MSS1 and MTO1 transform uridine-34 to 5-carboxymethylaminomethyluridine-34 in tRNA

Stable Identifier
R-SCE-6787377
Type
Reaction [omitted]
Species
Saccharomyces cerevisiae
Compartment
General
SVG |   | PPTX  | SBGN
MSS1 and MTO1 transform uridine-34 to 5-carboxymethylaminomethyluridine-34 in tRNA

A conserved pathway consisting of at least MSS1 and MTO1 modifies the wobble nucleotide uridine-34 in mitochondrial tRNA (Umeda et al. 2005). A methyl group and a glycine group are conjugated to the 5 position of the uracil ring, yielding 5-carboxymethylaminomethyluridine. The details of the reaction mechanism are unknown. Modification of the wobble nucleotide is required for efficient and accurate translation. Mutations in constituents of the pathway cause mitochondrial dysfunction (Umeda et al. 2005, Wang et al. 2010).

Participants
Event Information
Go Biological Process
Catalyst Activity
Catalyst Activity
Title
transferase activity of MSS1 [mitochondrial matrix]
Physical Entity
Activity
Title
transferase activity of MTO1 [mitochondrial matrix]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created