NOP2 methylates cytosine-2870 of 25S rRNA yielding 5-methylcytosine-2870

Stable Identifier
R-SCE-6790942
Type
Reaction [transition]
Species
Saccharomyces cerevisiae
Compartment
ReviewStatus
5/5
General
SVG |   | PPTX  | SBGN
NOP2 methylates cytosine-2870 of 25S rRNA yielding 5-methylcytosine-2870
NOP2 methylates the carbon at the 5th position of the cytosine ring at cytidine-2870 in 25S rRNA (Sharma et al. 2013, Bourgeois et al. 2015). NOP2 also has a role in rRNA processing that is independent of its methylase activity (Bourgeois et al. 2015).
Literature References
PubMed ID Title Journal Year
23913415 Yeast Nop2 and Rcm1 methylate C2870 and C2278 of the 25S rRNA, respectively

K├Âtter, P, Sharma, S, Watzinger, P, Entian, KD, Yang, J

Nucleic Acids Res. 2013
8972218 Nop2p is required for pre-rRNA processing and 60S ribosome subunit synthesis in yeast

Hong, B, Brockenbrough, JS, Aris, JP, Wu, P

Mol. Cell. Biol. 1997
26196125 Eukaryotic rRNA Modification by Yeast 5-Methylcytosine-Methyltransferases and Human Proliferation-Associated Antigen p120

Schaefer, M, Ney, M, Kellner, S, Motorin, Y, Aigueperse, C, Bourgeois, G, Gaspar, I, Helm, M

PLoS ONE 2015
Participants
Event Information
Go Biological Process
Catalyst Activity

rRNA (cytosine-C5-)-methyltransferase activity of NOP2 [nucleoplasm]

Orthologous Events
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