Reactome | PUS7 transforms uridine to pseudouridine at nucleotide 13 of tRNA

PUS7 transforms uridine to pseudouridine at nucleotide 13 of tRNA

Stable Identifier

R-SCE-6786558

Type

Reaction [transition]

Species

Saccharomyces cerevisiae

Compartment

nucleoplasm

ReviewStatus

5/5

General

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PUS7 transforms uridine to pseudouridine at nucleotide 13 of tRNA

PUS7 converts uridine to pseudouridine at nucleotide 13 of cytoplasmic tRNA and at nucleotide 35 of unspliced tRNA(Tyr) (Behm-Ansmant et al. 2003, Urban et al. 2009). PUS7 also synthesizes pseudouridine in U2 snRNA and in pre-tRNA(Tyr). PUS7 is a nuclear protein according to global analysis of protein locations in yeast.

Literature References

PubMed ID	Title	Journal	Year
19114708	RNA sequence and two-dimensional structure features required for efficient substrate modification by the Saccharomyces cerevisiae RNA:{Psi}-synthase Pus7p Urban, A, Motorin, Y, Branlant, C, Behm-Ansmant, I	J. Biol. Chem.	2009
14561887	The Saccharomyces cerevisiae U2 snRNA:pseudouridine-synthase Pus7p is a novel multisite-multisubstrate RNA:Psi-synthase also acting on tRNAs Urban, A, Motorin, Y, Yu, YT, Ma, X, Branlant, C, Behm-Ansmant, I	RNA	2003

Participants

Input

tRNA containing U-13, pre-tRNA(Tyr) containing U-35 [nucleoplasm] (Saccharomyces cerevisiae)

Output

tRNA containing pseudoU-13, pre-tRNA(Tyr) containing pseudoU-35 [nucleoplasm] (Saccharomyces cerevisiae)

Event Information

Go Biological Process

tRNA modification (0006400)

Catalyst Activity

pseudouridine synthase activity of PUS7 [nucleoplasm]

Physical Entity

PUS7 [nucleoplasm] (Saccharomyces cerevisiae)

Activity

pseudouridine synthase activity (GO:0009982)

Orthologous Events

PUS7 transforms uridine to pseudouridine in tRNAs (Homo sapiens)

Authored

May, B (2015-06-30)

Reviewed

Motorin, Y (2015-08-25)

Jarrous, N (2015-10-24)

Created

May, B (2015-07-09)

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