Reactome: A Curated Pathway Database

EMG1 of the SSU processome methylates pseudouridine-1191 of 18S rRNA yielding N(1)-methylpseudouridine-1191

Stable Identifier
R-SCE-6790936
Type
Reaction
Species
Saccharomyces cerevisiae
Compartment
Summation

EMG1 (NEP1) methylates a pseudouridine residue in precursor rRNA (pre-rRNA) to yield N(1)-methylpseudouridine (Meyer et al. 2011). Following further modification and nucleolytic processing, the N(1)-methylpseudouridine residue becomes N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine-1191 of the 18S rRNA. EMG1 recognizes the nucleotide to be methylated by base-specific interactions with RNA (Thomas et al. 2011). EMG1 is a component of the small subunit processome (SSU processome) a large complex of proteins that binds the 5' region of pre-rRNA, processes and modifies the 18S rRNA, and assists the assembly of the small ribosomal subunit (Bernstein et al. 2004).

Literature References
Participants
This entity is regulated by:
Title Physical Entity Activity
rRNA (pseudouridine) methyltransferase activity of SSU Processome [nucleoplasm] SSU Processome [nucleoplasm] rRNA (pseudouridine) methyltransferase activity (0070037)
Orthologous Events