SLM3 (MTO2, MTU1) transfers a sulfur atom to 5-carboxymethylaminomethyluridine-34 in tRNA

Stable Identifier
R-SCE-6787385
Type
Reaction [omitted]
Species
Saccharomyces cerevisiae
Compartment
General
SVG |   | PPTX  | SBGN
SLM3 (MTO2, MTU1) transfers a sulfur atom to 5-carboxymethylaminomethyluridine-34 in tRNA

MTU1 transfers a sulfur atom from L-cysteine to the 2 position of 5-carboxymethylaminomethyluridine-34 in tRNAs (Umeda et al. 2005). In Escherichia coli the sulfur is transferred along a relay system of proteins from L-cysteine to uridine. It is unknown if such a relay system also exists in yeast. Mutations in MTU1 act synergistically with mutations in MSS1 (the homolog of GTPBP3) and MTO1 to impair mitochondrial function (Umeda et al. 2005, Wang et al. 2010). Deletion of MTU1 causes mitochondrial failure (Wang et al. 2007) and mutations in MTU1 modify the phenotype produced by mutations in mitochondrial 12S rRNA (Yan et al. 2005).

Participants
Event Information
Go Biological Process
Catalyst Activity
Catalyst Activity
Title
sulfurtransferase activity of SLM3 [mitochondrial matrix]
Physical Entity
Activity
Orthologous Events
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Reviewed
Created