Reactome | TRM44 2'-O-methylates uridine-44 in tRNA(Ser)

TRM44 2'-O-methylates uridine-44 in tRNA(Ser)

Stable Identifier

R-SCE-6788673

Type

Reaction [transition]

Species

Saccharomyces cerevisiae

Compartment

cytosol

ReviewStatus

5/5

General

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TRM44 2'-O-methylates uridine-44 in tRNA(Ser)

TRM44 methylates the 2' hydroxyl group of uridine-44 in tRNA(Ser) (Kotelawala et al. 2008). The resulting 2'-O-methyluridine-44 together with N(4)-acetylcytidine appears to be required to maintain abundance of tRNA(Ser).

Literature References

PubMed ID	Title	Journal	Year
18025252	Identification of yeast tRNA Um(44) 2'-O-methyltransferase (Trm44) and demonstration of a Trm44 role in sustaining levels of specific tRNA(Ser) species Kotelawala, L, Grayhack, EJ, Phizicky, EM	RNA	2008

Participants

Input

Output

Event Information

Go Biological Process

tRNA methylation (0030488)

Catalyst Activity

tRNA(Ser) (uridine(44)-2'-O-)-methyltransferase activity of TRM44 [cytosol]

Physical Entity

TRM44 [cytosol] (Saccharomyces cerevisiae)

Activity

tRNA(Ser) (uridine(44)-2'-O-)-methyltransferase activity (GO:0141101)

Orthologous Events

TRMT44 2'-O-methylates uridine-44 in tRNA(Ser) (Homo sapiens)

Authored

May, B (2015-07-23)

Reviewed

Motorin, Y (2015-08-25)

Jarrous, N (2015-10-24)

Created

May, B (2015-07-24)

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