EKC/KEOPS complex threonylcarbamoylates adenosine-37 of tRNAs

Stable Identifier
R-SCE-6784469
Type
Reaction [transition]
Species
Saccharomyces cerevisiae
Compartment
ReviewStatus
5/5
General
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EKC/KEOPS complex threonylcarbamoylates adenosine-37 of tRNAs
The highly conserved EKC complex (BUD32:CGI121:KAE1:PCC1) transfers a threonylcarbamoyl group from L-threonylcarbamoyladenylate to adenosine-37 of tRNAs, yielding threonylcarbamoyladenosine-37 (Srinivasan et al. 2011, Perrochia et al. 2013).
Literature References
PubMed ID Title Journal Year
23945934 Functional assignment of KEOPS/EKC complex subunits in the biosynthesis of the universal t6A tRNA modification

Basta, T, Perrochia, L, Hecker, A, Forterre, P, Guetta, D

Nucleic Acids Res. 2013
21183954 The highly conserved KEOPS/EKC complex is essential for a universal tRNA modification, t6A

Prugar, E, Koonin, EV, Srinivasan, M, Yu, Y, Sternglanz, R, Mehta, P, Karzai, AW

EMBO J. 2011
Participants
Event Information
Go Biological Process
Catalyst Activity

N(6)-L-threonylcarbamoyladenine synthase activity of EKC complex [nucleoplasm]

Orthologous Events
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