Jarrous, N  (2015-10-24)
Created
May, B  (2015-06-20)
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