EMG1 of the SSU processome methylates pseudouridine-1191 of 18S rRNA yielding N(1)-methylpseudouridine-1191

Stable Identifier
R-SCE-6790936
Type
Reaction
Species
Saccharomyces cerevisiae
Compartment
Summation

EMG1 (NEP1) methylates a pseudouridine residue in precursor rRNA (pre-rRNA) to yield N(1)-methylpseudouridine (Meyer et al. 2011). Following further modification and nucleolytic processing, the N(1)-methylpseudouridine residue becomes N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine-1191 of the 18S rRNA. EMG1 recognizes the nucleotide to be methylated by base-specific interactions with RNA (Thomas et al. 2011). EMG1 is a component of the small subunit processome (SSU processome) a large complex of proteins that binds the 5' region of pre-rRNA, processes and modifies the 18S rRNA, and assists the assembly of the small ribosomal subunit (Bernstein et al. 2004).

Participants
Event Information
Go Biological Process
Catalyst Activity
Catalyst Activity
Title
rRNA (pseudouridine) methyltransferase activity of SSU Processome [nucleoplasm]
Physical Entity
Activity
Orthologous Events