Reactome | HSPA6 [secretory granule lumen]

HSPA6 [secretory granule lumen]

Stable Identifier

R-SCE-6801472-4

Type

Protein [EntityWithAccessionedSequence]

Species

Saccharomyces cerevisiae

Compartment

secretory granule lumen

Synonyms

P11484

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P11484

Reference Genes

BioGPS Gene:851369

ENSEMBL:YDL229W

KEGG:sce:YDL229W

Monarch:851369

NCBI Gene:851369

SGD:YDL229W

UCSC:P11484

Reference Transcript

RefSeq:NM_001180289.1

Other Identifiers

1770173_at

1770884_s_at

851369

9094_s_at

GO:0000054

GO:0000166

GO:0002181

GO:0003674

GO:0005515

GO:0005516

GO:0005524

GO:0005575

GO:0005634

GO:0005737

GO:0005829

GO:0005844

GO:0005886

GO:0006364

GO:0006412

GO:0006414

GO:0006415

GO:0006450

GO:0006452

GO:0006457

GO:0008150

GO:0016020

GO:0016787

GO:0016887

GO:0031072

GO:0042026

GO:0042149

GO:0042594

GO:0043167

GO:0044183

GO:0051082

GO:0051083

GO:0051085

GO:0051169

GO:0140657

GO:0140662

Participates

as a member of

Homologues of HSPA6 [secretory granule lumen] (Saccharomyces cerevisiae)

Other forms of this molecule

HSPA1L [cytosol]

HSPA2 [cytosol]

HSPA1A [cytosol]

HSPA6 [extracellular region]

HSPA6 [ficolin-1-rich granule lumen]

HSPA1A [ficolin-1-rich granule lumen]

HSPA1A [extracellular region]

HSPA1A [nucleoplasm]

HSPA2 [nucleoplasm]

HSPA1L [nucleoplasm]

HSPA14 [nucleoplasm]

HSPA6 [nucleoplasm]

HSPA13 [nucleoplasm]

HSPA14 [cytosol]

HSPA13 [cytosol]

HSPA6 [cytosol]

Inferred From

HSPA6 [secretory granule lumen] (Homo sapiens)

Cross References

RefSeq

NP_010052.1

ENSEMBL

YDL229W_mRNA

IntEnz

3.6.4.10

PRO

P11484

PDB

3GL1

Interactors (68)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P32589	5	SSE1 [nucleoplasm] (R-SCE-5252053) SSE1 [nucleoplasm] (R-SCE-5251998) SSE1 [cytosol] (R-SCE-5251943) SSE1 [cytosol] (R-SCE-5251946) SSE1 [cytosol] (R-SCE-3299412)	0.744	5
UniProt:P30822	2	CRM1 [cytosol] (R-SCE-165539) CRM1 [nucleoplasm] (R-SCE-165529)	0.643	3
UniProt:P32598	1	PPP1CC [cytosol] (R-SCE-163443)	0.643	4
UniProt:P07260	1	CDC33 [cytosol] (R-SCE-72578)	0.643	3
UniProt:P02829	11	HSP90AA1 [cytosol] (R-SCE-192864) HSP90AB1 [nucleoplasm] (R-SCE-5082399) HSP90AA1 [nucleoplasm] (R-SCE-5082401) HSP90AB1 [cytosol] (R-SCE-419617) HSP90AA1 [plasma membrane] (R-SCE-534996) HSP90AA1 [secretory granule lumen] (R-SCE-6801515) HSP90AB1 [secretory granule lumen] (R-SCE-6801477) HSP90AA1 [extracellular region] (R-SCE-3221946) HSP90AB1 [extracellular region] (R-SCE-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-SCE-6801491) HSP90AA1 [ficolin-1-rich granule lumen] (R-SCE-6801470)	0.564	3
UniProt:P29469 MCM2	2	MCM2 [nucleoplasm] (R-SCE-68557) yMcm2 [nucleoplasm] (R-SCE-169497)	0.564	2
UniProt:P29496 MCM5	2	MCM5 [nucleoplasm] (R-SCE-68551) yMcm5 [nucleoplasm] (R-SCE-169511)	0.527	3
UniProt:P38123	1	SWD3 [nucleoplasm] (R-SCE-1629838)	0.527	2
UniProt:Q06682	2	UBX5 [cytosol] (R-SCE-9755305) UBX5 [cytosol] (R-SCE-8956071)	0.527	2
UniProt:Q12377	4	RPN6 [cytosol] (R-SCE-68790) RPN6 [secretory granule lumen] (R-SCE-6800943) RPN6 [extracellular region] (R-SCE-6806441) RPN6 [ficolin-1-rich granule lumen] (R-SCE-6800436)	0.527	2
UniProt:P43558	1	YOD1 [cytosol] (R-SCE-6781909)	0.527	2
UniProt:Q03529	1	FA2H [endoplasmic reticulum membrane] (R-SCE-5693771)	0.527	2
UniProt:P32447	1	ASF1 [nucleoplasm] (R-SCE-417169)	0.527	3
UniProt:P32775	1	GLC3 [cytosol] (R-SCE-71576)	0.527	3
UniProt:Q08647 PUS7	1	PUS7 [nucleoplasm] (R-SCE-6786522)	0.527	2
UniProt:P38205 NCL1	1	NCL1 [nucleoplasm] (R-SCE-6790210)	0.527	2
UniProt:P25357	2	SNT1 [nucleoplasm] (R-SCE-442469) SNT1 [nucleoplasm] (R-SCE-442501)	0.527	2
UniProt:Q04062	4	RPN9 [cytosol] (R-SCE-68794) RPN9 [secretory granule lumen] (R-SCE-6800983) RPN9 [extracellular region] (R-SCE-6806469) RPN9 [ficolin-1-rich granule lumen] (R-SCE-6800413)	0.527	2
UniProt:P32567	9	phospho-PAH1 [nucleoplasm] (R-SCE-4419936) phospho-PAH1 [nucleoplasm] (R-SCE-4419933) phospho-PAH1 [nucleoplasm] (R-SCE-4419935) PAH1 [nuclear envelope] (R-SCE-4419927) PAH1 [nuclear envelope] (R-SCE-4419928) PAH1 [nuclear envelope] (R-SCE-4419926) PAH1 [endoplasmic reticulum membrane] (R-SCE-549157) PAH1 [endoplasmic reticulum membrane] (R-SCE-549160) PAH1 [endoplasmic reticulum membrane] (R-SCE-549165)	0.527	2
UniProt:P03965	1	CPS1 [mitochondrial matrix] (R-SCE-70544)	0.527	2
UniProt:P10823	5	GNAT1 [cytosol] (R-SCE-2565915) N-(C14:0)-GNAT1 [photoreceptor disc membrane] (R-SCE-2534062) GNAT1 (Met removed) [cytosol] (R-SCE-2534043) GNAZ [plasma membrane] (R-SCE-167416) GNAI3 [plasma membrane] (R-SCE-55365)	0.527	2
UniProt:P39984	1	HAT2 [nucleoplasm] (R-SCE-212227)	0.527	2
UniProt:P54839	2	ERG13 [mitochondrial matrix] (R-SCE-56573) ERG13 [cytosol] (R-SCE-191329)	0.527	2
UniProt:P25847	1	MSH2 [nucleoplasm] (R-SCE-5357525)	0.527	2
UniProt:P10592	20	SSA2 [cytosol] (R-SCE-264476) SSA2 [nucleoplasm] (R-SCE-5082380) SSA2 [cytosol] (R-SCE-3371410-3) SSA2 [cytosol] (R-SCE-3371408-3) SSA2 [cytosol] (R-SCE-6792602-3) SSA2 [secretory granule lumen] (R-SCE-6801530) SSA2 [secretory granule lumen] (R-SCE-6801472-3) SSA2 [extracellular region] (R-SCE-6806500-3) SSA2 [extracellular region] (R-SCE-6805936) SSA2 [ficolin-1-rich granule lumen] (R-SCE-6801512-3) SSA2 [ficolin-1-rich granule lumen] (R-SCE-6801496-3) SSA2 [ficolin-1-rich granule lumen] (R-SCE-6801494) SSA2 [extracellular region] (R-SCE-6805872-3) SSA2 [nucleoplasm] (R-SCE-6792605-3) SSA2 [nucleoplasm] (R-SCE-912480-3) SSA2 [nucleoplasm] (R-SCE-5082367-3) SSA2 [nucleoplasm] (R-SCE-5252082-3) SSA2 [nucleoplasm] (R-SCE-5252088-3) SSA2 [nucleoplasm] (R-SCE-5252009-3) SSA2 [cytosol] (R-SCE-5251948-3)	0.527	3
UniProt:Q03834	1	MSH6 [nucleoplasm] (R-SCE-5357528)	0.527	3
UniProt:P32496	1	RPN12 [cytosol] (R-SCE-68808)	0.527	2
UniProt:P43565	1	phospho-p-T194,T207,T741-MASTL [nucleoplasm] (R-SCE-2430549)	0.527	3
UniProt:P46995	4	SET2 [nucleoplasm] (R-SCE-1183232) SET2 [nucleoplasm] (R-SCE-1183230) phospho-SET2 [nucleoplasm] (R-SCE-5682984) SET2 [nucleoplasm] (R-SCE-1183215)	0.527	3
UniProt:P48365	2	GYP7 [cytosol] (R-SCE-8854150) GYP7 [autophagosome] (R-SCE-8854607)	0.527	2
UniProt:P40344	8	ATG3 [cytosol] (R-SCE-5671860) CysO264-ATG3-MAP1LC3A [cytosol] (R-SCE-9819371) CysO264-ATG3-GABARAP [cytosol] (R-SCE-9819379) CysO264-ATG3-GABARAPL2 [cytosol] (R-SCE-9819376) CysO264-ATG3-MAP1LC3C [cytosol] (R-SCE-9819377) CysO264-ATG3-GABARAPL1 [cytosol] (R-SCE-9819381) CysO264-ATG3-MAP1LC3B [cytosol] (R-SCE-9819365) CysO264-ATG3-GABARAPL3 [cytosol] (R-SCE-5683569)	0.527	2
UniProt:P29547	1	CAM1 [cytosol] (R-SCE-156925)	0.527	3
UniProt:Q00776	14	APM1 [cytosol] (R-SCE-8863733) APM1 [cytosol] (R-SCE-8863726) APM1 [cytosol] (R-SCE-8862856) APM1 [cytosol] (R-SCE-8862854) APM1 [cytoplasmic vesicle membrane] (R-SCE-351196) APM1 [cytoplasmic vesicle membrane] (R-SCE-351191) APM1 [Golgi membrane] (R-SCE-350813) APM1 [Golgi membrane] (R-SCE-350805) APM1 [trans-Golgi network membrane] (R-SCE-2130404) APM1 [trans-Golgi network membrane] (R-SCE-2130512) APM1 [cytosol] (R-SCE-167700) APM1 [cytosol] (R-SCE-167699) APM1 [plasma membrane] (R-SCE-6806311) APM1 [specific granule membrane] (R-SCE-6799365)	0.527	2
UniProt:P22147 XRN1	2	XRN1 [nucleoplasm] (R-SCE-6791205) XRN1_YEAST [cytosol] (R-SCE-429980)	0.527	2
UniProt:P15303	4	phospho-p-S738,T744 SEC23A [cytosol] (R-SCE-5685740) SEC23A [ER to Golgi transport vesicle membrane] (R-SCE-204024) SEC23A [cytosol] (R-SCE-203972) SEC23A [endoplasmic reticulum membrane] (R-SCE-203976)	0.527	2
UniProt:P23561	1	MAP3K5 [cytosol] (R-SCE-167709)	0.527	2
UniProt:P32525	2	ECM25 [cytosol] (R-SCE-2976577) ECM25 [cytosol] (R-SCE-195193)	0.527	2
UniProt:P38217	1	KAP104 [cytosol] (R-SCE-180743)	0.527	2
UniProt:Q00955	5	Btn-ACACA [cytosol] (R-SCE-2976730) ACACA [cytosol] (R-SCE-1660609) ACACB [mitochondrial outer membrane] (R-SCE-4167505-2) Btn-ACACB [mitochondrial outer membrane] (R-SCE-2993858-2) phospho-Btn-p-S222-ACACB [mitochondrial outer membrane] (R-SCE-8876892-2)	0.527	2
UniProt:P53550	1	DCP2 [cytosol] (R-SCE-429937)	0.527	3
UniProt:P38827	2	SETD1A [nucleoplasm] (R-SCE-3239027) SETD1B [nucleoplasm] (R-SCE-5244714)	0.527	2
UniProt:P33322	1	CBF5 [nucleoplasm] (R-SCE-163102)	0.527	2
UniProt:P54861	2	DNM1L [mitochondrial outer membrane] (R-SCE-351942) DNM1L [cytosol] (R-SCE-351943)	0.527	3
UniProt:P53730	1	ALG12 [endoplasmic reticulum membrane] (R-SCE-449348)	0.527	2
UniProt:P38859 DNA2	2	apo-DNA2 [cytosol] (R-SCE-2564783) DNA2 [nucleoplasm] (R-SCE-68465)	0.527	3
UniProt:P06778	3	RAD52 [nucleoplasm] (R-SCE-4568909) RAD52 [nucleoplasm] (R-SCE-62639) phospho-RAD52 [nucleoplasm] (R-SCE-5686588)	0.527	3
UniProt:P19262	5	KGD2 [mitochondrial matrix] (R-SCE-9858581) KGD2 [mitochondrial matrix] (R-SCE-6792574) KGD2 [mitochondrial matrix] (R-SCE-9853485) KGD2 [mitochondrial matrix] (R-SCE-9853502) KGD2 [mitochondrial matrix] (R-SCE-69993)	0.527	2
UniProt:P02309	14	HHF2 [nucleoplasm] (R-SCE-181902) HHF2 [nucleoplasm] (R-SCE-5651652) HHF2 [nucleoplasm] (R-SCE-5423110) HHF2 [nucleoplasm] (R-SCE-3451124) HHF2 [nucleoplasm] (R-SCE-4568758) HHF2 [nucleoplasm] (R-SCE-4568748) HHF2 [nucleoplasm] (R-SCE-427469) HHF2 [nucleoplasm] (R-SCE-5651656) HHF2 [nucleoplasm] (R-SCE-4754240) HHF2 [nucleoplasm] (R-SCE-4754243) HHF2 [nucleoplasm] (R-SCE-5229015) HHF2 [nucleoplasm] (R-SCE-4568744) HHF2 [nucleoplasm] (R-SCE-212078) HHF2 [nucleoplasm] (R-SCE-4570518)	0.527	3
UniProt:P04819	1	LIG1 [nucleoplasm] (R-SCE-53787)	0.527	2
UniProt:P28817	1	HIBCH [mitochondrial matrix] (R-SCE-70872)	0.527	2
UniProt:Q01477	2	UBP3 [nucleoplasm] (R-SCE-3222218) UBP3 [cytosol] (R-SCE-6782974)	0.527	2
UniProt:P39935	2	phospho-TIF4631 [cytosol] (R-SCE-165762) TIF4631 [cytosol] (R-SCE-72584)	0.527	2
UniProt:P06786	4	monoSUMO1-K-TOP2B [nucleoplasm] (R-SCE-4641297) TOP2B [nucleoplasm] (R-SCE-4641359) monoSUMO1-K-TOP2A [nucleoplasm] (R-SCE-4641367) TOP2A [nucleoplasm] (R-SCE-1362276)	0.527	3
UniProt:P39108	2	PEX7 [peroxisomal membrane] (R-SCE-9033493) PEX7 [cytosol] (R-SCE-9033107)	0.527	2
UniProt:P54784 ORC1	6	ORC1 [nucleoplasm] (R-SCE-68522) yORC1 [nucleoplasm] (R-SCE-9749323) ORC1 [cytosol] (R-SCE-113840) phospho-p-S,T-ORC1 [nucleoplasm] (R-SCE-68943) phospho-PolyUb,p-S,T-ORC1 [nucleoplasm] (R-SCE-9032189) phospho-PolyUb,p-S,T-ORC1 [cytosol] (R-SCE-9032195)	0.527	2
UniProt:P32361 IRE1	3	p-3S,T844-IRE1 [endoplasmic reticulum membrane] (R-SCE-535555) phospho-p-S724-ERN1 [endoplasmic reticulum membrane] (R-SCE-381029) ERN1 [endoplasmic reticulum membrane] (R-SCE-381076)	0.527	2
UniProt:Q99190	2	TSC13 [endoplasmic reticulum membrane] (R-SCE-548663) TSC13 [endoplasmic reticulum membrane] (R-SCE-4127427)	0.527	3
UniProt:P11746	2	phospho-MCM1 [nucleoplasm] (R-SCE-9612518) MCM1 [nucleoplasm] (R-SCE-5666000)	0.527	2
UniProt:Q08920	2	NCBP2 [cytosol] (R-SCE-162458) NCBP2 [nucleoplasm] (R-SCE-51463)	0.527	2
UniProt:Q03957	5	CDK13 [extracellular region] (R-SCE-6806442-2) CDK13 [ficolin-1-rich granule lumen] (R-SCE-6801374-2) CDK13 [nucleoplasm] (R-SCE-6797014-2) CDK12 [nucleoplasm] (R-SCE-6797012-2) CDK9 [nucleoplasm] (R-SCE-51801)	0.527	2
UniProt:Q04958	1	PNPLA6 [endoplasmic reticulum membrane] (R-SCE-1498821)	0.527	2
UniProt:Q06142	4	KAP95 [ficolin-1-rich granule lumen] (R-SCE-6800978) KAP95 [extracellular region] (R-SCE-6806306) KAP95 [specific granule lumen] (R-SCE-6799646) KAP95 [cytosol] (R-SCE-180733)	0.527	3
UniProt:P25454	2	RAD51 [nucleoplasm] (R-SCE-62637) phospho-p-T309-RAD51 [nucleoplasm] (R-SCE-5685231)	0.527	2
UniProt:P24783	4	monoSUMO1-K50-DDX17 [nucleoplasm] (R-SCE-3900104) DDX17 [nucleoplasm] (R-SCE-3900090) monoSUMO1-K53-DDX5 [nucleoplasm] (R-SCE-3900041) DDX5 [nucleoplasm] (R-SCE-3900136)	0.527	3
UniProt:P11075	6	SEC7 [cytosol] (R-SCE-8847839) SEC7 [cytosol] (R-SCE-8847826) SEC7 [cytosol] (R-SCE-8847831) SEC7 [Golgi membrane] (R-SCE-8847837) SEC7 [Golgi membrane] (R-SCE-8847825) SEC7 [Golgi membrane] (R-SCE-8847829)	0.527	3
UniProt:Q03497	10	PAK7 [plasma membrane] (R-SCE-211555-2) PAK5 [cytosol] (R-SCE-428459-2) PAK4 [cytosol] (R-SCE-428461-2) PAK6 [cytosol] (R-SCE-428454-2) phospho-p-S154,T436-PAK3 [cytosol] (R-SCE-5357471-2) PAK3 [cytosol] (R-SCE-428457-2) PAK1 [cytosol] (R-SCE-162629) PAK2 [cytosol] (R-SCE-211604-2) phospho-p-S144,T423-PAK1 [cytosol] (R-SCE-399819) phospho-p-S141,T402-PAK2 [cytosol] (R-SCE-399824-2)	0.527	3
UniProt:Q08972	1	ABCF1 [cytosol] (R-SCE-5216139)	0.527	3
UniProt:P32833 ORC2	2	yORC2 [nucleoplasm] (R-SCE-9749316) ORC2 [nucleoplasm] (R-SCE-68405)	0.527	2